e38f7f3127d80a91276178bd4e289a35 252645.pdf 8dfcfe7375c3877a70f99d5a113af41a211be1c8 252645.pdf beba97a7f6a6cb003b302859e32f7bc7f1681a8fb07b476d3f8c647af432cdaa 252645.pdf Title: The Circulating Fatty Acid Transporter Soluble CD36 Is Not Associated with Carotid Atherosclerosis in Subjects with Type 1 and Type 2 Diabetes Mellitus Subject: This study aimed to determine the association of fatty acid transporter plasma soluble cluster of differentiation 36 (sCD36) with subclinical carotid atherosclerosis (SCA). A cross-sectional study was conducted in 1023 subjects, 225 with type 1 diabetes (T1D), 276 with type 2 diabetes (T2D) and 522 who were nondiabetic. Carotid atherosclerotic plaque (CAP) presence was determined using B-mode carotid ultrasound imaging. sCD36 were analysed by ELISA, and CD36 surface receptor and mRNA expression were measured by flow cytometry and real-time PCR. Logistic regression models were used to evaluate sCD36 as a biomarker of SCA. Up to 376 (36.75%) participants had at least one CAP, 76 T1D, 164 T2D and 136 without diabetes, while the remaining 647 (63.25%) did not have any CAP. There were no differences in sCD36 between patients with and without CAP in T1D (p = 0.287) or T2D (p = 0.513). Although nondiabetic subjects with plaques had lower sCD36 levels than those without (p = 0.023), the multivariate models revealed no association of sCD36 with CAP in any of the three study groups. No differences were found in surface CD36 or CD36 mRNA expression between the patients with and without CAP. sCD36 is not associated with SCA in type 1 or type 2 diabetic or in nondiabetic subjects. Keywords: atherosclerotic plaque; carotid atherosclerosis; sCD36; type 1 diabetes mellitus; type 2 diabetes mellitus Author: Esmeralda Castelblanco, Lucía Sanjurjo, Maria Barranco-Altirriba, Mireia Falguera, Marta Hernández, Berta Soldevila, Maria-Rosa Sarrias, Josep Franch-Nadal, Juan Antonio Arroyo, José-Manuel Fernandez-Real, Nuria Alonso and Didac Mauricio Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Jun 2 13:33:31 2020 CEST ModDate: Tue Jun 2 13:33:31 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 791204 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VUGUPH+URWPalladioL-Ital Type 1 Custom yes yes no 83 0 KUIMYL+URWPalladioL-Bold Type 1 Custom yes yes no 84 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 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ぅへばづひどねづのぴちぬぜ〴ぜ〰こづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰いづびどでのぜ〴ぜ〰ちのつぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃちひはぴどつぜ〴ぜ〰さぬぴひちびはふのつぜ〴ぜ〰ぉねちでどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰いづぴづひねどのちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰びぃい〳〶ぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: いづびどでのぜ〴ぜ〰ちのつぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃちひはぴどつぜ〴ぜ〰さぬぴひちびはふのつぜ〴ぜ〰ぉねちでどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰いづぴづひねどのちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰びぃい〳〶ぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃちひはぴどつぜ〴ぜ〰さぬぴひちびはふのつぜ〴ぜ〰ぉねちでどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰いづぴづひねどのちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰びぃい〳〶ぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いづぴづひねどのちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰びぃい〳〶ぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃどひっふぬちぴどのでぜ〴ぜ〰こはぬふぢぬづぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぇひはふばびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こはぬふぢぬづぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰きちひにづひぜ〴ぜ〰はてぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぃちひはぴどつぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびてぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぃどひっふぬちぴどのでぜ〴ぜ〰こはぬふぢぬづぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぇひはふばびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こはぬふぢぬづぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰きちひにづひぜ〴ぜ〰はてぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぃちひはぴどつぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびてぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: こはぬふぢぬづぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰きちひにづひぜ〴ぜ〰はてぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぃちひはぴどつぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびてぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: うぬはぷ〭ぃべぴはねづぴひどっぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぃい〳〶ぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: 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