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PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Bone marrow MSC from pediatric patients with B-­ALL highly immunosuppress T-­cell responses but do not compromise CD19-­CAR T-관挀攀氀氀ꀀ愀挀琀椀瘀椀琀礩㸾੥湤潢樊㌵㤠〠潢樊㰼⽄⡢㌲〷㡣搭㔳㜵ⴴ㘴㌭㡡㠵ⴸㄸㅥ攸〷〰㘮楮摤㩂潯歭慲欠ㄺ㈱㐶 Children: Item: Title: Abstract Item: Title: Background Item: Title: Materials and methods Children: Item: Title: Reagents, drugs, antibodies and cell lines Item: Title: Human samples Item: Title: Isolation, expansion and characterization of BM-MSC Item: Title: T-cell proliferation and cytokine secretion Item: Title: In vitro chemoresistance of B-ALL cell lines Item: Title: CD19-CAR vector, lentiviral production, T-cell transduction, activation and expansion Item: Title: In vitro CD19-CAR T-cell, cytotoxicity assays and cytokine release determination Item: Title: Induction and treatment of experimental acute severe colitis Item: Title: In vivo CD19-CAR T cell-mediated cytotoxicity assay Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Expansion and characterization of bona fide BM-MSC from pediatric patients with B-ALL Item: Title: B-ALL BM-MSC immunosuppress T-cell response Item: Title: B-ALL BM-MSC exert anti-inflammatory effects in a preclinical model of severe acute colitis Item: Title: BM-MSC do not compromise CD19-CAR T-cell activity in vitro and in vivo Item: Title: Discussion Item: Title: References Info: Title: Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Aug 31 05:35:25 CEST 2020 ModDate: Fri Feb 12 11:34:48 CET 2021 ID: 0x7056a3eca4c29a49a0cea1f717acf887, 0x325bea43d21db2110a00520910000000 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2034 ImageHeight: 3040 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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