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Title:          Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope
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     Item: 
      Title: Efficient elimination of primary B-­ALL cells in vitro and in vivo using a novel 4-­1BB-­based CAR targeting a membrane-­dista氀 䌀䐀㈀㈀ꀀ攀瀀椀琀漀瀀攩㸾੥湤潢樊㐰ㄠ〠潢樊㰼⽄⠳㝦攳㌳搭㜵㌳ⴴ㤵㌭㡣㔳ⵤ慣㜰㌵㤳㜵㘮楮摤㩂潯歭慲欠ㄺ㈱㔹
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Background
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Generation of a CD22 single-chain variable fragment (scFv)
         Item: 
          Title: Immunogenicity prediction
         Item: 
          Title: Epitope mapping
         Item: 
          Title: Structural model
         Item: 
          Title: CAR design and vectors, lentiviral production and T cells transduction
         Item: 
          Title: Cell lines
         Item: 
          Title: In vitro cytotoxicity assays and cytokine release determination
         Item: 
          Title: Flow cytometry
         Item: 
          Title: In vivo xenograft models for B-ALL and CAR T cells
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: hCD22.7-CAR T cells efficiently eliminate B-ALL cells in vitro
         Item: 
          Title: The expression level of CD22 impacts the in vitro efficiency of hCD22.7-CAR T cells in killing B-ALL primary cells
         Item: 
          Title: Membrane-distal CD22 epitope-directed CAR T cells efficiently eliminate B-ALL blasts in vivo in clinically relevant patient-de爀椀瘀攀搀 砀攀渀漀最爀愀昀琀猩㸾੥湤潢樊㐰㠠〠潢樊㰼⽁‴ㄷ‰⁒⽃潵湴‱〯䙩牳琠㐱㘠〠刯䱡獴‴ㄸ‰⁒⽎數琠㐱〠〠刯偡牥湴″㤹‰⁒⽐牥瘠㐰㐠〠刯呩瑬攨Materials and methods
       Item: 
        Title: Discussion/Conclusions
       Item: 
        Title: References
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   Type: CRC32
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   Type: MD5
  Checksum: ef9533a064f3818d792c2dbf385ba343e132818e
   Type: SHA-1