2ed984aa46ba0652dd3e4f38bf287671 pmc_32364844.pdf 5783697254bbddb92ad6ef2ba7668692d156269f pmc_32364844.pdf 6c278a70671ab5c754daa857b6dbe0fa1aac94333afe028021614366d90d92d3 pmc_32364844.pdf Title: PD-1 Blockade in Anaplastic Thyroid Carcinoma Subject: JCO 2020.38:2620-2627 Author: Jaume Capdevila, Lori J. Wirth, Thomas Ernst, Santiago Ponce Aix, Chia-Chi Lin, Rodryg Ramlau, Marcus O. Butler, Jean-Pierre Delord, Hans Gelderblom, Paolo A. Ascierto, Angelica Fasolo, Dagmar Führer, Marie Luise Hütter-Krönke, Patrick M. Forde, Anna Wrona, Armando Santoro, Peter M. Sadow, Sebastian Szpakowski, Hongqian Wu, Geraldine Bostel, Jason Faris, Scott Cameron, Andreea Varga, and Matthew Taylor Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Wed Jul 15 11:29:54 2020 CEST ModDate: Mon Feb 21 15:02:44 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 821005 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NOEMMB+AdvOT463cc31e Type 1C WinAnsi yes yes no 77 0 NOENFA+AdvOT53f3fec7 Type 1C WinAnsi yes yes no 78 0 NOEMNB+AdvOTd710a12c+20 Type 1C WinAnsi yes yes no 79 0 NOENFB+AdvOT53f3fec7+fb Type 1C Custom yes yes yes 80 0 NOEMNC+AdvOT8817665d Type 1C WinAnsi yes yes no 81 0 NOEMKL+AdvTT4350c63d Type 1C WinAnsi yes yes no 82 0 NOEMLM+AdvOTb03e4648.B Type 1C WinAnsi yes yes no 83 0 NOEMLN+AdvOT8a0d451b.B Type 1C WinAnsi yes yes no 84 0 NOEMLO+AdvOTd710a12c Type 1C WinAnsi yes yes no 85 0 NOEMLP+AdvOTa82dc243.I Type 1C WinAnsi yes yes no 86 0 NOEMMA+AdvOTd710a12c+fb Type 1C Custom yes yes yes 87 0 Times-Roman Type 1 WinAnsi no no no 5 0 NOEODN+AdvPS7DA6 Type 1C WinAnsi yes yes no 120 0 NOEOFN+AdvOT8a0d451b.B+fb Type 1C Custom yes yes yes 126 0 NOEOHN+AdvOT9d186844 Type 1C WinAnsi yes yes no 134 0 NOEOLC+SymbolMT CID TrueType Identity-H yes yes yes 142 0 NOEOLA+Univers-Bold Type 1C WinAnsi yes yes no 143 0 NOEOLB+Univers-BoldOblique Type 1C WinAnsi yes yes no 144 0 NOEOJO+Univers Type 1C Custom yes yes no 145 0 NOEOKP+Univers-Condensed Type 1C WinAnsi yes yes no 146 0 NOEOJN+Helvetica-Bold Type 1C WinAnsi yes yes no 147 0 NOEPBC+ArialMT TrueType WinAnsi yes yes no 152 0 NOEPBB+ArialMT CID TrueType Identity-H yes yes yes 153 0 NOEPIB+AdvOTb03e4648.B+20 Type 1C WinAnsi yes yes no 163 0 NOEPHA+AdvOT53f3fec7+20 Type 1C WinAnsi yes yes no 164 0 NOEPKB+AdvPSUnvNCp Type 1C WinAnsi yes yes no 179 0 NOEPLC+AdvOT8a0d451b.B+20 Type 1C WinAnsi yes yes no 183 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-22 02:32:52 CET RepresentationInformation: pmc_32364844.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-21 15:03:17 CET Size: 821005 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: PD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Clinical Study Design and Oversight Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Study Objectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Treatment Plan Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Safety and Response Assessments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Pharmacodynamic and Biomarker Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Statistical Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: Patient Characteristics and Disposition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Safety and Tolerability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Biomarker Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: jcojcoJCOJournal of Clinical Oncology0732-183XAmerican Society of Clinical Oncology190272710.1200/JCO.19.02727HNC18Immunoth ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: NOEPBB+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: NOEOLC+SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NOEPIB+AdvOTb03e4648.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: NOEPIB+AdvOTb03e4648.B+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEPHA+AdvOT53f3fec7+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: NOEPHA+AdvOT53f3fec7+20 Flags: Nonsymbolic FontBBox: -166, -135, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOHN+AdvOT9d186844 FontSubset: true FirstChar: 53 LastChar: 53 FontDescriptor: FontName: NOEOHN+AdvOT9d186844 Flags: Nonsymbolic FontBBox: -20, -239, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMMB+AdvOT463cc31e FontSubset: true FirstChar: 44 LastChar: 53 FontDescriptor: FontName: NOEMMB+AdvOT463cc31e Flags: Nonsymbolic FontBBox: -20, -239, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOENFA+AdvOT53f3fec7 FontSubset: true FirstChar: 38 LastChar: 180 FontDescriptor: FontName: NOENFA+AdvOT53f3fec7 Flags: Nonsymbolic FontBBox: -10, -218, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMNB+AdvOTd710a12c+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: NOEMNB+AdvOTd710a12c+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOLA+Univers-Bold FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: NOEOLA+Univers-Bold Flags: Nonsymbolic, ForceBold FontBBox: -167, -250, 995, 938 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOENFB+AdvOT53f3fec7+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NOENFB+AdvOT53f3fec7+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOEOLB+Univers-BoldOblique FontSubset: true FirstChar: 65 LastChar: 82 FontDescriptor: FontName: NOEOLB+Univers-BoldOblique Flags: Nonsymbolic, Italic, ForceBold FontBBox: -173, -250, 1148, 938 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMNC+AdvOT8817665d FontSubset: true FirstChar: 35 LastChar: 36 FontDescriptor: FontName: NOEMNC+AdvOT8817665d Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOJO+Univers FontSubset: true FirstChar: 21 LastChar: 150 FontDescriptor: FontName: NOEOJO+Univers Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NOEMKL+AdvTT4350c63d FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: NOEMKL+AdvTT4350c63d Flags: Serif, Nonsymbolic FontBBox: -31, -302, 895, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOKP+Univers-Condensed FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: NOEOKP+Univers-Condensed Flags: Nonsymbolic FontBBox: -166, -250, 1000, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMLM+AdvOTb03e4648.B FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: NOEMLM+AdvOTb03e4648.B Flags: Nonsymbolic FontBBox: -52, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOJN+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 66 FontDescriptor: FontName: NOEOJN+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEPKB+AdvPSUnvNCp FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: NOEPKB+AdvPSUnvNCp Flags: Nonsymbolic FontBBox: 0, -218, 989, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMLN+AdvOT8a0d451b.B FontSubset: true FirstChar: 44 LastChar: 168 FontDescriptor: FontName: NOEMLN+AdvOT8a0d451b.B Flags: Nonsymbolic FontBBox: -31, -218, 895, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMLO+AdvOTd710a12c FontSubset: true FirstChar: 37 LastChar: 169 FontDescriptor: FontName: NOEMLO+AdvOTd710a12c Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMLP+AdvOTa82dc243.I FontSubset: true FirstChar: 47 LastChar: 118 FontDescriptor: FontName: NOEMLP+AdvOTa82dc243.I Flags: Nonsymbolic FontBBox: -52, -270, 1041, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEMMA+AdvOTd710a12c+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: NOEMMA+AdvOTd710a12c+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOEPLC+AdvOT8a0d451b.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: NOEPLC+AdvOT8a0d451b.B+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEODN+AdvPS7DA6 FontSubset: true FirstChar: 98 LastChar: 103 FontDescriptor: FontName: NOEODN+AdvPS7DA6 Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOEOFN+AdvOT8a0d451b.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NOEOFN+AdvOT8a0d451b.B+fb Flags: Symbolic FontBBox: 9, 0, 489, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true TrueType: Font: BaseFont: NOEPBC+ArialMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: NOEPBC+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: NOEOLC+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NOEOLC+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true Font: BaseFont: NOEPBB+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NOEPBB+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true XMP: application/pdfdoi:10.1200/JCO.19.02727 10.1200/JCO.19.02727https://doi.org/10.1200/JCO.19.02727 2020-05-04trueascopubs.org10.1200/JCO.19.02727 ascopubs.orgtrue10.1200/JCO.19.027272020-05-04 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 184, 259, 187, 268 Destination: 57 Annotation: Subtype: Link Rect: 189, 259, 192, 268 Destination: 57 Annotation: Subtype: Link Rect: 198, 236, 201, 244 Destination: 57 Annotation: Subtype: Link Rect: 170, 200, 173, 208 Destination: 57 Annotation: Subtype: Link Rect: 175, 200, 178, 208 Destination: 57 Annotation: Subtype: Link Rect: 211, 188, 214, 196 Destination: 57 Annotation: Subtype: Link Rect: 216, 188, 219, 196 Destination: 57 Annotation: Subtype: Link Rect: 322, 152, 326, 160 Destination: 57 Annotation: Subtype: Link Rect: 536, 286, 539, 295 Destination: 57 Annotation: Subtype: Link Rect: 541, 286, 548, 295 Destination: 57 Annotation: Subtype: Link Rect: 469, 262, 476, 271 Destination: 57 Annotation: Subtype: Link Rect: 478, 262, 484, 271 Destination: 57 Annotation: Subtype: Link Rect: 412, 215, 419, 223 Destination: 57 Annotation: Subtype: Link Rect: 541, 179, 548, 187 Destination: 57 Annotation: Subtype: Link Rect: 395, 124, 402, 132 Destination: 57 Annotation: Subtype: Link Rect: 54, 230, 70, 237 Annotation: Subtype: Link Rect: 36, 218, 89, 225 Annotation: Subtype: Link Rect: 36, 206, 62, 213 Annotation: Subtype: Link Rect: 36, 102, 103, 110 Annotation: Subtype: Link Rect: 36, 92, 46, 100 Annotation: Subtype: Link Rect: 49, 82, 104, 90 Annotation: Subtype: Link Rect: 36, 72, 99, 80 Annotation: Subtype: Link Rect: 482, 769, 582, 747 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 223, 674, 283, 683 Annotation: Subtype: Link Rect: 113, 502, 120, 511 Destination: 57 Annotation: Subtype: Link Rect: 466, 156, 472, 165 Destination: 57 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 223, 478, 252, 488 Destination: 53 Annotation: Subtype: Link Rect: 273, 144, 302, 153 Destination: 53 Annotation: Subtype: Link Rect: 368, 392, 393, 401 Destination: 54 Annotation: Subtype: Link Rect: 356, 196, 382, 205 Destination: 54 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 267, 255, 293, 264 Destination: 54 Annotation: Subtype: Link Rect: 528, 462, 535, 470 Destination: 57 Annotation: Subtype: Link Rect: 386, 140, 406, 149 Destination: 55 Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 162, 184, 182, 193 Destination: 55 Annotation: Subtype: Link Rect: 231, 112, 237, 120 Destination: 57 Annotation: Subtype: Link Rect: 239, 112, 246, 120 Destination: 57 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 157, 562, 163, 570 Destination: 57 Annotation: Subtype: Link Rect: 245, 486, 252, 495 Destination: 57 Annotation: Subtype: Link Rect: 507, 709, 511, 717 Destination: 57 Annotation: Subtype: Link Rect: 513, 709, 516, 717 Destination: 57 Annotation: Subtype: Link Rect: 335, 648, 342, 657 Destination: 57 Annotation: Subtype: Link Rect: 369, 624, 376, 632 Destination: 57 Annotation: Subtype: Link Rect: 378, 624, 385, 632 Destination: 57 Annotation: Subtype: Link Rect: 243, 88, 285, 96 Annotation: Subtype: Link Rect: 77, 78, 115, 86 Annotation: Subtype: Link Rect: 317, 288, 368, 295 Annotation: Subtype: Link Rect: 469, 231, 548, 238 Annotation: Subtype: Link Rect: 317, 221, 366, 228 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 376, 427, 443, 434 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 306, 690, 358, 697 Annotation: Subtype: Link Rect: 369, 690, 484, 697 Annotation: Subtype: Link Rect: 477, 678, 524, 685 Thumb: true Checksum: 8e68bbd9 Type: CRC32 Checksum: 2ed984aa46ba0652dd3e4f38bf287671 Type: MD5 Checksum: 5783697254bbddb92ad6ef2ba7668692d156269f Type: SHA-1