ed3ca0930696ed26b593dfafe13453f8 252401.pdf bc48d30f71a7aad37bda60efcd9c409e2eed5a8b 252401.pdf d954f81b1daf14d9404ef9a45aa069f01deec1db7bf19cd9f221a85be7ce9af4 252401.pdf Title: The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review Subject: Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding. Keywords: microbiome; pregnancy; fetus; placenta; newborn; infancy; critical illness; sepsis; allergy Author: María Dolores Mesa, Begoña Loureiro, Iris Iglesia, Sergi Fernandez Gonzalez, Elisa Llurba Olivé, Oscar García Algar, María José Solana, Mª Jesús Cabero Perez, Talia Sainz, Leopoldo Martinez, Diana Escuder-Vieco, Anna Parra-Llorca, María Sánchez-Campillo, Gerardo Rodriguez Martinez, Dolores Gómez Roig, Myriam Perez Gruz, Vicente Andreu-Fernández, Jordi Clotet, Sebastian Sailer, Isabel Iglesias-Platas, Jesús López-Herce, Rosa Aras, Carmen Pallás-Alonso, Miguel Saenz de Pipaon, Máximo Vento, María Gormaz, Elvira Larqué Daza, Cristina Calvo and Fernando Cabañas Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Jan 2 12:31:08 2020 CET ModDate: Thu Jan 2 12:31:08 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 525061 bytes Optimized: no PDF 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ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐひづでのちのっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ざちでどのちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くひちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐぬちっづのぴちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰うづぴちぬぜ〴ぜ〰ぃはぬはのどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ざちでどのちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くひちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐぬちっづのぴちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰うづぴちぬぜ〴ぜ〰ぃはぬはのどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ざちでどのちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くひちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐぬちっづのぴちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰うづぴちぬぜ〴ぜ〰ぃはぬはのどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くひちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐぬちっづのぴちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰うづぴちぬぜ〴ぜ〰ぃはぬはのどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐぬちっづのぴちぬぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰うづぴちぬぜ〴ぜ〰ぃはぬはのどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ごべばづぜ〴ぜ〰はてぜ〴ぜ〰いづぬどぶづひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰ごべばづぜ〴ぜ〰はてぜ〴ぜ〰うづづつどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: きどっひはぢどはねづぜ〴ぜ〰どのぜ〴ぜ〰ぐちぴとはぬはでどっちぬぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつぶづひびづぜ〴ぜ〰ぐひづでのちのっべぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰くぢづびづぜ〴ぜ〰ぐひづでのちのっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸷ Item: Title: きどっひはぢどはねづぜ〴ぜ〰どのぜ〴ぜ〰ぃひどぴどっちぬぜ〴ぜ〰ぉぬぬぜ〴ぜ〰ぃとどぬつひづのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸸ Item: Title: きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰こづばびどびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎづぷぢはひのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸹ Item: Title: きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁぬぬづひでどっぜ〴ぜ〰ぃはのつどぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁぴはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮㈩‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰うははつぜ〴ぜ〰ぁぬぬづひでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮㌩‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁびぴとねちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱〩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてづっぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉのてちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Children: Item: Title: ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁぴはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮㈩‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰うははつぜ〴ぜ〰ぁぬぬづひでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮㌩‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁびぴとねちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱〩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてづっぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉのてちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰うははつぜ〴ぜ〰ぁぬぬづひでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㤮㌩‾㸊⡜㌷㙜㌷㝜〰ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁびぴとねちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱〩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてづっぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉのてちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぇふぴぜ〴ぜ〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁびぴとねちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱〩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてづっぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉのてちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: きどっひはぢどはねづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてづっぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉのてちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸱ㄩ‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げづてづひづのっづび Filters: FilterPipeline: 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341, 118 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 233, 701, 271, 712 Annotation: Subtype: Link Rect: 277, 701, 313, 712 Annotation: Subtype: Link Rect: 109, 663, 147, 673 Annotation: Subtype: Link Rect: 136, 625, 174, 635 Annotation: Subtype: Link Rect: 432, 585, 469, 596 Annotation: Subtype: Link Rect: 309, 546, 346, 557 Annotation: Subtype: Link Rect: 285, 508, 323, 519 Annotation: Subtype: Link Rect: 374, 469, 411, 480 Annotation: Subtype: Link Rect: 168, 444, 205, 454 Annotation: Subtype: Link Rect: 211, 444, 247, 454 Annotation: Subtype: Link Rect: 76, 402, 166, 433 Annotation: Subtype: Link Rect: 234, 396, 407, 407 Checksum: 8b32896c Type: CRC32 Checksum: ed3ca0930696ed26b593dfafe13453f8 Type: MD5 Checksum: bc48d30f71a7aad37bda60efcd9c409e2eed5a8b Type: SHA-1