ae58566c93d2d3df7896b65adb819ef1 241133.pdf db7459caeab39508a9f8a55873673ec07ebcd657 241133.pdf 1f741d3935a7b61e732064d89ca8d73c5a978af4450e2e7bdc6a4a050db96074 241133.pdf Title: SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation Subject: The MAP kinase ERK5 contains an N-terminal kinase domain and a unique C-terminal tail including a nuclear localization signal and a transcriptional activation domain. ERK5 is activated in response to growth factors and stresses and regulates transcription at the nucleus by either phosphorylation or interaction with transcription factors. MEK5-ERK5 pathway plays an important role regulating cancer cell proliferation and survival. Therefore, it is important to define the precise molecular mechanisms implicated in ERK5 nucleo-cytoplasmic shuttling. We previously described that the molecular chaperone Hsp90 stabilizes and anchors ERK5 at the cytosol and that ERK5 nuclear shuttling requires Hsp90 dissociation. Here, we show that MEK5 or overexpression of Cdc37—mechanisms that increase nuclear ERK5—induced ERK5 Small Ubiquitin-related Modifier (SUMO)-2 modification at residues Lys6/Lys22 in cancer cells. Furthermore, mutation of these SUMO sites abolished the ability of ERK5 to translocate to the nucleus and to promote prostatic cancer PC-3 cell proliferation. We also show that overexpression of the SUMO protease SENP2 completely abolished endogenous ERK5 nuclear localization in response to epidermal growth factor (EGF) stimulation. These results allow us to propose a more precise mechanism: in response to MEK5 activation, ERK5 SUMOylation favors the dissociation of Hsp90 from the complex, allowing ERK5 nuclear shuttling and activation of the transcription. Keywords: MAP kinase; ERK5; Bmk1; SUMO; nuclear translocation; transcription; cell proliferation; cancer; Hsp90; Cdc37 Author: Tatiana Erazo, Sergio Espinosa-Gil, Nora Diéguez-Martínez, Néstor Gómez and Jose M Lizcano Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Mar 23 10:13:01 2020 CET ModDate: Mon Mar 23 10:13:01 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2815715 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZUQSDU+URWPalladioL-Ital Type 1 Custom yes yes no 128 0 FZEDDW+URWPalladioL-Bold Type 1 Custom yes yes no 129 0 XWOCXD+VnURWPalladioL-Bold Type 1 Custom yes yes no 130 0 PZWYNL+URWPalladioL-Roma Type 1 Custom yes yes no 131 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes no 132 0 HAKARX+Rpxr Type 1 Builtin 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FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 482 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 483 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 484 0 FNTSBS+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 485 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 546 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 547 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 548 0 FNTSBS+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 549 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 715 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-02 02:45:54 CEST RepresentationInformation: 241133.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-05-25 16:32:15 CEST Size: 2815715 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰きぅか〵ぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃつっ〳〷ぜ〴ぜ〰くぶづひづへばひづびびどはのぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ちぴぜ〴ぜ〰がべび〶ぜ〴ぜ〰ちのつぜ〴ぜ〰がべび〲〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぎふっぬづちひぜ〴ぜ〰ごひちのびぬはっちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ぴはぜ〴ぜ〰きぅか〵〭きづつどちぴづつぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はひぜ〴ぜ〰ぴはぜ〴ぜ〰ぃつっ〳〷ぜ〴ぜ〰くぶづひづへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こさきくぜ〴ぜ〰きはつどてどっちぴどはのぜ〴ぜ〰いはづびぜ〴ぜ〰のはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰かどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰はひぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰きぅか〵ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぃは〭ごひちのびっひどばぴどはのちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぐひはぬどてづひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: きぅか〵ぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃつっ〳〷ぜ〴ぜ〰くぶづひづへばひづびびどはのぜ〴ぜ〰ぉのつふっづぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ちぴぜ〴ぜ〰がべび〶ぜ〴ぜ〰ちのつぜ〴ぜ〰がべび〲〲ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぎふっぬづちひぜ〴ぜ〰ごひちのびぬはっちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ぴはぜ〴ぜ〰きぅか〵〭きづつどちぴづつぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はひぜ〴ぜ〰ぴはぜ〴ぜ〰ぃつっ〳〷ぜ〴ぜ〰くぶづひづへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こさきくぜ〴ぜ〰きはつどてどっちぴどはのぜ〴ぜ〰いはづびぜ〴ぜ〰のはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰かどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰はひぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰きぅか〵ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぃは〭ごひちのびっひどばぴどはのちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぐひはぬどてづひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぎふっぬづちひぜ〴ぜ〰ごひちのびぬはっちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ぴはぜ〴ぜ〰きぅか〵〭きづつどちぴづつぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はひぜ〴ぜ〰ぴはぜ〴ぜ〰ぃつっ〳〷ぜ〴ぜ〰くぶづひづへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰こさきくぜ〴ぜ〰きはつどてどっちぴどはのぜ〴ぜ〰いはづびぜ〴ぜ〰のはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰かどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰はひぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰きぅか〵ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぃは〭ごひちのびっひどばぴどはのちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぐひはぬどてづひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こさきくぜ〴ぜ〰きはつどてどっちぴどはのぜ〴ぜ〰いはづびぜ〴ぜ〰のはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰かどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰はひぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰きぅか〵ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぃは〭ごひちのびっひどばぴどはのちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぐひはぬどてづひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰ぃは〭ごひちのびっひどばぴどはのちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぐひはぬどてづひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こさきくべぬちぴどはのぜ〴ぜ〰ぉびぜ〴ぜ〰ぎづっづびびちひべぜ〴ぜ〰てはひぜ〴ぜ〰えびば〹〰ぜ〴ぜ〰いどびびはっどちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅげか〵〭ぃつっ〳〷ぜ〴ぜ〰ぃはねばぬづへぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰きちぴづひどちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどぢはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰いぎぁぜ〴ぜ〰ぃはのびぴひふっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづ〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰がべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Children: Item: Title: きちぴづひどちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどぢはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰いぎぁぜ〴ぜ〰ぃはのびぴひふっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづ〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰がべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぁのぴどぢはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰いぎぁぜ〴ぜ〰ぃはのびぴひふっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづ〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰がべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: いぎぁぜ〴ぜ〰ぃはのびぴひふっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづ〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰がべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづ〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰がべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぉねねふのはてぬふはひづびっづのっづぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぉねねふのはばひづっどばどぴちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはぢぬはぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぅげか〵ぜ〴ぜ〰こさきくべぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: こふぢっづぬぬふぬちひぜ〴ぜ〰うひちっぴどはのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぅげか〵ぜ〴ぜ〰にどのちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: 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