98e6c95bb3f9403c34724270acaf3cd8 252822.pdf 786fcc68d9f34552ddfef761d4343b625e3e321b 252822.pdf 3813afdc4cb3b5f5f2f945ab90e720fca47f91b0d70c4b3c0a1b32433b6a94cb 252822.pdf Title: Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo Subject: The intake of olive oil (OO) enriched with phenolic compounds (PCs) promotes ex vivo HDL-mediated macrophage cholesterol efflux in humans. We aimed to determine the effects of PC-enriched virgin OO on reverse cholesterol transport (RevCT) from macrophages to feces in vivo. Female C57BL/6 mice were given intragastric doses of refined OO (ROO) and a functional unrefined virgin OO enriched with its own PC (FVOO) for 14 days. Our experiments included two independent groups of mice that received intragastric doses of the phenolic extract (PE) used to prepare the FVOO and the vehicle solution (saline), as control, for 14 days. FVOO intake led to a significant increase in serum HDL cholesterol and its ability to induce macrophage cholesterol efflux in vitro when compared with ROO group. This was concomitant with the enhanced macrophage-derived [3H]cholesterol transport to feces in vivo. PE intake per se also increased HDL cholesterol levels and significantly promoted in vivo macrophage-to-feces RevCT rate when compared with saline group. PE upregulated the expression of the main macrophage transporter involved in macrophage cholesterol efflux, the ATP binding cassette a1. Our data provide direct evidence of the crucial role of OO PCs in the induction of macrophage-specific RevCT in vivo. Keywords: HDL; reverse cholesterol transport; virgin olive oil; phenolic compounds; mice VOHF project Author: Lídia Cedó, Sara Fernández-Castillejo, Laura Rubió, Jari Metso, David Santos, Daniel Muñoz-Aguayo, Andrea Rivas-Urbina, Mireia Tondo, Karen Alejandra Méndez-Lara, Marta Farràs, Matti Jauhiainen, Maria-José Motilva, Montserrat Fitó, Francisco Blanco-Vaca, Rosa Solà and Joan Carles Escolà-Gil Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Aug 3 08:49:53 2020 CEST ModDate: Mon Aug 3 08:49:53 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1167521 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NIBXQJ+URWPalladioL-Ital Type 1 Custom yes yes no 110 0 OVMWKD+URWPalladioL-Bold Type 1 Custom yes yes no 111 0 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HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰こづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰きどっづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がどばどつぜ〴ぜ〰ちのつぜ〴ぜ〰ぁばはぬどばはばひはぴづどのぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅのぺべねづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶぃごぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Children: Item: Title: きどっづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がどばどつぜ〴ぜ〰ちのつぜ〴ぜ〰ぁばはぬどばはばひはぴづどのぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅのぺべねづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶぃごぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: がどばどつぜ〴ぜ〰ちのつぜ〴ぜ〰ぁばはぬどばはばひはぴづどのぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅのぺべねづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶぃごぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぅのぺべねづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶぃごぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶぃごぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぅへぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰ぃちばちっどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: あどぬづぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぐとづのはぬどっぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰きづぴちぢはぬどぴづびぜ〴ぜ〰いづぴづひねどのちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: けふちのぴどぴちぴどぶづぜ〴ぜ〰げご〭ぐぃげぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄱ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ぉのっひづちびづびぜ〴ぜ〰えいがぜ〴ぜ〰ぃとはぬづびぴづひはぬ〬ぜ〴ぜ〰ぁぐくぁ〱〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎちびっづのぴぜ〴ぜ〰ばひづ〭えいがぜ〴ぜ〰ぐちひぴどっぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶづひびづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ごひちのびばはひぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰えいが〭きづつどちぴづつぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰あふぴぜ〴ぜ〰いはぜ〴ぜ〰ぎはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰がどぶづひぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぁぢっち〱ぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: うざくくぜ〴ぜ〰ぉのっひづちびづびぜ〴ぜ〰えいがぜ〴ぜ〰ぃとはぬづびぴづひはぬ〬ぜ〴ぜ〰ぁぐくぁ〱〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎちびっづのぴぜ〴ぜ〰ばひづ〭えいがぜ〴ぜ〰ぐちひぴどっぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶづひびづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ごひちのびばはひぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰えいが〭きづつどちぴづつぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰あふぴぜ〴ぜ〰いはぜ〴ぜ〰ぎはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰がどぶづひぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぁぢっち〱ぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴびぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭ぴは〭うづっづびぜ〴ぜ〰げづぶづひびづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ごひちのびばはひぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰えいが〭きづつどちぴづつぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰あふぴぜ〴ぜ〰いはぜ〴ぜ〰ぎはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰がどぶづひぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぁぢっち〱ぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: うざくくぜ〴ぜ〰ちのつぜ〴ぜ〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰えいが〭きづつどちぴづつぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぅててぬふへぜ〴ぜ〰あふぴぜ〴ぜ〰いはぜ〴ぜ〰ぎはぴぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰がどぶづひぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴづびぴどのちぬぜ〴ぜ〰ぃとはぬづびぴづひはぬぜ〴ぜ〰ぁぢびはひばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぁぢっち〱ぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くくぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰さばひづでふぬちぴづぜ〴ぜ〰きちっひはばとちでづぜ〴ぜ〰ぁぢっち〱ぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MPUDFL+PazoMath FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: MPUDFL+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: NXQZWG+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: NXQZWG+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: NIBXQJ+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: NIBXQJ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OVMWKD+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 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