91c0d3bd0aeab32933dd075172b008b7 antibiotics-09-00439.pdf 0ca370225223966239e2c51bd2e6b43e098a7058 antibiotics-09-00439.pdf 397ce30674edfb6c9593c6b898db04214d91a1c6e6c52829d2765642e5a689a4 antibiotics-09-00439.pdf Title: Prescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda: A Pilot Study to Assess Guideline Concordance Subject: Background: In Uganda, national tuberculosis (TB) treatment guidelines were revised to include the newer generation fluoroquinolones among the second-line treatment options for multidrug-resistant TB. This study was designed to analyze if the prescription of these quinolones is compliant with country recommendations. Methods: This was an observational retrospective study of consumption data for 2017 and 2018 across four selected regional referral hospitals. The sources of consumption data were hospital pharmacy stock cards and the dispensing register. The medical files of patients who had been prescribed fluoroquinolones were also assessed to study compliance with the Uganda Clinical Guidelines and the British National Formulary (BNF). Results: None of the 371 levofloxacin prescriptions analyzed complied with the Uganda Clinical Guidelines, although 250 (67.3%) were prescribed for indications included in the BNF. According to WHO prescription indicators, only 220 (59.3%) prescriptions were appropriate. Conclusion: The prescription of levofloxacin and moxifloxacin increased in the hospitals studied, but in a high proportion of cases, they were not compliant with country recommendations. The findings call for the strengthening of national antimicrobial stewardship programs. Keywords: fluoroquinolones; multidrug-resistant tuberculosis; drug utilization study; prescription habits Author: Victoria Nambasa, Helen B. Ndagije, Allan Serwanga, Leonard Manirakiza, Joanitah Atuhaire, Diana Nakitto, Ronald Kiguba and Albert Figueras Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Jul 23 13:03:07 2020 CEST ModDate: Thu Jul 23 13:03:07 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 378611 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NZMYGO+URWPalladioL-Ital Type 1 Custom yes yes no 97 0 MLXZCH+URWPalladioL-Bold Type 1 Custom yes yes no 98 0 DDRJKU+URWPalladioL-Roma Type 1 Custom yes yes no 99 0 LZJWOX+VnURWPalladioL Type 1 Custom yes yes no 100 0 MOHTVO+Rpxr Type 1 Builtin yes yes no 101 0 YYFPCJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 107 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 124 0 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ぃはのびふねばぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰くふぴばちぴどづのぴび〬ぜ〴ぜ〰ぉの〭ぐちぴどづのぴび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ごあぜ〴ぜ〰しちひつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ちぴぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐちぴどづのぴぜ〴ぜ〰がづぶづぬぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁつとづひづのっづぜ〴ぜ〰ぴはぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぇふどつづぬどのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ちぴぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐちぴどづのぴぜ〴ぜ〰がづぶづぬぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁつとづひづのっづぜ〴ぜ〰ぴはぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぇふどつづぬどのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁつとづひづのっづぜ〴ぜ〰ぴはぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぇふどつづぬどのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰こづぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰いづびどでの〯いづびっひどばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃちぬっふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃはのびふねばぴどはのぜ〴ぜ〰げちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: こぴふつべぜ〴ぜ〰こづぴぴどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰いづびどでの〯いづびっひどばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃちぬっふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃはのびふねばぴどはのぜ〴ぜ〰げちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: こぴふつべぜ〴ぜ〰いづびどでの〯いづびっひどばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃちぬっふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃはのびふねばぴどはのぜ〴ぜ〰げちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: こぴふつべぜ〴ぜ〰ざちひどちぢぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぃちぬっふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃはのびふねばぴどはのぜ〴ぜ〰げちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃちぬっふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃはのびふねばぴどはのぜ〴ぜ〰げちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぁばばひはばひどちぴづのづびびぜ〴ぜ〰はてぜ〴ぜ〰さびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⹁⸩‾㸊⠩਼㰠⽓ 䝯呯 䐠⡴慢汥⹣慰瑩潮⸵ Item: Title: Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NZMYGO+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 151 FontDescriptor: FontName: NZMYGO+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MKHHVF+EURB10 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: MKHHVF+EURB10 Flags: Symbolic FontBBox: -30, -247, 1178, 723 FontFile: true Font: BaseFont: MLXZCH+URWPalladioL-Bold FontSubset: true FirstChar: 3 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