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Title: Study design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Genome-wide association Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Classical HLA alleles and amino acid polymorphisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: PLA2R1 locus and its genetic interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Novel loci encoding NFKB1 and IRF4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: SNP-based heritability and risk explained by GWAS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Clinical correlations of the GRS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Potential diagnostic implications of the GRS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Study design overview Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Primary association analyses and genome-wide meta-analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Conditional analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Credible set analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: HLA imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Statistical framework for HLA association testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Analysis of polymorphic amino-acid sites in HLA genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Testing for pairwise epistasis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Functional annotations of GWAS loci Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Pleiotropy analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Podocyte gene annotations of GWAS loci Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: GR analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: CRS formulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: European GWAS validation cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: NEPTUNE GRS validation cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: PLA2R antibody testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Testing for phenotypic correlations of the GRS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: SNP-based heritability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Additional 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864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HMKMGN+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HMKMGN+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HMJONI+AdvOT9bd21c25.I FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: HMJONI+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-020-15383-w The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis Jingyuan Xie Lili Liu Nikol Mladkova Yifu Li Hong Ren Weiming Wang Zhao Cui Li Lin Xiaofan Hu Xialian Yu Jing Xu Gang Liu Yasar Caliskan Carlo Sidore Olivia Balderes Raphael J. Rosen Monica Bodria Francesca Zanoni Jun Y. Zhang Priya Krithivasan Karla Mehl Maddalena Marasa Atlas Khan Fatih Ozay Pietro A. Canetta Andrew S. Bomback Gerald B. Appel Simone Sanna-Cherchi Matthew G. Sampson Laura H. Mariani Agnieszka Perkowska-Ptasinska Magdalena Durlik Krzysztof Mucha Barbara Moszczuk Bartosz Foroncewicz Leszek Pączek Ireneusz Habura Elisabet Ars Jose Ballarin Laila-Yasmin Mani Bruno Vogt Savas Ozturk Abdülmecit Yildiz Nurhan Seyahi Hakki Arikan Mehmet Koc Taner Basturk Gonca Karahan Sebahat Usta Akgul Mehmet Sukru Sever Dan Zhang Domenico Santoro Mario Bonomini Francesco Londrino Loreto Gesualdo Jana Reiterova Vladimir Tesar Claudia Izzi Silvana Savoldi Donatella Spotti Carmelita Marcantoni Piergiorgio Messa Marco Galliani Dario Roccatello Simona Granata Gianluigi Zaza Francesca Lugani GianMarco Ghiggeri Isabella Pisani Landino Allegri Ben Sprangers Jin-Ho Park BeLong Cho Yon Su Kim Dong Ki Kim Hitoshi Suzuki Antonio Amoroso Daniel C. Cattran Fernando C. Fervenza Antonello Pani Patrick Hamilton Shelly Harris Sanjana Gupta Chris Cheshire Stephanie Dufek Naomi Issler Ruth J. Pepper John Connolly Stephen Powis Detlef Bockenhauer Horia C. Stanescu Neil Ashman Ruth J. F. Loos Eimear E. Kenny Matthias Wuttke Kai-Uwe Eckardt Anna Köttgen Julia M. Hofstra Marieke J. H. Coenen Lambertus A. Kiemeney Shreeram Akilesh Matthias Kretzler Lawrence H. Beck Benedicte Stengel Hanna Debiec Pierre Ronco Jack F. M. Wetzels Magdalena Zoledziewska Francesco Cucca Iuliana Ionita-Laza Hajeong Lee Elion Hoxha Rolf A. K. Stahl Paul Brenchley Francesco Scolari Ming-hui Zhao Ali G. Gharavi Robert Kleta Nan Chen Krzysztof Kiryluk Springer US Nature Communications, doi:10.1038/s41467-020-15383-w 10.1038/s41467-020-15383-w http://dx.doi.org/10.1038/s41467-020-15383-w journal Nature Communications © 2020, The Author(s) 2041-1723 10.1038/s41467-020-15383-w springer.com springerlink.com 2010-04-23 True 10.1038/s41467-020-15383-w springer.com springerlink.com Springer 2020-03-24T10:54:47+01:00 2020-03-21T21:48:28+05:30 2020-03-24T10:54:47+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:6dd18e86-1ad8-4be8-89fb-2a3c6cf22a35 uuid:c54f0feb-57cc-4eee-acaa-e973c34931de default 1 converted uuid:f068f635-ef6a-4dd8-9b55-880a6e200789 converted to PDF/A-2b pdfToolbox 2020-03-21T21:49:47+05:30 2 B Lili Liu http://orcid.org/0000-0002-2622-9669 Jun Y. Zhang http://orcid.org/0000-0003-4996-8699 Maddalena Marasa http://orcid.org/0000-0003-0712-2329 Fatih Ozay http://orcid.org/0000-0002-1383-7892 Pietro A. 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Gharavi http://orcid.org/0000-0003-2801-233X Robert Kleta http://orcid.org/0000-0002-0228-8656 Krzysztof Kiryluk http://orcid.org/0000-0002-5047-6715 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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