998703f764ae5cb899664fd46b345291 244126.pdf d32e8c1ee7e217d5b0561df0769ee31d0fc88b9a 244126.pdf 10eb3641e218b71977801ac666fce7425485a6343da3aef305fa6a43c16c01ac 244126.pdf Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Subject: Science 2020.370:eabd4570 Producer: iText 4.2.0 by 1T3XT CreationDate: Fri Mar 4 09:18:41 2022 CET ModDate: Fri Mar 4 09:19:05 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 593.972 x 756 pts Page rot: 0 File size: 1412861 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- APNNIL+AdvTT2dea7504.B Type 1C WinAnsi yes yes no 618 0 APNNMD+AdvTTd7835f12+22 Type 1C Custom yes yes no 621 0 APNNME+AdvTTd7835f12+25 Type 1C Custom yes yes yes 624 0 APNNMF+AdvTT82e34213.B Type 1C WinAnsi yes yes no 626 0 APNNNG+AdvTTec37d199 Type 1C WinAnsi yes yes no 628 0 APNNNH+AdvTTb278f7d1 Type 1C WinAnsi yes yes no 630 0 APNNOH+AdvTTa15c7c65.I Type 1C WinAnsi yes yes no 632 0 APOBHD+BentonSansCondensed-Bold Type 1C WinAnsi yes yes no 634 0 APOBHE+BentonSansCondensed-Book Type 1C WinAnsi yes yes no 636 0 APOBHF+BentonSansCondensed-Medium Type 1C WinAnsi yes yes no 638 0 APOBHG+BentonSansCondensed-Regular Type 1C WinAnsi yes yes no 640 0 APNNIM+AdvTTdf37bfe4+25 Type 1C Custom yes yes yes 643 0 APNNIN+AdvTTf99636c8.B Type 1C WinAnsi yes yes no 645 0 APNNIO+AdvOT17d99a6a.B Type 1C WinAnsi yes yes no 647 0 APNNIP+AdvTT1ef22648.B Type 1C WinAnsi yes yes no 649 0 APNNJA+AdvOTdcb8883c.BI Type 1C WinAnsi yes yes no 651 0 APNNKB+AdvTTd7835f12 Type 1C WinAnsi yes yes no 653 0 APNNKC+AdvTTd7835f12+20 Type 1C WinAnsi yes yes no 655 0 APNNLC+AdvTT0b7bb6fa.I Type 1C WinAnsi yes yes no 657 0 Times-Roman Type 1 WinAnsi no no no 679 0 APPLIM+AdvTT2dea7504.B Type 1C WinAnsi yes yes no 485 0 APPLLE+AdvTT9a5695f7+20 Type 1C WinAnsi yes yes no 467 0 APPLLF+AdvTTb278f7d1 Type 1C WinAnsi yes yes no 472 0 APPLMG+AdvTTb278f7d1+20 Type 1C WinAnsi yes yes no 473 0 APPLMH+AdvTTa86e0a63 Type 1C WinAnsi yes yes no 469 0 APPLMI+AdvTTd7835f12 Type 1C WinAnsi yes yes no 476 0 APPLNI+AdvTT0b7bb6fa.I Type 1C WinAnsi yes yes no 466 0 APPLNJ+AdvTTd7835f12+20 Type 1C WinAnsi yes yes no 468 0 APPLPK+AdvTT82e34213.B Type 1C WinAnsi yes yes no 470 0 APPLIN+AdvTTdf37bfe4+25 Type 1C Custom yes yes yes 471 0 APPLIO+AdvTTf99636c8.B Type 1C WinAnsi yes yes no 475 0 APPLIP+AdvOT17d99a6a.B Type 1C WinAnsi yes yes no 462 0 APPLJA+AdvTT1ef22648.B Type 1C WinAnsi yes yes no 483 0 APPLJB+AdvTT9a5695f7 Type 1C WinAnsi yes yes no 481 0 APPLKB+AdvTT1ef22648.B+20 Type 1C WinAnsi yes yes no 479 0 APPLKC+AdvOTd78f143c.B+01 Type 1C Custom yes yes yes 484 0 APPLLD+AdvOTd78f143c.B Type 1C WinAnsi yes yes no 480 0 APPMDJ+AdvTTec37d199 Type 1C WinAnsi yes yes no 494 0 APPMDK+AdvTTec37d199+20 Type 1C WinAnsi yes yes no 493 0 APPMJJ+Helvetica Type 1C WinAnsi yes yes no 492 0 APPMKJ+Helvetica-Bold Type 1C WinAnsi yes yes no 497 0 APPMOJ+BentonSansCondensed-Bold Type 1C WinAnsi yes yes no 496 0 APPNDI+AdvTTf03bd20d.I Type 1C WinAnsi yes yes no 498 0 APPNHI+Helvetica-Bold Type 1C WinAnsi yes yes no 505 0 APPNHJ+Helvetica-BoldOblique Type 1C WinAnsi yes yes no 503 0 APPNIJ+Symbol Type 1C Custom yes yes yes 500 0 APPNLJ+AdvOTdcb8883c.BI Type 1C WinAnsi yes yes no 504 0 APPNLK+AdvTTcd7bcd39 Type 1C WinAnsi yes yes no 502 0 APPNOK+AdvTTd7835f12+22 Type 1C Custom yes yes no 514 0 BAABOD+AdvTTa15c7c65.I Type 1C WinAnsi yes yes no 532 0 BAACCC+AdvTTec37d199+22 Type 1C Custom yes yes no 533 0 BAACJA+Helvetica-BoldOblique Type 1C WinAnsi yes yes no 534 0 BAACMA+AdvTTec37d199+01 Type 1C Custom yes yes yes 536 0 Helvetica Type 1 WinAnsi no no no 541 0 Helvetica-Oblique Type 1 WinAnsi no no no 539 0 Helvetica-Bold Type 1 WinAnsi no no no 540 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-05 02:47:02 CET RepresentationInformation: 244126.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-04 09:19:27 CET Size: 1412861 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 5 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 7 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 580 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1172 ImageHeight: 377 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 77 ImageHeight: 70 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 75 ImageHeight: 68 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 8 ImageHeight: 7 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 6 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 613 ImageHeight: 543 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 72 ImageHeight: 68 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 72 ImageHeight: 68 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 72 ImageHeight: 70 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 15 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 962 ImageHeight: 98 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 734 ImageHeight: 90 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 978 ImageHeight: 90 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 954 ImageHeight: 95 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 727 ImageHeight: 92 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 724 ImageHeight: 95 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 601 ImageHeight: 476 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 606 ImageHeight: 506 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 273 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 293 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 284 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 259 ImageHeight: 252 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 284 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 284 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 28 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 6 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 267 ImageHeight: 258 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 8 ImageHeight: 415 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 264 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 287 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 293 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 293 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 17 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 293 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 8 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 138 ImageHeight: 64 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Fonts: Type1: Font: BaseFont: APOBHG+BentonSansCondensed-Regular FontSubset: true FirstChar: 49 LastChar: 84 FontDescriptor: FontName: APOBHG+BentonSansCondensed-Regular Flags: Nonsymbolic FontBBox: -72, -233, 1124, 967 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNOK+AdvTTd7835f12+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: APPNOK+AdvTTd7835f12+22 Flags: Nonsymbolic FontBBox: 0, -270, 1052, 1020 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: APNNIM+AdvTTdf37bfe4+25 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: APNNIM+AdvTTdf37bfe4+25 Flags: Symbolic FontBBox: 0, -291, 1010, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: APNNIN+AdvTTf99636c8.B FontSubset: true FirstChar: 65 LastChar: 86 FontDescriptor: FontName: APNNIN+AdvTTf99636c8.B Flags: Nonsymbolic FontBBox: -41, -197, 1062, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNIO+AdvOT17d99a6a.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: APNNIO+AdvOT17d99a6a.B Flags: Nonsymbolic FontBBox: -31, -197, 770, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNIP+AdvTT1ef22648.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: APNNIP+AdvTT1ef22648.B Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNJA+AdvOTdcb8883c.BI FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: APNNJA+AdvOTdcb8883c.BI Flags: Nonsymbolic FontBBox: -114, -208, 885, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNKB+AdvTTd7835f12 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: APNNKB+AdvTTd7835f12 Flags: Serif, Nonsymbolic FontBBox: -62, -208, 947, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNKC+AdvTTd7835f12+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: APNNKC+AdvTTd7835f12+20 Flags: Nonsymbolic FontBBox: -468, -208, 1468, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNLC+AdvTT0b7bb6fa.I FontSubset: true FirstChar: 47 LastChar: 116 FontDescriptor: FontName: APNNLC+AdvTT0b7bb6fa.I Flags: Serif, Nonsymbolic FontBBox: -166, -177, 1041, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BAABOD+AdvTTa15c7c65.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: BAABOD+AdvTTa15c7c65.I Flags: Nonsymbolic FontBBox: -104, -197, 854, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BAACCC+AdvTTec37d199+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: BAACCC+AdvTTec37d199+22 Flags: Nonsymbolic FontBBox: 0, -197, 614, 739 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BAACJA+Helvetica-BoldOblique FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: BAACJA+Helvetica-BoldOblique Flags: Nonsymbolic, Italic, ForceBold FontBBox: -174, -228, 1114, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BAACMA+AdvTTec37d199+01 FontSubset: true FirstChar: 1 LastChar: 154 FontDescriptor: FontName: BAACMA+AdvTTec37d199+01 Flags: Symbolic FontBBox: -62, -218, 885, 958 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Oblique Encoding: WinAnsiEncoding Font: BaseFont: Helvetica-Bold Encoding: WinAnsiEncoding Font: BaseFont: Helvetica Encoding: WinAnsiEncoding Font: BaseFont: APPLIP+AdvOT17d99a6a.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: APPLIP+AdvOT17d99a6a.B Flags: Nonsymbolic FontBBox: -31, -197, 770, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLNI+AdvTT0b7bb6fa.I FontSubset: true FirstChar: 47 LastChar: 121 FontDescriptor: FontName: APPLNI+AdvTT0b7bb6fa.I Flags: Serif, Nonsymbolic FontBBox: -166, -177, 1041, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLLE+AdvTT9a5695f7+20 FontSubset: true FirstChar: 134 LastChar: 135 FontDescriptor: FontName: APPLLE+AdvTT9a5695f7+20 Flags: Nonsymbolic FontBBox: -479, -197, 1312, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLNJ+AdvTTd7835f12+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: APPLNJ+AdvTTd7835f12+20 Flags: Nonsymbolic FontBBox: -468, -208, 1468, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLMH+AdvTTa86e0a63 FontSubset: true FirstChar: 83 LastChar: 83 FontDescriptor: FontName: APPLMH+AdvTTa86e0a63 Flags: Nonsymbolic FontBBox: -20, -187, 729, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLPK+AdvTT82e34213.B FontSubset: true FirstChar: 48 LastChar: 124 FontDescriptor: FontName: APPLPK+AdvTT82e34213.B Flags: Nonsymbolic FontBBox: -93, -239, 1177, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLIN+AdvTTdf37bfe4+25 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: APPLIN+AdvTTdf37bfe4+25 Flags: Symbolic FontBBox: 0, -291, 1010, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: APPLLF+AdvTTb278f7d1 FontSubset: true FirstChar: 37 LastChar: 182 FontDescriptor: FontName: APPLLF+AdvTTb278f7d1 Flags: Nonsymbolic FontBBox: -31, -197, 833, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLMG+AdvTTb278f7d1+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: APPLMG+AdvTTb278f7d1+20 Flags: Nonsymbolic FontBBox: 0, -197, 1187, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLIO+AdvTTf99636c8.B FontSubset: true FirstChar: 65 LastChar: 89 FontDescriptor: FontName: APPLIO+AdvTTf99636c8.B Flags: Nonsymbolic FontBBox: -41, -197, 1062, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLMI+AdvTTd7835f12 FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: APPLMI+AdvTTd7835f12 Flags: Serif, Nonsymbolic FontBBox: -62, -208, 947, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLKB+AdvTT1ef22648.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: APPLKB+AdvTT1ef22648.B+20 Flags: Nonsymbolic FontBBox: 0, -197, 1260, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLLD+AdvOTd78f143c.B FontSubset: true FirstChar: 44 LastChar: 237 FontDescriptor: FontName: APPLLD+AdvOTd78f143c.B Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLJB+AdvTT9a5695f7 FontSubset: true FirstChar: 42 LastChar: 182 FontDescriptor: FontName: APPLJB+AdvTT9a5695f7 Flags: Nonsymbolic FontBBox: -31, -197, 947, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLJA+AdvTT1ef22648.B FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: APPLJA+AdvTT1ef22648.B Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPLKC+AdvOTd78f143c.B+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: APPLKC+AdvOTd78f143c.B+01 Flags: Symbolic FontBBox: -72, -270, 895, 979 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: APPLIM+AdvTT2dea7504.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: APPLIM+AdvTT2dea7504.B Flags: Nonsymbolic FontBBox: -406, -229, 729, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNIL+AdvTT2dea7504.B FontSubset: true FirstChar: 65 LastChar: 89 FontDescriptor: FontName: APNNIL+AdvTT2dea7504.B Flags: Nonsymbolic FontBBox: -406, -229, 729, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPMJJ+Helvetica FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: APPMJJ+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNMD+AdvTTd7835f12+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: APNNMD+AdvTTd7835f12+22 Flags: Nonsymbolic FontBBox: 0, -270, 1052, 1020 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: APPMDK+AdvTTec37d199+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: APPMDK+AdvTTec37d199+20 Flags: Nonsymbolic FontBBox: 0, -197, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPMDJ+AdvTTec37d199 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: APPMDJ+AdvTTec37d199 Flags: Nonsymbolic FontBBox: -20, -197, 781, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNME+AdvTTd7835f12+25 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: APNNME+AdvTTd7835f12+25 Flags: Symbolic FontBBox: -10, -302, 1000, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: APPMOJ+BentonSansCondensed-Bold FontSubset: true FirstChar: 65 LastChar: 71 FontDescriptor: FontName: APPMOJ+BentonSansCondensed-Bold Flags: Nonsymbolic FontBBox: -74, -278, 1270, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPMKJ+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: APPMKJ+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNMF+AdvTT82e34213.B FontSubset: true FirstChar: 48 LastChar: 111 FontDescriptor: FontName: APNNMF+AdvTT82e34213.B Flags: Nonsymbolic FontBBox: -93, -239, 1177, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNDI+AdvTTf03bd20d.I FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: APPNDI+AdvTTf03bd20d.I Flags: Nonsymbolic FontBBox: -83, -197, 812, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNNG+AdvTTec37d199 FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: APNNNG+AdvTTec37d199 Flags: Nonsymbolic FontBBox: -20, -197, 781, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNIJ+Symbol FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: APPNIJ+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: APNNNH+AdvTTb278f7d1 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: APNNNH+AdvTTb278f7d1 Flags: Nonsymbolic FontBBox: -31, -197, 833, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNLK+AdvTTcd7bcd39 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: APPNLK+AdvTTcd7bcd39 Flags: Nonsymbolic FontBBox: -593, -208, 927, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNHJ+Helvetica-BoldOblique FontSubset: true FirstChar: 32 LastChar: 84 FontDescriptor: FontName: APPNHJ+Helvetica-BoldOblique Flags: Nonsymbolic, Italic, ForceBold FontBBox: -174, -228, 1114, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APNNOH+AdvTTa15c7c65.I FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: APNNOH+AdvTTa15c7c65.I Flags: Nonsymbolic FontBBox: -104, -197, 854, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNLJ+AdvOTdcb8883c.BI FontSubset: true FirstChar: 49 LastChar: 84 FontDescriptor: FontName: APPNLJ+AdvOTdcb8883c.BI Flags: Nonsymbolic FontBBox: -114, -208, 885, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APPNHI+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: APPNHI+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APOBHD+BentonSansCondensed-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: APOBHD+BentonSansCondensed-Bold Flags: Nonsymbolic FontBBox: -74, -278, 1270, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APOBHE+BentonSansCondensed-Book FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: APOBHE+BentonSansCondensed-Book Flags: Nonsymbolic FontBBox: -71, -223, 1093, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APOBHF+BentonSansCondensed-Medium FontSubset: true FirstChar: 49 LastChar: 84 FontDescriptor: FontName: APOBHF+BentonSansCondensed-Medium Flags: Nonsymbolic FontBBox: -73, -256, 1195, 979 FontFile3: true Encoding: WinAnsiEncoding XMP: 2022-03-04T00:18:41-08:00 2022-03-04T09:19:05+01:00 2022-03-04T09:19:05+01:00 iText 4.2.0 by 1T3XT application/pdf Science 2020.370:eabd4570 Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 uuid:588da3d3-b0f3-4575-ab7b-91480a449a26 uuid:564755d0-5e15-404b-87e6-37539bd923e9 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 97, 416, 169, 424 Annotation: Subtype: Link Rect: 522, 109, 544, 115 Annotation: Subtype: Link Rect: 393, 101, 504, 108 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 260, 133, 264, 142 Destination: 1 Annotation: Subtype: Link Rect: 308, 81, 313, 90 Destination: 1 Annotation: Subtype: Link Rect: 316, 81, 320, 90 Destination: 1 Annotation: Subtype: Link Rect: 350, 70, 379, 79 Annotation: Subtype: Link Rect: 214, 60, 286, 69 Annotation: Subtype: Link Rect: 457, 677, 461, 686 Destination: 1 Annotation: Subtype: Link Rect: 440, 478, 444, 487 Destination: 1 Annotation: Subtype: Link Rect: 548, 457, 552, 466 Destination: 1 Annotation: Subtype: Link Rect: 416, 447, 420, 456 Destination: 1 Annotation: Subtype: Link Rect: 469, 447, 474, 456 Destination: 1 Annotation: Subtype: Link Rect: 448, 405, 452, 414 Destination: 1 Annotation: Subtype: Link Rect: 500, 405, 508, 414 Destination: 1 Annotation: Subtype: Link Rect: 545, 405, 552, 414 Destination: 1 Annotation: Subtype: Link Rect: 416, 395, 423, 403 Destination: 1 Annotation: Subtype: Link Rect: 451, 395, 459, 403 Destination: 1 Annotation: Subtype: Link Rect: 537, 395, 545, 403 Destination: 1 Annotation: Subtype: Link Rect: 465, 374, 473, 382 Destination: 1 Annotation: Subtype: Link Rect: 517, 374, 525, 382 Destination: 1 Annotation: Subtype: Link Rect: 395, 363, 403, 372 Destination: 1 Annotation: Subtype: Link Rect: 457, 363, 465, 372 Destination: 1 Annotation: Subtype: Link Rect: 502, 290, 510, 299 Destination: 1 Thumb: true Page: Sequence: 3 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 89, 667, 94, 675 Destination: 1 Annotation: Subtype: Link Rect: 98, 667, 107, 675 Destination: 1 Annotation: Subtype: Link Rect: 305, 698, 314, 707 Destination: 1 Annotation: Subtype: Link Rect: 410, 395, 418, 403 Destination: 1 Annotation: Subtype: Link Rect: 423, 395, 432, 403 Destination: 1 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 39, 123, 48, 131 Destination: 1 Annotation: Subtype: Link Rect: 53, 123, 62, 131 Destination: 1 Annotation: Subtype: Link Rect: 180, 81, 184, 90 Destination: 1 Annotation: Subtype: Link Rect: 188, 81, 196, 90 Destination: 1 Annotation: Subtype: Link Rect: 93, 60, 98, 69 Destination: 1 Annotation: Subtype: Link Rect: 102, 60, 106, 69 Destination: 1 Annotation: Subtype: Link Rect: 110, 60, 117, 69 Destination: 1 Annotation: Subtype: Link Rect: 121, 60, 129, 69 Destination: 1 Annotation: Subtype: Link Rect: 133, 60, 142, 69 Destination: 1 Annotation: Subtype: Link Rect: 217, 70, 221, 79 Destination: 1 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 279, 301, 287, 309 Destination: 1 Annotation: Subtype: Link Rect: 291, 301, 300, 309 Destination: 1 Annotation: Subtype: Link Rect: 297, 259, 306, 267 Destination: 1 Annotation: Subtype: Link Rect: 260, 227, 269, 236 Destination: 1 Annotation: Subtype: Link Rect: 415, 321, 419, 330 Destination: 1 Annotation: Subtype: Link Rect: 424, 321, 428, 330 Destination: 1 Annotation: Subtype: Link Rect: 395, 81, 400, 90 Destination: 1 Annotation: Subtype: Link Rect: 439, 39, 448, 48 Destination: 1 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 528, 238, 537, 246 Destination: 1 Annotation: Subtype: Link Rect: 457, 196, 464, 205 Destination: 1 Annotation: Subtype: Link Rect: 482, 185, 557, 194 Annotation: Subtype: Link Rect: 393, 175, 453, 184 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 173, 238, 182, 246 Destination: 1 Annotation: Subtype: Link Rect: 135, 206, 144, 215 Destination: 1 Annotation: Subtype: Link Rect: 39, 196, 48, 205 Destination: 1 Annotation: Subtype: Link Rect: 275, 206, 283, 215 Destination: 1 Annotation: Subtype: Link Rect: 287, 206, 296, 215 Destination: 1 Annotation: Subtype: Link Rect: 541, 614, 550, 623 Destination: 1 Annotation: Subtype: Link Rect: 527, 217, 536, 226 Destination: 1 Annotation: Subtype: Link Rect: 39, 579, 47, 587 Destination: 1 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 179, 500, 200, 507 Annotation: Subtype: Link Rect: 46, 492, 90, 499 Annotation: Subtype: Link Rect: 109, 492, 133, 499 Annotation: Subtype: Link Rect: 174, 469, 199, 475 Annotation: Subtype: Link Rect: 57, 437, 133, 443 Annotation: Subtype: Link Rect: 152, 437, 177, 443 Annotation: Subtype: Link Rect: 57, 405, 122, 411 Annotation: Subtype: Link Rect: 141, 405, 166, 411 Annotation: Subtype: Link Rect: 178, 389, 200, 395 Annotation: Subtype: Link Rect: 46, 381, 98, 387 Annotation: Subtype: Link Rect: 118, 381, 143, 387 Annotation: Subtype: Link Rect: 77, 357, 132, 363 Annotation: Subtype: Link Rect: 151, 357, 174, 363 Annotation: Subtype: Link Rect: 98, 333, 155, 339 Annotation: Subtype: Link Rect: 173, 333, 197, 339 Annotation: Subtype: Link Rect: 107, 309, 164, 315 Annotation: Subtype: Link Rect: 62, 301, 86, 307 Annotation: Subtype: Link Rect: 57, 270, 101, 276 Annotation: Subtype: Link Rect: 120, 270, 143, 276 Annotation: Subtype: Link Rect: 57, 246, 118, 253 Annotation: Subtype: Link Rect: 137, 246, 161, 253 Annotation: Subtype: Link Rect: 113, 215, 190, 221 Annotation: Subtype: Link Rect: 63, 207, 88, 213 Annotation: Subtype: Link Rect: 178, 184, 200, 190 Annotation: Subtype: Link Rect: 46, 176, 79, 182 Annotation: Subtype: Link Rect: 98, 176, 122, 182 Annotation: Subtype: Link Rect: 77, 152, 133, 158 Annotation: Subtype: Link Rect: 152, 152, 176, 158 Annotation: Subtype: Link Rect: 57, 120, 121, 126 Annotation: Subtype: Link Rect: 140, 120, 164, 126 Annotation: Subtype: Link Rect: 57, 88, 114, 94 Annotation: Subtype: Link Rect: 133, 88, 157, 94 Annotation: Subtype: Link Rect: 57, 64, 131, 70 Annotation: Subtype: Link Rect: 151, 64, 176, 70 Annotation: Subtype: Link Rect: 111, 40, 151, 47 Annotation: Subtype: Link Rect: 170, 40, 195, 47 Annotation: Subtype: Link Rect: 286, 683, 350, 689 Annotation: Subtype: Link Rect: 240, 675, 264, 681 Annotation: Subtype: Link Rect: 340, 651, 377, 658 Annotation: Subtype: Link Rect: 240, 643, 263, 650 Annotation: Subtype: Link Rect: 235, 619, 296, 625 Annotation: Subtype: Link Rect: 315, 619, 339, 625 Annotation: Subtype: Link Rect: 327, 595, 379, 601 Annotation: Subtype: Link Rect: 224, 587, 243, 593 Annotation: Subtype: Link Rect: 262, 587, 286, 593 Annotation: Subtype: Link Rect: 356, 563, 379, 569 Annotation: Subtype: Link Rect: 224, 555, 259, 561 Annotation: Subtype: Link Rect: 279, 555, 303, 561 Annotation: Subtype: Link Rect: 293, 523, 368, 529 Annotation: Subtype: Link Rect: 240, 515, 263, 521 Annotation: Subtype: Link Rect: 284, 482, 357, 488 Annotation: Subtype: Link Rect: 240, 474, 264, 481 Annotation: Subtype: Link Rect: 308, 450, 361, 457 Annotation: Subtype: Link Rect: 224, 442, 245, 449 Annotation: Subtype: Link Rect: 264, 442, 289, 449 Annotation: Subtype: Link Rect: 324, 418, 374, 424 Annotation: Subtype: Link Rect: 224, 410, 245, 416 Annotation: Subtype: Link Rect: 264, 410, 287, 416 Annotation: Subtype: Link Rect: 313, 387, 374, 393 Annotation: Subtype: Link Rect: 240, 379, 265, 385 Annotation: Subtype: Link Rect: 256, 355, 321, 361 Annotation: Subtype: Link Rect: 341, 355, 366, 361 Annotation: Subtype: Link Rect: 332, 307, 371, 313 Annotation: Subtype: Link Rect: 240, 299, 264, 305 Annotation: Subtype: Link Rect: 285, 275, 362, 281 Annotation: Subtype: Link Rect: 240, 267, 263, 273 Annotation: Subtype: Link Rect: 325, 242, 369, 248 Annotation: Subtype: Link Rect: 240, 234, 264, 240 Annotation: Subtype: Link Rect: 346, 210, 371, 216 Annotation: Subtype: Link Rect: 324, 185, 377, 192 Annotation: Subtype: Link Rect: 241, 177, 265, 184 Annotation: Subtype: Link Rect: 333, 146, 353, 152 Annotation: Subtype: Link Rect: 224, 138, 273, 144 Annotation: Subtype: Link Rect: 350, 113, 371, 119 Annotation: Subtype: Link Rect: 224, 105, 278, 111 Annotation: Subtype: Link Rect: 297, 105, 320, 111 Annotation: Subtype: Link Rect: 235, 73, 284, 79 Annotation: Subtype: Link Rect: 303, 73, 326, 79 Annotation: Subtype: Link Rect: 255, 40, 325, 47 Annotation: Subtype: Link Rect: 345, 40, 369, 47 Annotation: Subtype: Link Rect: 447, 683, 513, 689 Annotation: Subtype: Link Rect: 532, 683, 555, 689 Annotation: Subtype: Link Rect: 460, 659, 534, 665 Annotation: Subtype: Link Rect: 419, 651, 444, 657 Annotation: Subtype: Link Rect: 509, 396, 530, 402 Annotation: Subtype: Link Rect: 402, 388, 443, 394 Annotation: Subtype: Link Rect: 496, 239, 546, 245 Annotation: Subtype: Link Rect: 393, 231, 461, 238 Annotation: Subtype: Link Rect: 461, 215, 506, 222 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 313, 539, 319, 545 Destination: 1 Annotation: Subtype: Link Rect: 278, 468, 376, 474 Annotation: Subtype: Link Rect: 214, 460, 234, 466 Thumb: true Page: Sequence: 12 Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 393, 472, 555, 478 Annotation: Subtype: Link Rect: 424, 440, 430, 446 Destination: External Annotation: Subtype: Link Rect: 443, 440, 449, 446 Destination: External Annotation: Subtype: Link Rect: 393, 420, 535, 426 Thumb: true Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 190, 99, 249, 106 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 190, 99, 249, 106 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 190, 99, 249, 106 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 190, 99, 249, 106 Checksum: 09dee61c Type: CRC32 Checksum: 998703f764ae5cb899664fd46b345291 Type: MD5 Checksum: d32e8c1ee7e217d5b0561df0769ee31d0fc88b9a Type: SHA-1