f30b54630224281ca6d8a6daff626c03 236589.pdf 16f8ea4a0908062554adde77faa1a75aa218834c 236589.pdf c128f8c793f43cdd4f65df3c22541259598118579f74d33986c31a6887d91ff0 236589.pdf Title: Towards a more precise therapy in cancer: Exploring epigenetic complexity Subject: Current Opinion in Chemical Biology, 57 (2020) 41-49. doi:10.1016/j.cbpa.2020.04.008 Author: Fernando P. Cossío Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Sep 1 06:28:13 2020 CEST ModDate: Tue Sep 1 06:28:49 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 612.283 x 793.701 pts Page rot: 0 File size: 1094823 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KNCNKE+AdvTTf3919c9c.B Type 1C WinAnsi yes yes no 732 0 KNCNKF+AdvTT82c4f4c4 Type 1C WinAnsi yes yes no 734 0 KNCNKG+AdvTT82c4f4c4+20 Type 1C WinAnsi yes yes no 736 0 KNCNKH+AdvPSED1122 Type 1C MacRoman yes yes no 743 0 KNCNLI+AdvPSED1123 Type 1C WinAnsi yes yes no 741 0 KNCNOI+AdvOTf7c366b2.B Type 1C WinAnsi yes yes no 749 0 KNCNPI+AdvPS44A44B Type 1C WinAnsi yes yes no 520 0 KNCPAD+AdvP4C4E74 Type 1C WinAnsi yes yes no 523 0 KNCPAE+AdvOTd9aa755c.B Type 1C WinAnsi yes yes no 528 0 KNCPNA+AdvTTeeb42827.I Type 1C WinAnsi yes yes no 531 0 KNDAAA+Calibri-Bold CID TrueType Identity-H yes yes yes 538 0 KNDAEA+Calibri CID TrueType Identity-H yes yes yes 539 0 KNDAEB+ArialMT CID TrueType Identity-H yes yes yes 545 0 KNDANP+AdvTTf3919c9c.B+20 Type 1C WinAnsi yes yes no 563 0 KNDANO+AdvP3F4C13 Type 1C WinAnsi yes yes no 559 0 KNDAPP+AdvP4BD310 Type 1C WinAnsi yes yes no 568 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-13 02:33:13 CET RepresentationInformation: 236589.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-11 08:38:18 CET Size: 1094823 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib41' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1068702 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1068702 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 794 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Towards a more precise therapy in cancer: Exploring epigenetic complexity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: From the magic bullet paradigm to multitarget epigenetic inhibitors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Targeting loss-of-function by synthetic lethality epigenetic approaches Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Epigenetic therapy in combination with other drugs to boost immune response or drug sensitivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Conflict of interest statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Towards a more precise therapy in cancer: Exploring epigenetic complexity Author: Fernando P. Cossío Subject: Current Opinion in Chemical Biology, 57 (2020) 41-49. doi:10.1016/j.cbpa.2020.04.008 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Sep 01 06:58:13 CEST 2020 ModDate: Tue Sep 01 06:58:49 CEST 2020 ID: 0x3dcf6fd2dc669495712c494efbf323f5, 0x9d7706cea8ba464d9394cdbc21c381fc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 102 ImageHeight: 102 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 566 ImageHeight: 137 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 190 ImageHeight: 209 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1586 ImageHeight: 1461 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1528 ImageHeight: 1230 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 299 ImageHeight: 256 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 98 ImageHeight: 123 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 294 ImageHeight: 4 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 97 ImageHeight: 121 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 300 ImageHeight: 256 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 233 ImageHeight: 224 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 142 ImageHeight: 149 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 227 ImageHeight: 218 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 294 ImageHeight: 249 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 155 ImageHeight: 151 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 142 ImageHeight: 149 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 295 ImageHeight: 4 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 295 ImageHeight: 249 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 159 ImageHeight: 156 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 295 ImageHeight: 249 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 300 ImageHeight: 256 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 142 ImageHeight: 149 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 287 ImageHeight: 4 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 293 ImageHeight: 250 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 138 ImageHeight: 146 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 287 ImageHeight: 243 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: KNDAEB+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: KNDAAA+Calibri-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: KNDAEA+Calibri Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: KNCNKG+AdvTT82c4f4c4+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: KNCNKG+AdvTT82c4f4c4+20 Flags: Nonsymbolic FontBBox: 0, -156, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCNLI+AdvPSED1123 FontSubset: true FirstChar: 97 LastChar: 120 FontDescriptor: FontName: KNCNLI+AdvPSED1123 Flags: Nonsymbolic FontBBox: -187, -229, 1145, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCNKH+AdvPSED1122 FontSubset: true FirstChar: 37 LastChar: 223 FontDescriptor: FontName: KNCNKH+AdvPSED1122 Flags: Serif, Nonsymbolic FontBBox: -156, -229, 1093, 760 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KNCNPI+AdvPS44A44B FontSubset: true FirstChar: 100 LastChar: 101 FontDescriptor: FontName: KNCNPI+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCPAD+AdvP4C4E74 FontSubset: true FirstChar: 254 LastChar: 254 FontDescriptor: FontName: KNCPAD+AdvP4C4E74 Flags: Nonsymbolic FontBBox: -20, -958, 1114, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCNOI+AdvOTf7c366b2.B FontSubset: true FirstChar: 68 LastChar: 116 FontDescriptor: FontName: KNCNOI+AdvOTf7c366b2.B Flags: Nonsymbolic FontBBox: -62, -302, 895, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNDANO+AdvP3F4C13 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: KNDANO+AdvP3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCPAE+AdvOTd9aa755c.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: KNCPAE+AdvOTd9aa755c.B Flags: Nonsymbolic FontBBox: -93, -270, 1166, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCPNA+AdvTTeeb42827.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: KNCPNA+AdvTTeeb42827.I Flags: Nonsymbolic FontBBox: -52, -218, 1093, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNDANP+AdvTTf3919c9c.B+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: KNDANP+AdvTTf3919c9c.B+20 Flags: Nonsymbolic FontBBox: 0, -166, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNDAPP+AdvP4BD310 FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: KNDAPP+AdvP4BD310 Flags: Nonsymbolic FontBBox: 0, -208, 989, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCNKE+AdvTTf3919c9c.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: KNCNKE+AdvTTf3919c9c.B Flags: Nonsymbolic FontBBox: -41, -218, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KNCNKF+AdvTT82c4f4c4 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: KNCNKF+AdvTT82c4f4c4 Flags: Nonsymbolic FontBBox: -10, -218, 947, 927 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: KNDAEA+Calibri CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KNDAEA+Calibri Flags: Symbolic FontBBox: -503, -313, 1240, 1026 FontFile2: true Font: BaseFont: KNDAEB+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KNDAEB+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true Font: BaseFont: KNDAAA+Calibri-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KNDAAA+Calibri-Bold Flags: Symbolic FontBBox: -519, -349, 1263, 1039 FontFile2: true XMP: application/pdf doi:10.1016/j.cbpa.2020.04.008 Towards a more precise therapy in cancer: Exploring epigenetic complexity Fernando P. Cossío Manel Esteller María Berdasco Epidrugs DNA methylation Histone modifications Dual inhibitors Multitargeting Synthetic lethality Chemoresistance Immunotherapy Current Opinion in Chemical Biology, 57 (2020) 41-49. doi:10.1016/j.cbpa.2020.04.008 Elsevier Ltd journal Current Opinion in Chemical Biology © 2020 The Author(s). Published by Elsevier Ltd. 1367-5931 57 August 2020 Chemical Genetics and Epigenetics 㗏 Molecular Imaging 41-49 41 49 10.1016/j.cbpa.2020.04.008 https://doi.org/10.1016/j.cbpa.2020.04.008 2010-04-23 true 10.1016/j.cbpa.2020.04.008 elsevier.com sciencedirect.com VoR 10.1016/j.cbpa.2020.04.008 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2020-09-01T09:58:13+05:30 2020-09-01T09:58:49+05:30 2020-09-01T09:58:49+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:a1ff8e66-f44c-4bf2-bf3d-8af51bc821e3 uuid:8eb88daa-2a9f-4ad8-93a2-a58e213f9e59 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 41 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 197, 632, 203, 647 Destination: 676 Annotation: Subtype: Link Rect: 206, 632, 213, 647 Destination: 676 Annotation: Subtype: Link Rect: 321, 632, 327, 647 Destination: 676 Annotation: Subtype: Link Rect: 330, 632, 337, 647 Destination: 676 Annotation: Subtype: Link Rect: 340, 632, 346, 647 Destination: 676 Annotation: Subtype: Link Rect: 350, 632, 356, 647 Destination: 676 Annotation: Subtype: Link Rect: 170, 614, 177, 629 Destination: 676 Annotation: Subtype: Link Rect: 180, 614, 186, 629 Destination: 676 Annotation: Subtype: Link Rect: 202, 139, 271, 146 Annotation: Subtype: Link Rect: 60, 129, 112, 137 Annotation: Subtype: Link Rect: 432, 574, 450, 582 Annotation: Subtype: Link Rect: 480, 574, 507, 582 Annotation: Subtype: Link Rect: 320, 547, 465, 555 Annotation: Subtype: Link Rect: 475, 524, 553, 532 Annotation: Subtype: Link Rect: 320, 515, 384, 522 Annotation: Subtype: Link Rect: 538, 342, 543, 352 Destination: 139 Annotation: Subtype: Link Rect: 546, 342, 551, 352 Destination: 139 Annotation: Subtype: Link Rect: 534, 656, 558, 680 Annotation: Subtype: Link Rect: 253, 760, 350, 769 Annotation: Subtype: Link Rect: 60, 31, 138, 39 Page: Label: 42 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 126, 666, 131, 676 Destination: 139 Annotation: Subtype: Link Rect: 315, 536, 320, 546 Destination: 139 Annotation: Subtype: Link Rect: 400, 525, 464, 535 Destination: 1 Annotation: Subtype: Link Rect: 474, 29, 551, 36 Page: Label: 43 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 215, 329, 252, 338 Destination: 1 Annotation: Subtype: Link Rect: 291, 294, 296, 304 Destination: 139 Annotation: Subtype: Link Rect: 280, 168, 285, 178 Destination: 139 Annotation: Subtype: Link Rect: 243, 145, 248, 155 Destination: 139 Annotation: Subtype: Link Rect: 289, 88, 294, 98 Destination: 139 Annotation: Subtype: Link Rect: 462, 317, 497, 327 Destination: 1 Annotation: Subtype: Link Rect: 392, 271, 397, 281 Destination: 139 Annotation: Subtype: Link Rect: 322, 180, 327, 190 Destination: 139 Annotation: Subtype: Link Rect: 546, 145, 551, 155 Destination: 139 Annotation: Subtype: Link Rect: 450, 54, 455, 64 Destination: 139 Annotation: Subtype: Link Rect: 60, 29, 138, 36 Page: Label: 44 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 92, 655, 97, 665 Destination: 139 Annotation: Subtype: Link Rect: 195, 620, 205, 630 Destination: null Annotation: Subtype: Link Rect: 197, 574, 207, 584 Destination: null Annotation: Subtype: Link Rect: 159, 540, 194, 550 Destination: 1 Annotation: Subtype: Link Rect: 88, 517, 98, 527 Destination: null Annotation: Subtype: Link Rect: 217, 494, 228, 504 Destination: null Annotation: Subtype: Link Rect: 57, 460, 68, 470 Destination: null Annotation: Subtype: Link Rect: 227, 425, 237, 435 Destination: null Annotation: Subtype: Link Rect: 219, 242, 229, 252 Destination: null Annotation: Subtype: Link Rect: 145, 231, 184, 241 Destination: 12 Annotation: Subtype: Link Rect: 232, 208, 243, 218 Destination: null Annotation: Subtype: Link Rect: 249, 139, 259, 149 Destination: null Annotation: Subtype: Link Rect: 262, 139, 272, 149 Destination: null Annotation: Subtype: Link Rect: 154, 105, 165, 115 Destination: null Annotation: Subtype: Link Rect: 167, 105, 178, 115 Destination: null Annotation: Subtype: Link Rect: 446, 700, 456, 710 Destination: null Annotation: Subtype: Link Rect: 416, 677, 452, 687 Destination: 12 Annotation: Subtype: Link Rect: 534, 666, 544, 676 Destination: null Annotation: Subtype: Link Rect: 327, 655, 338, 665 Destination: null Annotation: Subtype: Link Rect: 379, 655, 389, 665 Destination: null Annotation: Subtype: Link Rect: 476, 643, 486, 653 Destination: null Annotation: Subtype: Link Rect: 482, 551, 492, 561 Destination: null Annotation: Subtype: Link Rect: 411, 529, 421, 539 Destination: null Annotation: Subtype: Link Rect: 534, 506, 544, 516 Destination: null Annotation: Subtype: Link Rect: 355, 460, 365, 470 Destination: null Annotation: Subtype: Link Rect: 315, 349, 325, 359 Destination: null Annotation: Subtype: Link Rect: 344, 120, 381, 130 Destination: 64 Annotation: Subtype: Link Rect: 315, 85, 325, 95 Destination: null Annotation: Subtype: Link Rect: 474, 29, 551, 36 Page: Label: 45 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 286, 249, 296, 259 Destination: null Annotation: Subtype: Link Rect: 65, 238, 100, 248 Destination: 64 Annotation: Subtype: Link Rect: 259, 180, 269, 190 Destination: null Annotation: Subtype: Link Rect: 261, 123, 272, 133 Destination: null Annotation: Subtype: Link Rect: 284, 66, 294, 76 Destination: null Annotation: Subtype: Link Rect: 505, 226, 515, 236 Destination: null Annotation: Subtype: Link Rect: 394, 192, 405, 202 Destination: null Annotation: Subtype: Link Rect: 369, 135, 379, 144 Destination: null Annotation: Subtype: Link Rect: 382, 135, 392, 144 Destination: null Annotation: Subtype: Link Rect: 541, 112, 551, 122 Destination: null Annotation: Subtype: Link Rect: 322, 89, 332, 99 Destination: null Annotation: Subtype: Link Rect: 60, 29, 138, 36 Page: Label: 46 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 276, 620, 287, 630 Destination: null Annotation: Subtype: Link Rect: 205, 460, 216, 470 Destination: null Annotation: Subtype: Link Rect: 86, 403, 96, 413 Destination: null Annotation: Subtype: Link Rect: 80, 368, 90, 378 Destination: null Annotation: Subtype: Link Rect: 276, 299, 287, 309 Destination: null Annotation: Subtype: Link Rect: 428, 677, 438, 687 Destination: null Annotation: Subtype: Link Rect: 378, 536, 388, 546 Destination: null Annotation: Subtype: Link Rect: 484, 525, 494, 535 Destination: null Annotation: Subtype: Link Rect: 477, 502, 487, 512 Destination: null Annotation: Subtype: Link Rect: 315, 467, 325, 477 Destination: null Annotation: Subtype: Link Rect: 356, 387, 367, 397 Destination: null Annotation: Subtype: Link Rect: 476, 341, 487, 351 Destination: null Annotation: Subtype: Link Rect: 517, 318, 527, 328 Destination: null Annotation: Subtype: Link Rect: 362, 296, 394, 305 Destination: 109 Annotation: Subtype: Link Rect: 474, 29, 551, 36 Page: Label: 47 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 173, 283, 183, 293 Destination: null Annotation: Subtype: Link Rect: 170, 180, 181, 190 Destination: null Annotation: Subtype: Link Rect: 410, 215, 420, 225 Destination: null Annotation: Subtype: Link Rect: 438, 169, 449, 179 Destination: null Annotation: Subtype: Link Rect: 60, 29, 138, 36 Page: Label: 48 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 226, 280, 275, 288 Annotation: Subtype: Link Rect: 70, 272, 168, 280 Annotation: Subtype: Link Rect: 70, 258, 289, 266 Annotation: Subtype: Link Rect: 70, 250, 281, 258 Annotation: Subtype: Link Rect: 70, 242, 206, 250 Annotation: Subtype: Link Rect: 70, 198, 294, 206 Annotation: Subtype: Link Rect: 70, 190, 282, 198 Annotation: Subtype: Link Rect: 70, 182, 286, 190 Annotation: Subtype: Link Rect: 70, 174, 230, 182 Annotation: Subtype: Link Rect: 70, 145, 294, 152 Annotation: Subtype: Link Rect: 70, 137, 264, 144 Annotation: Subtype: Link Rect: 70, 129, 104, 136 Annotation: Subtype: Link Rect: 70, 115, 283, 122 Annotation: Subtype: Link Rect: 70, 107, 294, 114 Annotation: Subtype: Link Rect: 70, 99, 166, 106 Annotation: Subtype: Link Rect: 70, 85, 282, 92 Annotation: Subtype: Link Rect: 70, 77, 275, 84 Annotation: Subtype: Link Rect: 70, 69, 293, 76 Annotation: Subtype: Link Rect: 70, 61, 179, 68 Annotation: Subtype: Link Rect: 327, 702, 544, 710 Annotation: Subtype: Link Rect: 327, 694, 545, 702 Annotation: Subtype: Link Rect: 327, 687, 545, 694 Annotation: Subtype: Link Rect: 327, 679, 537, 686 Annotation: Subtype: Link Rect: 327, 671, 541, 678 Annotation: Subtype: Link Rect: 327, 663, 447, 670 Annotation: Subtype: Link Rect: 327, 649, 545, 656 Annotation: Subtype: Link Rect: 327, 641, 528, 648 Annotation: Subtype: Link Rect: 327, 633, 540, 640 Annotation: Subtype: Link Rect: 327, 625, 379, 632 Annotation: Subtype: Link Rect: 328, 611, 546, 618 Annotation: Subtype: Link Rect: 328, 603, 551, 610 Annotation: Subtype: Link Rect: 328, 595, 549, 602 Annotation: Subtype: Link Rect: 328, 587, 403, 594 Annotation: Subtype: Link Rect: 328, 557, 551, 565 Annotation: Subtype: Link Rect: 328, 549, 551, 557 Annotation: Subtype: Link Rect: 328, 541, 539, 549 Annotation: Subtype: Link Rect: 328, 533, 508, 541 Annotation: Subtype: Link Rect: 328, 519, 551, 527 Annotation: Subtype: Link Rect: 328, 511, 547, 519 Annotation: Subtype: Link Rect: 328, 503, 549, 511 Annotation: Subtype: Link Rect: 328, 495, 551, 503 Annotation: Subtype: Link Rect: 328, 487, 378, 495 Annotation: Subtype: Link Rect: 328, 473, 543, 481 Annotation: Subtype: Link Rect: 328, 465, 551, 473 Annotation: Subtype: Link Rect: 328, 457, 535, 465 Annotation: Subtype: Link Rect: 328, 449, 544, 457 Annotation: Subtype: Link Rect: 328, 441, 551, 449 Annotation: Subtype: Link Rect: 328, 433, 540, 441 Annotation: Subtype: Link Rect: 328, 420, 509, 427 Annotation: Subtype: Link Rect: 328, 412, 551, 419 Annotation: Subtype: Link Rect: 328, 404, 533, 411 Annotation: Subtype: Link Rect: 328, 396, 525, 403 Annotation: Subtype: Link Rect: 328, 388, 368, 395 Annotation: Subtype: Link Rect: 328, 374, 530, 381 Annotation: Subtype: Link Rect: 328, 366, 543, 373 Annotation: Subtype: Link Rect: 328, 358, 537, 365 Annotation: Subtype: Link Rect: 328, 350, 544, 357 Annotation: Subtype: Link Rect: 328, 342, 368, 349 Annotation: Subtype: Link Rect: 328, 328, 551, 335 Annotation: Subtype: Link Rect: 328, 320, 551, 327 Annotation: Subtype: Link Rect: 328, 312, 371, 319 Annotation: Subtype: Link Rect: 328, 298, 551, 305 Annotation: Subtype: Link Rect: 328, 290, 551, 297 Annotation: Subtype: Link Rect: 328, 282, 551, 290 Annotation: Subtype: Link Rect: 328, 274, 548, 282 Annotation: Subtype: Link Rect: 328, 266, 514, 274 Annotation: Subtype: Link Rect: 328, 236, 540, 244 Annotation: Subtype: Link Rect: 328, 228, 540, 236 Annotation: Subtype: Link Rect: 328, 220, 549, 228 Annotation: Subtype: Link Rect: 328, 212, 403, 220 Annotation: Subtype: Link Rect: 328, 198, 540, 206 Annotation: Subtype: Link Rect: 328, 190, 551, 198 Annotation: Subtype: Link Rect: 328, 182, 546, 190 Annotation: Subtype: Link Rect: 328, 174, 537, 182 Annotation: Subtype: Link Rect: 328, 166, 359, 174 Annotation: Subtype: Link Rect: 328, 153, 551, 160 Annotation: Subtype: Link Rect: 328, 145, 551, 152 Annotation: Subtype: Link Rect: 328, 137, 538, 144 Annotation: Subtype: Link Rect: 328, 129, 400, 136 Annotation: Subtype: Link Rect: 328, 115, 528, 122 Annotation: Subtype: Link Rect: 328, 107, 551, 114 Annotation: Subtype: Link Rect: 328, 99, 551, 106 Annotation: Subtype: Link Rect: 328, 91, 551, 98 Annotation: Subtype: Link Rect: 328, 83, 332, 90 Annotation: Subtype: Link Rect: 328, 69, 526, 76 Annotation: Subtype: Link Rect: 328, 61, 538, 68 Annotation: Subtype: Link Rect: 474, 29, 551, 36 Page: Label: 49 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 78, 702, 297, 710 Annotation: Subtype: Link Rect: 78, 694, 232, 702 Annotation: Subtype: Link Rect: 78, 665, 301, 672 Annotation: Subtype: Link Rect: 78, 657, 291, 664 Annotation: Subtype: Link Rect: 78, 643, 278, 650 Annotation: Subtype: Link Rect: 78, 635, 301, 642 Annotation: Subtype: Link Rect: 78, 627, 287, 634 Annotation: Subtype: Link Rect: 78, 619, 247, 626 Annotation: Subtype: Link Rect: 78, 605, 287, 612 Annotation: Subtype: Link Rect: 78, 597, 288, 604 Annotation: Subtype: Link Rect: 78, 583, 300, 590 Annotation: Subtype: Link Rect: 78, 575, 298, 582 Annotation: Subtype: Link Rect: 78, 567, 301, 574 Annotation: Subtype: Link Rect: 78, 559, 215, 566 Annotation: Subtype: Link Rect: 78, 545, 285, 553 Annotation: Subtype: Link Rect: 78, 537, 283, 545 Annotation: Subtype: Link Rect: 78, 529, 294, 537 Annotation: Subtype: Link Rect: 78, 521, 301, 529 Annotation: Subtype: Link Rect: 78, 513, 299, 521 Annotation: Subtype: Link Rect: 78, 499, 270, 507 Annotation: Subtype: Link Rect: 78, 491, 301, 499 Annotation: Subtype: Link Rect: 78, 483, 301, 491 Annotation: Subtype: Link Rect: 78, 475, 301, 483 Annotation: Subtype: Link Rect: 78, 467, 221, 475 Annotation: Subtype: Link Rect: 78, 453, 257, 461 Annotation: Subtype: Link Rect: 78, 445, 298, 453 Annotation: Subtype: Link Rect: 78, 437, 301, 445 Annotation: Subtype: Link Rect: 78, 430, 278, 437 Annotation: Subtype: Link Rect: 78, 422, 109, 429 Annotation: Subtype: Link Rect: 78, 408, 273, 415 Annotation: Subtype: Link Rect: 78, 400, 301, 407 Annotation: Subtype: Link Rect: 78, 392, 272, 399 Annotation: Subtype: Link Rect: 78, 384, 301, 391 Annotation: Subtype: Link Rect: 78, 376, 299, 383 Annotation: Subtype: Link Rect: 78, 368, 155, 375 Annotation: Subtype: Link Rect: 78, 338, 282, 345 Annotation: Subtype: Link Rect: 78, 330, 301, 337 Annotation: Subtype: Link Rect: 78, 322, 297, 329 Annotation: Subtype: Link Rect: 78, 314, 272, 321 Annotation: Subtype: Link Rect: 78, 300, 301, 307 Annotation: Subtype: Link Rect: 78, 292, 295, 299 Annotation: Subtype: Link Rect: 78, 284, 277, 292 Annotation: Subtype: Link Rect: 78, 254, 301, 262 Annotation: Subtype: Link Rect: 78, 246, 290, 254 Annotation: Subtype: Link Rect: 78, 238, 301, 246 Annotation: Subtype: Link Rect: 78, 230, 296, 238 Annotation: Subtype: Link Rect: 78, 216, 301, 224 Annotation: Subtype: Link Rect: 78, 208, 288, 216 Annotation: Subtype: Link Rect: 78, 200, 299, 208 Annotation: Subtype: Link Rect: 78, 192, 108, 200 Annotation: Subtype: Link Rect: 335, 702, 557, 710 Annotation: Subtype: Link Rect: 335, 694, 553, 702 Annotation: Subtype: Link Rect: 335, 687, 556, 694 Annotation: Subtype: Link Rect: 335, 679, 555, 686 Annotation: Subtype: Link Rect: 335, 671, 476, 678 Annotation: Subtype: Link Rect: 335, 657, 526, 664 Annotation: Subtype: Link Rect: 335, 649, 551, 656 Annotation: Subtype: Link Rect: 335, 641, 549, 648 Annotation: Subtype: Link Rect: 335, 633, 552, 640 Annotation: Subtype: Link Rect: 335, 625, 558, 632 Annotation: Subtype: Link Rect: 335, 617, 399, 624 Annotation: Subtype: Link Rect: 335, 603, 558, 610 Annotation: Subtype: Link Rect: 335, 595, 557, 602 Annotation: Subtype: Link Rect: 335, 587, 538, 594 Annotation: Subtype: Link Rect: 335, 579, 539, 586 Annotation: Subtype: Link Rect: 335, 571, 434, 578 Annotation: Subtype: Link Rect: 335, 557, 558, 565 Annotation: Subtype: Link Rect: 335, 549, 554, 557 Annotation: Subtype: Link Rect: 335, 541, 544, 549 Annotation: Subtype: Link Rect: 335, 533, 552, 541 Annotation: Subtype: Link Rect: 335, 525, 542, 533 Annotation: Subtype: Link Rect: 335, 517, 430, 525 Annotation: Subtype: Link Rect: 335, 479, 553, 487 Annotation: Subtype: Link Rect: 335, 471, 557, 479 Annotation: Subtype: Link Rect: 335, 463, 366, 471 Annotation: Subtype: Link Rect: 335, 449, 558, 457 Annotation: Subtype: Link Rect: 335, 441, 558, 449 Annotation: Subtype: Link Rect: 335, 433, 553, 441 Annotation: Subtype: Link Rect: 335, 425, 552, 433 Annotation: Subtype: Link Rect: 335, 418, 545, 425 Annotation: Subtype: Link Rect: 335, 410, 431, 417 Annotation: Subtype: Link Rect: 335, 380, 558, 387 Annotation: Subtype: Link Rect: 335, 372, 541, 379 Annotation: Subtype: Link Rect: 335, 364, 558, 371 Annotation: Subtype: Link Rect: 335, 356, 380, 363 Annotation: Subtype: Link Rect: 335, 342, 558, 349 Annotation: Subtype: Link Rect: 335, 334, 499, 341 Annotation: Subtype: Link Rect: 335, 320, 558, 327 Annotation: Subtype: Link Rect: 335, 312, 549, 319 Annotation: Subtype: Link Rect: 335, 304, 556, 311 Annotation: Subtype: Link Rect: 335, 296, 412, 303 Annotation: Subtype: Link Rect: 335, 258, 545, 266 Annotation: Subtype: Link Rect: 335, 250, 546, 258 Annotation: Subtype: Link Rect: 335, 242, 372, 250 Annotation: Subtype: Link Rect: 335, 228, 558, 236 Annotation: Subtype: Link Rect: 335, 220, 557, 228 Annotation: Subtype: Link Rect: 335, 212, 556, 220 Annotation: Subtype: Link Rect: 335, 204, 456, 212 Annotation: Subtype: Link Rect: 60, 29, 138, 36 Checksum: f300716f Type: CRC32 Checksum: f30b54630224281ca6d8a6daff626c03 Type: MD5 Checksum: 16f8ea4a0908062554adde77faa1a75aa218834c Type: SHA-1