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Title:          Growth Differentiation Factor 15 is a potential biomarker of therapeutic response for TK2 deficient myopathy
Subject:        Scientific Reports, doi:10.1038/s41598-020-66940-8
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Author:         Cristina Dominguez-Gonzalez
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     Item: 
      Title: Growth Differentiation Factor 15 is a potential biomarker of therapeutic response for TK2 deficient myopathy
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patients. 
         Item: 
          Title: Change of serum GDF-15 and FGF-21 over time in treated patients. 
         Item: 
          Title: Change of serum GDF-15 over time in patients that stopped treatment. 
         Item: 
          Title: Clinical outcome measures and correlation analysis. 
         Item: 
          Title: Inflammatory cytokines profile in patients with TK2 deficiency. 
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Study design. 
         Item: 
          Title: Standard protocol approvals, registrations, and patient consents. 
         Item: 
          Title: Study population and setting. 
         Item: 
          Title: Oral administration of deoxynucleosides. 
         Item: 
          Title: Analytical methods. 
         Item: 
          Title: Outcome measures. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Pre-treatment GDF-15 and FGF-21 serum levels are associated with disease severity.
       Item: 
        Title: Figure 2 GDF-15 levels decreased during treatment with deoxynucleosides.
       Item: 
        Title: Figure 3 GDF-15 levels do not decrease over time in the absence of treatment.
       Item: 
        Title: Figure 4 GDF-15 decrease was accompanied by improvement of several clinical outcome measures in treated patients.
       Item: 
        Title: Table 1 Clinical, biochemical and molecular characteristics of patients, before treatment.
       Item: 
        Title: Table 2 Outcome measures, Group 1 (age at treatment initiation <16 years).
       Item: 
        Title: Table 3 Outcome measures, Group 2 (age at treatment initiation >16 years).
       Item: 
        Title: Table 4 Summary of descriptive statistics.
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      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:27946b25-290d-43d9-86fb-4727d89aaf1f</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:032feaad-b3a7-4d74-b073-f6fb543abf5a</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:fb6518e9-1bef-470d-9def-a48b98082950</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-06-13T15:34:34+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>Iptc4xmpExt</pdfaSchema:prefix>
                  <pdfaSchema:schema>IPTC Extension</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>A set of metadata about artwork or an object in the item.</pdfaProperty:description>
                           <pdfaProperty:name>ArtworkOrObject</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ArtworkOrObjectDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The location the content of the item was created.</pdfaProperty:description>
                           <pdfaProperty:name>LocationCreated</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag LocationDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>A location the content of the item is about. For photos that is a location shown in the image.</pdfaProperty:description>
                           <pdfaProperty:name>LocationShown</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag LocationDetails</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Both a Registry Item Id and a Registry Organisation Id to record any registration of this item with a registry.</pdfaProperty:description>
                           <pdfaProperty:name>RegistryId</pdfaProperty:name>
                           <pdfaProperty:valueType>RegistryEntryDetails</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for details about artwork or an object in an image</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>ArtworkOrObjectDetails</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for details of a location</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>LocationDetails</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structured datatype for an entry in a registry, includes the id issued by the registry and the registry's id.</pdfaType:description>
                           <pdfaType:namespaceURI>http://iptc.org/std/Iptc4xmpExt/2008-02-29/</pdfaType:namespaceURI>
                           <pdfaType:prefix>Iptc4xmpExt</pdfaType:prefix>
                           <pdfaType:type>RegistryEntryDetails</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>plus</pdfaSchema:prefix>
                  <pdfaSchema:schema>PLUS LDF Version 1.2.0</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Owner or owners of the copyright in the licensed image.</pdfaProperty:description>
                           <pdfaProperty:name>CopyrightOwner</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq CopyrightOwnerDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Creator/s of the image.</pdfaProperty:description>
                           <pdfaProperty:name>ImageCreator</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq ImageCreatorDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Party providing the image to the Licensor or to the Licensee on behalf of the Licensor.</pdfaProperty:description>
                           <pdfaProperty:name>ImageSupplier</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq ImageSupplierDetail</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Party or parties granting the license to the Licensee.</pdfaProperty:description>
                           <pdfaProperty:name>Licensor</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq LicensorDetail</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>CopyrightOwnerDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>ImageCreatorDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>ImageSupplierDetail</pdfaType:type>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>&lt;DESCRIPTION&gt;</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.useplus.org/ldf/xmp/1.0/</pdfaType:namespaceURI>
                           <pdfaType:prefix>plus</pdfaType:prefix>
                           <pdfaType:type>LicensorDetail</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
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       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
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       Subtype: Link
       Rect: 288, 54, 362, 42
       Flags: Print
       AppearanceDictionary: true
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       Subtype: Link
       Rect: 481, 655, 556, 637
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
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       Subtype: Link
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       Flags: Print
       AppearanceDictionary: true
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       Subtype: Link
       Rect: 177, 714, 179, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
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       Subtype: Link
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       Flags: Print
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       Flags: Print
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       Subtype: Link
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       Flags: Print
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       Subtype: Link
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       Flags: Print
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       Subtype: Link
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       Flags: Print
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       Subtype: Link
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       Flags: Print
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