7d1e5267883be2518fce24df50e40f56 244130.pdf c4a5caeab2870e701efa03d0f7b2cb5b920d0a94 244130.pdf 099a27a8a2cde2ffd8463af603d7a0779b675cabbd81a9d0f7c7567a1062e39d 244130.pdf Title: Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence Subject: Critical Care, 2020, doi:10.1186/s13054-020-03148-2 Keywords: COVID-19,ARDS,SARS,Nebulised heparin,Unfractionated heparin,SARS-CoV-2 Author: Frank M. P. van Haren Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jul 21 12:27:28 2020 CEST ModDate: Wed Jul 22 12:47:33 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2576648 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HDGGCB+ShryjfAdvTT7329fd89.I Type 1C WinAnsi yes yes no 12 0 MyriadPro-Regular Type 1C Custom yes no yes 13 0 HDGDHL+PgnfxvAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 14 0 HDGFAD+LrdbghAdvTTe45e47d2 Type 1C WinAnsi yes yes no 15 0 HDGFAE+PjytlfAdvTTb5929f4c Type 1C WinAnsi yes yes no 16 0 HDGFEE+XykndfAdvTT99c4c969 Type 1C WinAnsi yes yes no 17 0 HDGFFE+NyjkmkAdvTT86d47313 Type 1C WinAnsi yes yes no 18 0 HDGFFF+CrjcqgAdvTT86d47313+20 Type 1C WinAnsi yes yes no 19 0 HDGMNL+TxrfbkAdvTT86d47313+03 Type 1C Custom yes yes yes 129 0 HDGMNK+MbbprrAdvTT8861b38f.I Type 1C WinAnsi yes yes no 135 0 HDGNAL+RvhjfbAdvTTb5929f4c+21 Type 1C Custom yes yes yes 265 0 HDGNBM+BbcljwAdvTTb5929f4c+03 Type 1C Custom yes yes yes 194 0 HDGNBN+SrmhmmAdvTTe45e47d2+21 Type 1C Custom yes yes yes 199 0 HDGNEM+SwyrrxAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 317 0 HDGNEN+CcswsyAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 319 0 HDGNKM+TmkyvxAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 388 0 HDGNMM+PnksrvAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 401 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-17 02:42:14 CET RepresentationInformation: 244130.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-16 13:26:48 CET Size: 2576648 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR50' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR51' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR52' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR53' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR54' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR55' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR56' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR57' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR53' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR58' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR59' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR60' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR64' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR58' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR65' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR66' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR72' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR73' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR74' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR60' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR75' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR78' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR79' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR79' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR80' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR78' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR78' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR78' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR81' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR82' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR83' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR84' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR85' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR85' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR89' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR90' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR91' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR90' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR92' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR93' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR94' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR95' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR96' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR97' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR98' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR102' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR103' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR104' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR105' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR106' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR107' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR80' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR108' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR109' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR110' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR111' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR112' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR113' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR114' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR100' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR115' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR101' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR116' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR117' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR118' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR119' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR120' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR121' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR122' cannot be found Offset: 2405500 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR123' cannot be found Offset: 2405500 MIMEtype: application/pdf PDFMetadata: Objects: 629 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Biological rationale: pathophysiology of COVID-19 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Infection, inflammation and coagulopathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Hyaline membrane formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Microvascular thrombosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Mucus exudates and DNA NETs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Biological rationale: effects of nebulised UFH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Anti-viral effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Anti-inflammatory effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Anti-coagulant effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Mucolytic effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Pre-clinical and clinical evidence in lung injury Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Clinical evidence in SARS-CoV-2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence Author: Frank M. P. van Haren Subject: Critical Care, 2020, doi:10.1186/s13054-020-03148-2 Keywords: COVID-19,ARDS,SARS,Nebulised heparin,Unfractionated heparin,SARS-CoV-2 Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jul 21 12:27:28 CEST 2020 ModDate: Wed Jul 22 12:47:33 CEST 2020 ID: 0xf1d481c8da5cd82c58559f6bff3875fe, 0x8a85b1eb6d056f47b72064417c57b7d2 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1949 ImageHeight: 916 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: HDGMNL+TxrfbkAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: HDGMNL+TxrfbkAdvTT86d47313+03 Flags: Symbolic FontBBox: -364, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HDGNBM+BbcljwAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: HDGNBM+BbcljwAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HDGNKM+TmkyvxAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HDGNKM+TmkyvxAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGMNK+MbbprrAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HDGMNK+MbbprrAdvTT8861b38f.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGNBN+SrmhmmAdvTTe45e47d2+21 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: HDGNBN+SrmhmmAdvTTe45e47d2+21 Flags: Symbolic FontBBox: -20, -208, 1208, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HDGNAL+RvhjfbAdvTTb5929f4c+21 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: HDGNAL+RvhjfbAdvTTb5929f4c+21 Flags: Symbolic FontBBox: -20, -208, 1208, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HDGGCB+ShryjfAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: HDGGCB+ShryjfAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HDGDHL+PgnfxvAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HDGDHL+PgnfxvAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGFAD+LrdbghAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: HDGFAD+LrdbghAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGFAE+PjytlfAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: HDGFAE+PjytlfAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGFEE+XykndfAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HDGFEE+XykndfAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGNMM+PnksrvAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: HDGNMM+PnksrvAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGFFE+NyjkmkAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: HDGFFE+NyjkmkAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGFFF+CrjcqgAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: HDGFFF+CrjcqgAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGNEM+SwyrrxAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: HDGNEM+SwyrrxAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HDGNEN+CcswsyAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: HDGNEN+CcswsyAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: COVID-19,ARDS,SARS,Nebulised heparin,Unfractionated heparin,SARS-CoV-2 Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13054-020-03148-2 Critical Care Critical Care, 2020, doi:10.1186/s13054-020-03148-2 COVID-19 ARDS SARS Nebulised heparin Unfractionated heparin SARS-CoV-2 Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence Frank M. P. van Haren Clive Page John G. Laffey Antonio Artigas Marta Camprubi-Rimblas Quentin Nunes Roger Smith Janis Shute Mary Carroll Julia Tree Miles Carroll Dave Singh Tom Wilkinson Barry Dixon 2020-07-22T12:47:33+02:00 2020-07-22T12:47:33+02:00 2020-07-21T18:27:28+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:44e539f9-73af-4ae0-9c5c-416dff756d3e uuid:1fc5bac7-b598-4408-8ae4-d82b2cb5083e default 1 converted uuid:44e539f9-73af-4ae0-9c5c-416dff756d3e converted to PDF/A-2b pdfToolbox 2020-07-21T19:25:15+08:00 2 B Frank M. P. van Haren http://orcid.org/0000-0001-8037-4229 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 159, 573, 168, 582 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 394, 212, 399, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 405, 212, 410, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 378, 140, 383, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 393, 140, 398, 150 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 165, 196, 172 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 98, 681, 103, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 234, 633, 239, 642 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 246, 633, 251, 642 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 179, 561, 184, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 191, 561, 196, 570 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 202, 561, 212, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 131, 453, 141, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 147, 453, 157, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 416, 645, 425, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 386, 537, 391, 546 Flags: Print AppearanceDictionary: true Destination: 6 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 174, 669, 183, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 188, 669, 198, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 101, 609, 111, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 549, 149, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 192, 477, 197, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 202, 477, 207, 486 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 213, 477, 223, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 477, 238, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 244, 477, 253, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 441, 172, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 155, 381, 160, 390 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 117, 345, 127, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 132, 345, 142, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 321, 250, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 127, 273, 137, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 273, 152, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 213, 69, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 75, 213, 85, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 88, 141, 98, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 103, 141, 113, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 119, 141, 129, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 69, 166, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 382, 669, 391, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 669, 411, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 415, 609, 425, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 340, 513, 350, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 355, 513, 364, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 522, 441, 532, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 304, 429, 314, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 496, 393, 506, 402 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 383, 321, 393, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 398, 321, 408, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 475, 297, 485, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 491, 297, 500, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 415, 261, 425, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 430, 261, 440, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 336, 213, 345, 222 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 351, 213, 360, 222 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 393, 189, 403, 198 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 524, 105, 533, 114 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 379, 69, 384, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 69, 399, 78 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 404, 69, 413, 78 Flags: Print AppearanceDictionary: true Destination: 276 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 89, 633, 98, 642 Flags: Print AppearanceDictionary: true Destination: 276 Annotation: Subtype: Link Rect: 127, 597, 137, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 525, 144, 534 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 150, 525, 160, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 166, 525, 176, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 465, 259, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 193, 429, 203, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 124, 357, 129, 366 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 222, 237, 232, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 201, 150, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 254, 165, 264, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 129, 150, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 81, 172, 90 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 357, 669, 367, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 490, 645, 499, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 505, 645, 515, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 486, 585, 496, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 502, 585, 512, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 549, 317, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 549, 332, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 347, 489, 357, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 363, 489, 373, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 453, 533, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 393, 317, 402 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 141, 441, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 449, 141, 459, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 465, 141, 475, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 419, 93, 429, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 422, 57, 432, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 441, 57, 451, 66 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 231, 645, 241, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 107, 597, 117, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 549, 236, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 549, 251, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 232, 489, 242, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 88, 429, 98, 438 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 201, 297, 211, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 297, 229, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 112, 201, 122, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 201, 138, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 129, 69, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 217, 93, 227, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 495, 693, 505, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 411, 633, 421, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 426, 633, 436, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 585, 475, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 357, 513, 362, 522 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 373, 477, 378, 486 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 388, 477, 398, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 404, 477, 414, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 429, 417, 438, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 345, 411, 354 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 426, 345, 436, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 345, 457, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 377, 177, 387, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 117, 493, 126 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 223, 177, 227, 186 Flags: Print AppearanceDictionary: true Destination: 275 Annotation: Subtype: Link Rect: 512, 635, 524, 643 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 603, 524, 611 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 571, 524, 579 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 495, 530, 506, 538 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 498, 529, 506 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 452, 533, 460 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 411, 524, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 370, 533, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 320, 533, 328 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 279, 524, 287 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 220, 524, 228 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 521, 644, 532, 652 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 594, 532, 602 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 503, 553, 515, 561 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 530, 532, 538 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 434, 532, 442 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 393, 532, 401 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 352, 532, 360 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 311, 532, 319 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 503, 261, 515, 269 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 503, 220, 515, 228 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 188, 532, 196 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 133, 532, 141 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 441, 151, 538, 158 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 142, 333, 149 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 343, 87, 483, 94 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 248, 603, 279, 610 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 594, 164, 601 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 575, 246, 583 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 548, 284, 555 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 539, 119, 546 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 168, 457, 249, 465 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 448, 126, 456 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 258, 421, 289, 429 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 412, 133, 420 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 107, 358, 230, 365 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 245, 321, 288, 329 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 312, 123, 320 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 188, 276, 256, 284 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 267, 118, 275 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 79, 195, 200, 202 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 612, 530, 619 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 603, 404, 610 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 548, 493, 556 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 418, 512, 514, 519 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 449, 499, 456 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 462, 412, 538, 420 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 403, 336, 411 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 92, 666, 193, 674 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 521, 256, 528 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 494, 375, 537, 383 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 366, 395, 374 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 494, 330, 538, 337 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 321, 395, 328 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 319, 153, 445, 161 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 3d4aa139 Type: CRC32 Checksum: 7d1e5267883be2518fce24df50e40f56 Type: MD5 Checksum: c4a5caeab2870e701efa03d0f7b2cb5b920d0a94 Type: SHA-1