352ce4bfe619f3d1692030ee9ab57d61 phar_a2020v13p363.pdf 7b68b4583af2baa3a76a14628b02bcb33a1d1d46 phar_a2020v13p363.pdf 2b2c5497a985d0bb99b283ef76737ab6e14caaf17f1c26cbe168e4b564401946 phar_a2020v13p363.pdf Title: The Effects of Maternal Metformin Treatment on Late Prenatal and Early Postnatal Development of the Offspring Are Modulated by Sex Subject: Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses’ developmental competence. There is no data on the duration of the effect of this treatment from the prenatal up to the postnatal stages. Therefore, the present trial aimed at determining the impact of metformin treatment on the offspring neonatal traits and early postnatal development (i.e., during lactation) using an in vivo swine model. The results support that maternal metformin treatment during pregnancy induces protective changes in body shape and composition of the progeny (i.e., larger head size and body length at birth and higher total viscera weight at weaning). However, there were also major effects of the offspring sex (smaller corpulence in females and lower relative weight of main viscerae in males), which should be considered for further preclinical studies and when even the current clinical application in women affected by PCOS or diabetes is implemented. Keywords: intrauterine growth restriction; metformin; pregnancy; swine model Author: Consolacion Garcia-Contreras, Marta Vazquez-Gomez, José Luis Pesantez-Pacheco, Ana Heras-Molina, Teresa Encinas, Susana Astiz and Antonio Gonzalez-Bulnes Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Nov 4 12:54:08 2020 CET ModDate: Wed Nov 4 12:54:08 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1122600 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JLTEGX+URWPalladioL-Ital Type 1 Custom yes yes no 77 0 GGEBGW+URWPalladioL-Bold Type 1 Custom yes yes no 78 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 79 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 80 0 ZARBPI+URWPalladioL-Roma Type 1 Custom yes yes no 81 0 FATHTC+Rpxr Type 1 Builtin yes yes no 82 0 RSPLPW+VnURWPalladioL Type 1 Custom yes yes no 83 0 VWRBXB+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 88 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 105 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 106 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 107 0 GBLQZB+Rpxi Type 1 Builtin yes yes no 137 0 DNVXPV+Pxsy Type 1 Builtin yes yes no 138 0 PZVLAY+Pxsyc Type 1 Builtin yes yes no 161 0 TGMEOR+Rpcxr Type 1 Builtin yes yes no 250 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-06-03 02:37:26 CEST RepresentationInformation: phar_a2020v13p363.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-06-02 12:02:05 CEST Size: 1122600 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: 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ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰きづぴてはひねどのぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰はのぜ〴ぜ〰ぅちひぬべぜ〴ぜ〰ぐはびぴのちぴちぬぜ〴ぜ〰いづぶづぬはばねづのぴぜ〴ぜ〰ちのつぜ〴ぜ〰あはつべぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰えちのつぬどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰うづちぴふひづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅちひぬべぜ〴ぜ〰ぐはびぴのちぴちぬぜ〴ぜ〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぐどでぬづぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰えちのつぬどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰うづちぴふひづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅちひぬべぜ〴ぜ〰ぐはびぴのちぴちぬぜ〴ぜ〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぐどでぬづぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぁのどねちぬぜ〴ぜ〰えちのつぬどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰うづちぴふひづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅちひぬべぜ〴ぜ〰ぐはびぴのちぴちぬぜ〴ぜ〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぐどでぬづぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰うづちぴふひづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅちひぬべぜ〴ぜ〰ぐはびぴのちぴちぬぜ〴ぜ〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぐどでぬづぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BTFGED+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 178 FontDescriptor: FontName: BTFGED+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZARBPI+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: ZARBPI+URWPalladioL-Roma Flags: Symbolic 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