c759619f687d6ff12fa1a083ad3b922d  252433.pdf
61255d689e7ffb4f89a0fbcd17d42dae7f56aa11  252433.pdf
0ac00c42d674dd828a6d2659913a5fa14a2b98a3ac55ce2d2803f9234a86ca58  252433.pdf

Title:          Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure
Subject:        Scientific Reports, doi:10.1038/s41598-020-58696-y
Keywords:       
Author:         Concepcion Casado
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Wed Jan 29 06:45:55 2020 CET
ModDate:        Thu Jan 30 16:34:45 2020 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      2615008 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
VNJEVX+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes    125  0
QPMPOS+Corbel-BoldItalic             Type 1C           WinAnsi          yes yes yes    525  0
EuclidSymbol-Bold                    Type 1C           Custom           yes no  yes    526  0
CKPWKD+Corbel-Bold2                  Type 1C           WinAnsi          yes yes yes     64  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     63  0
NFFRXQ+Corbel2                       Type 1C           WinAnsi          yes yes yes     66  0
ZVNHZP+Corbel                        CID TrueType      Identity-H       yes yes yes     67  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     68  0
EuclidSymbol                         Type 1C           Custom           yes no  yes     62  0
MinionPro-It                         Type 1C           Custom           yes no  yes     65  0
CIDZKJ+STIXGeneral-Regular           Type 1C           Custom           yes yes yes    126  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes    159  0
EuclidSymbol-Italic                  Type 1C           Custom           yes no  yes    188  0
RPZXMF+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes yes    352  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-09-13 02:32:20 CEST
 RepresentationInformation: 252433.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-09-05 11:03:45 CEST
  Size: 2615008
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	13.	Salgado, M. et al. Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant. Ann. Intern. Med. 169, 674–683, https://doi.org/10.7326/M18-0759 (2018).
:55' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	10.	Pernas, M. et al. Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection. J. Virol. 92, 1805–1817, https://doi.org/10.1128/JVI.01805-17 (2018).
:62' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:
Table 1. Clinical, epidemiological and host-genetic characteristics. aViral dating performed in the last sample and estimated according to17. bNo further expositions after HIV-1 diagnosis. c“1” indicates the mo:69' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the detect:70' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:
Table 1. Clinical, epidemiological and host-genetic characteristics. aViral dating performed in the last sample and estimated according to17. bNo further expositions after HIV-1 diagnosis. c“1” indicates the m:71' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	9.	Casado, C. et al. Host and viral genetic correlates of clinical definitions of HIV-1 disease progression. PLoS One 5, e11079 (2010).
:74' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:
Table 1. Clinical, epidemiological and host-genetic characteristics. aViral dating performed in the last sample and estimated according to17. bNo further expositions after HIV-1 diagnosis. c“1” indicates the :76' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:
Table 1. Clinical, epidemiological and host-genetic characteristics. aViral dating performed in the last sample and estimated according to17. bNo further expositions after HIV-1 diagnosis. c“1” indicates the:78' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	25.	Pereyra, F. et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Sci. 330, 1551–1557 (2010).
:80' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the detec:82' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the dete:83' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the det:84' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the de:85' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	17.	Bello, G. et al. Co-existence of recent and ancestral nucleotide sequences in viral quasispecies of human immunodeficiency virus type 1 patients. J. Gen. Virol. 85, 399–407 (2004).
:89' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:
Table 1. Clinical, epidemiological and host-genetic characteristics. aViral dating performed in the last sample and estimated according to17. bNo further expositions after HIV-1 diagnosis. c“1” indicates th:90' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 2. Genetic variability and evolutionary dynamics of viral populations (A) Phylogenetic trees with env gene sequences of the individuals during follow-up. The evolutionary history was inferred in trees by using the Maximum Likelihood :94' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 2. Genetic variability and evolutionary dynamics of viral populations (A) Phylogenetic trees with env gene sequences of the individuals during follow-up. The evolutionary history was inferred in trees by using the Maximum Likelihood:95' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 3. Cellular Immune responses. (A) Total CD8+ T-cell Gag-specific response from EEC and HIV-1-infected individuals on suppressive ART. (B) INDEX of polyfuncionality (pINDEX) of Gag-specific total CD8+ T-cells from EEC and HIV-1-infe:97' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 3. Cellular Immune responses. (A) Total CD8+ T-cell Gag-specific response from EEC and HIV-1-infected individuals on suppressive ART. (B) INDEX of polyfuncionality (pINDEX) of Gag-specific total CD8+ T-cells from EEC and HIV-1-inf:99' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 3. Cellular Immune responses. (A) Total CD8+ T-cell Gag-specific response from EEC and HIV-1-infected individuals on suppressive ART. (B) INDEX of polyfuncionality (pINDEX) of Gag-specific total CD8+ T-cells from EEC and HIV-1-in:100' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 2. Genetic variability and evolutionary dynamics of viral populations (A) Phylogenetic trees with env gene sequences of the individuals during follow-up. The evolutionary history was inferred in trees by using the Maximum Likelihoo:102' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 4. Inflammation biomarkers and antibody titers. (A–E) Different inflammatory markers were analyzed including (A) hsCPR, (B) β2-microglobulin, (C) D-dimer, (D) IL-6 and (E) sCD163. EEC individuals were compared with HIV-1-in:104' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 4. Inflammation biomarkers and antibody titers. (A–E) Different inflammatory markers were analyzed including (A) hsCPR, (B) β2-microglobulin, (C) D-dimer, (D) IL-6 and (E) sCD163. EEC individuals were compared with HIV-1-i:105' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	26.	Moron-Lopez, S. et al. Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4+ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy. J. Infect. D:106' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 1. Clinical characteristics and HIV-1 reservoir quantification. (A–C) Plasma RNA viral load, absolute CD4+ and CD4+ T cell percentage over time in the individuals studied. Grey symbols for viral load indicate values below the d:111' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	15.	Sandonis, V. et al. A combination of defective DNA and protective host factors are found in a set of HIV-1 ancestral LTNPs. Virology 391, 73–82 (2009).
:112' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 2. Genetic variability and evolutionary dynamics of viral populations (A) Phylogenetic trees with env gene sequences of the individuals during follow-up. The evolutionary history was inferred in trees by using the Maximum Likeliho:120' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	4.	Gupta, R. K. et al. HIV-1 remission following CCR5Delta32/Delta32 haematopoietic stem-cell transplantation. Nat. 568, 244–248, https://doi.org/10.1038/s41586-019-1027-4 (2019).
:128' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 3. Cellular Immune responses. (A) Total CD8+ T-cell Gag-specific response from EEC and HIV-1-infected individuals on suppressive ART. (B) INDEX of polyfuncionality (pINDEX) of Gag-specific total CD8+ T-cells from EEC and HIV-1-:130' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:	10.	Pernas, M. et al. Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection. J. Virol. 92, 1805–1817, https://doi.org/10.1128/JVI.01805-17 (2018).
:131' cannot be found
   Offset: 2263336
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_58696.indd:Figure 4. Inflammation biomarkers and antibody titers. (A–E) Different inflammatory markers were analyzed including (A) hsCPR, (B) β2-microglobulin, (C) D-dimer, (D) IL-6 and (E) sCD163. EEC individuals were compared with HIV-1-:133' cannot be found
   Offset: 2263336
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 633
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure
      Children: 
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Individuals, samples and clinical characteristics. 
         Item: 
          Title: Viral persistence. 
          Children: 
           Item: 
            Title: Total proviral HIV-1 DNA. 
           Item: 
            Title: Quantitative Viral Outgrowth Assay (qVOA). 
           Item: 
            Title: Plasma viral load and residual viremia. 
           Item: 
            Title: Cell-Associated HIV-1 RNA. 
         Item: 
          Title: Genetic studies. 
          Children: 
           Item: 
            Title: Nucleotide sequence and phylogenetic analysis in env gene. 
           Item: 
            Title: Quasispecies diversity analysis. 
         Item: 
          Title: Immune responses. 
          Children: 
           Item: 
            Title: Cell stimulation. 
           Item: 
            Title: Immunophenotyping and intracellular cytokine staining. 
         Item: 
          Title: Susceptibility and viral inhibition assay. 
         Item: 
          Title: Assay of soluble biomarkers. 
         Item: 
          Title: HIV-1 antibody determination. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Clinical characteristics of the individuals. 
         Item: 
          Title: Viral persistence. 
         Item: 
          Title: Sequence analysis, genetic variability and evolutionary dynamics of viral populations. 
         Item: 
          Title: Evolution of immune responses. 
          Children: 
           Item: 
            Title: HIV-1-specific T-cell responses and poly-functionality. 
           Item: 
            Title: CD4+ susceptibility and CD8+ viral inhibition. 
           Item: 
            Title: Myeloid cell quantification. 
           Item: 
            Title: Inflammation biomarkers. 
           Item: 
            Title: HIV-1-specific antibody levels. 
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Clinical characteristics and HIV-1 reservoir quantification.
       Item: 
        Title: Figure 2 Genetic variability and evolutionary dynamics of viral populations (A) Phylogenetic trees with env gene sequences of the individuals during follow-up.
       Item: 
        Title: Figure 3 Cellular Immune responses.
       Item: 
        Title: Figure 4 Inflammation biomarkers and antibody titers.
       Item: 
        Title: Table 1 Clinical, epidemiological and host-genetic characteristics.
   Info: 
    Title: Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure
    Author: Concepcion Casado
    Subject: Scientific Reports, doi:10.1038/s41598-020-58696-y
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Wed Jan 29 07:15:55 CET 2020
    ModDate: Thu Jan 30 16:34:45 CET 2020
   ID: 0xfac3f2e3f5f781573904499351e02779, 0x3e5e9b6e5910e6ce875cb35ad7c2eebc
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1900
      ImageHeight: 1189
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1650
      ImageHeight: 2255
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1900
      ImageHeight: 1046
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1900
      ImageHeight: 1192
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ZVNHZP+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: VNJEVX+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: CKPWKD+Corbel-Bold2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CKPWKD+Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: RPZXMF+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: RPZXMF+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NFFRXQ+Corbel2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: NFFRXQ+Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol-Italic
       Flags: Symbolic, Italic
       FontBBox: -166, -276, 1162, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QPMPOS+Corbel-BoldItalic
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: QPMPOS+Corbel-BoldItalic
       Flags: Nonsymbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol-Bold
       Flags: Symbolic
       FontBBox: -186, -308, 1101, 960
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CIDZKJ+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 29
      LastChar: 31
      FontDescriptor: 
       FontName: CIDZKJ+STIXGeneral-Regular
       Flags: Serif, Symbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ZVNHZP+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZVNHZP+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: VNJEVX+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: VNJEVX+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41598-020-58696-y</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, doi:10.1038/s41598-020-58696-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Concepcion Casado</rdf:li>
               <rdf:li>Cristina Galvez</rdf:li>
               <rdf:li>Maria Pernas</rdf:li>
               <rdf:li>Laura Tarancon-Diez</rdf:li>
               <rdf:li>Carmen Rodriguez</rdf:li>
               <rdf:li>Vamp#x000ED;ctor Sanchez-Merino</rdf:li>
               <rdf:li>Mar Vera</rdf:li>
               <rdf:li>Isabel Olivares</rdf:li>
               <rdf:li>Rebeca De Pablo-Bernal</rdf:li>
               <rdf:li>Alberto Merino-Mansilla</rdf:li>
               <rdf:li>Jorge Del Romero</rdf:li>
               <rdf:li>Ramon Lorenzo-Redondo</rdf:li>
               <rdf:li>Ezequiel Ruiz-Mateos</rdf:li>
               <rdf:li>Maramp#x000ED;a Salgado</rdf:li>
               <rdf:li>Javier Martinez-Picado</rdf:li>
               <rdf:li>Cecilio Lopez-Galindez</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41598-020-58696-y</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41598-020-58696-y</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2020, The Author(s)</prism:copyright>
         <prism:issn>2045-2322</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41598-020-58696-y</pdfx:doi>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2020-01-30T16:34:45+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2020-01-29T11:15:55+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2020-01-30T16:34:45+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:89f4b834-d0af-42a2-945a-8fc948878eaf</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:c69af50b-6887-46e7-b8ee-69202248a2cc</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:c16ba394-6cb4-49f2-9d0e-8f8cca0fb957</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-01-29T11:16:38+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 449, 245, 452, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 454, 245, 457, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 498, 235, 500, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 522, 215, 525, 203
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 526, 215, 529, 203
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 379, 195, 382, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 281, 53, 360, 43
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 364, 53, 420, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 549, 694, 552, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 457, 684, 460, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 461, 684, 464, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 513, 674, 519, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 506, 664, 512, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 513, 664, 519, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 246, 545, 249, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 459, 426, 464, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 546, 355, 552, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 411, 335, 551, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 331, 275, 334, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 335, 275, 341, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 494, 234, 500, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 364, 175, 369, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 282, 155, 287, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 546, 155, 552, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 368, 145, 554, 133
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 135, 191, 123
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 158, 64, 224, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 361, 54, 367, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 368, 54, 374, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 734, 334, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 266, 634, 272, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 273, 634, 279, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 449, 603, 454, 591
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 466, 583, 471, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 321, 473, 327, 461
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 384, 393, 389, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 549, 364, 554, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 438, 354, 517, 342
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 284, 403, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 436, 284, 457, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 365, 264, 370, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 217, 214, 220, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 214, 227, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 288, 204, 293, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 193, 194, 199, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 535, 194, 539, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 542, 194, 545, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 546, 194, 552, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 480, 164, 485, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 249, 134, 260, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 391, 74, 400, 62
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 397, 54, 406, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 437, 298, 425
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 406, 405, 412, 393
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 542, 345, 547, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 549, 345, 554, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 296, 315, 302, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 479, 315, 484, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 245, 425, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 427, 245, 432, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 333, 185, 344, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 523, 135, 533, 123
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 249, 105, 259, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 252, 509, 257, 497
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 457, 347, 468, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 245, 297, 255, 285
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 446, 287, 451, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 210, 243, 229, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 460, 223, 479, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 506, 159, 516, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 354, 139, 371, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 320, 119, 326, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 285, 85, 304, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 346, 390, 352, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 173, 317, 182, 305
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 526, 225, 531, 213
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 249, 205, 255, 193
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 256, 205, 261, 193
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 426, 175, 431, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 283, 155, 289, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 412, 125, 434, 113
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 248, 105, 253, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 255, 105, 260, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 262, 105, 267, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 486, 95, 491, 83
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 364, 75, 369, 63
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 469, 55, 474, 43
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 331, 492, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 490, 321, 496, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 517, 321, 527, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 462, 281, 468, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 281, 271, 287, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 402, 261, 407, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 408, 261, 414, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 297, 251, 303, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 184, 231, 190, 219
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 352, 201, 358, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 476, 171, 478, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 480, 171, 483, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 235, 151, 245, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 141, 378, 129
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 265, 111, 271, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 492, 91, 512, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 336, 81, 341, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 342, 81, 348, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 435, 71, 441, 59
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 172, 734, 178, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 179, 734, 185, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 418, 724, 424, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 426, 724, 431, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 326, 704, 332, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 236, 674, 241, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 235, 564, 240, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 501, 554, 507, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 237, 514, 243, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 203, 376, 312, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 333, 296, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 316, 290, 306
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 446, 308, 554, 298
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 299, 188, 289
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 203, 282, 349, 272
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 248, 554, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 240, 245, 230
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 408, 223, 514, 213
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 299, 189, 402, 179
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 172, 532, 162
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 138, 318, 128
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 214, 70, 325, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 53, 515, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 717, 310, 707
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 203, 700, 311, 690
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 692, 554, 682
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 683, 271, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 203, 641, 312, 631
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 199, 607, 334, 597
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 582, 554, 571
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 573, 227, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 259, 556, 359, 546
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 532, 548, 554, 537
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 539, 249, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 210, 488, 330, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 480, 554, 469
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 471, 232, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 412, 554, 401
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 403, 271, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 386, 413, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 360, 352, 483, 342
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 335, 433, 325
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 315, 318, 422, 308
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 423, 301, 531, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 267, 505, 257
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 250, 458, 240
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 514, 233, 554, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 224, 281, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 259, 208, 391, 197
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 361, 556, 519, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 349, 527, 441, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 418, 504, 406
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: facbc110
   Type: CRC32
  Checksum: c759619f687d6ff12fa1a083ad3b922d
   Type: MD5
  Checksum: 61255d689e7ffb4f89a0fbcd17d42dae7f56aa11
   Type: SHA-1