cafbd1dec6fd4534364a9fbe0412c13a jouclimed_a2020v9n9p2896.pdf 6e5ebe8a24085dad46d9ed82de06790cde4c086d jouclimed_a2020v9n9p2896.pdf b93d0e581156ddb84be985ec6999d314b0cb2427328b3d05766fbb67fd722595 jouclimed_a2020v9n9p2896.pdf Title: Time Trends of Crohn’s Disease in Catalonia from 2011 to 2017. Increasing Use of Biologics Correlates with a Reduced Need for Surgery Subject: Background and Aims: Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn’s disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with outcomes in Catalonia. Materials and Methods: All patients with CD included in the Catalan Health Surveillance System (containing data on a population of more than 7.5 million) from 2011 to 2017 were identified. The exposures to different treatments for inflammatory bowel disease were retrieved from electronic invoicing records. Results: Between 2011 and 2017, the use of salicylates, corticosteroids and immunosuppressive treatment fell from 28.8% to 17.1%, 15.8% to 13.7%, and 32.9% to 29.6%, respectively (p < 0.001). Biological treatment use rose from 15.0% to 18.7% (p < 0.001). Ostomy rates per 1000 patients/year fell from 13.2 in 2011 to 9.8 in 2017 (p = 0.003), and surgical resection rates from 24.1 to 18.0 (p < 0.001). The rate of CD-related hospitalizations per 1000 patients/year also fell, from 92.7 to 72.2 (p < 0.001). Conclusions: Biological drug use rose from 15.0% to 18.7% between 2011 and 2017. During this period, we observed an improvement in the outcomes of CD patients. Keywords: epidemiology; inflammatory bowel disease; Crohn’s disease Author: Eduard Brunet, Emili Vela, Luigi Melcarne, Montserrat Clèries, Caridad Pontes, Laura Patricia Llovet, Pilar García-Iglesias, Marta Gallach, Albert Villòria, Mercedes Vergara and Xavier Calvet Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Sep 8 08:35:08 2020 CEST ModDate: Tue Sep 8 08:35:08 2020 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 807660 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QNPOWO+URWPalladioL-Ital Type 1 Custom yes yes no 73 0 DQZWGY+URWPalladioL-Bold Type 1 Custom yes yes no 74 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 75 0 PQHAUR+VnURWPalladioL-Bold Type 1 Custom yes yes no 76 0 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