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Keywords: spatial genome architecture, 3D chromatin organization, DNA loops, noncoding mutations and epimutations, enhancers, blood cancer, hematopoietic malignancies Author: Llorenc¸ Rovirosa Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Oct 6 03:53:05 2020 CEST ModDate: Tue Oct 6 05:29:27 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 760644 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OHBGOC+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 458 0 OHBGPC+AdvOT01861455.I Type 1C WinAnsi yes yes no 459 0 OHBGPD+AdvPSA18C Type 1C WinAnsi yes yes no 460 0 OHBHAE+AdvOT1deab444.I Type 1C WinAnsi yes yes no 461 0 OHBHAF+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 462 0 OHBHAG+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 463 0 OHBHCG+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 464 0 OHBHEG+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 465 0 OHBHFH+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 478 0 OHBIBD+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 481 0 OHBKDH+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 266 0 OHBILA+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 267 0 OHBKDI+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 269 0 OHBLHB+AdvTT58d178b9+03 Type 1C Custom yes yes yes 275 0 OHBLIC+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 281 0 OHBLID+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 282 0 OHBLMC+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 283 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-16 02:19:27 CET RepresentationInformation: 236596.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-11 08:44:50 CET Size: 760644 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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2020-10-06T11:29:27+08:00 2020-10-06T09:53:05+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2020-10-06T11:29:27+08:00 application/pdf The Genome in a Three-Dimensional Context: Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood Cancer Llorenc¸ Rovirosa Alberto Ramos-Morales Biola M. Javierre Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized. spatial genome architecture 3D chromatin organization DNA loops noncoding mutations and epimutations enhancers blood cancer hematopoietic malignancies uuid:5525f3de-22a9-4fba-87fb-cca3987ad2c0 uuid:a0067840-eb8a-474d-801f-f8fb651553e3 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 613, 539, 634 Annotation: Subtype: Link Rect: 175, 590, 423, 611 Annotation: Subtype: Link Rect: 175, 567, 544, 588 Annotation: Subtype: Link Rect: 175, 544, 475, 565 Annotation: Subtype: Link Rect: 302, 144, 306, 154 Destination: 113 Annotation: Subtype: Link Rect: 391, 133, 395, 142 Destination: 113 Annotation: Subtype: Link Rect: 507, 110, 512, 119 Destination: 113 Annotation: Subtype: Link Rect: 230, 64, 234, 73 Destination: 113 Annotation: Subtype: Link Rect: 239, 64, 243, 73 Destination: 113 Annotation: 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