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Title:          Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation
Subject:        Experimental Neurology, 323 (2019) 113095. doi:10.1016/j.expneurol.2019.113095
Keywords:       Long-term potentiation; VSNL1; Hippocampus; Memory; Development; Dendritic spines; 
Author:         Albert Giralt
Creator:        Elsevier
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      Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation
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        Title: Introduction
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        Title: Materials and methods
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          Title: SHIRPA assessment
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          Title: Visual placing response and light/dark choice test
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          Title: Open field
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          Title: Dark-light paradigm
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          Title: Object recognition test
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          Title: Strategy shifting in a water T-maze
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          Title: T-maze spontaneous alternation (T-SAT)
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          Title: Place and response learning in a T-maze
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          Title: RNA deep sequencing
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          Title: Histopathological analysis
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          Title: Golgi staining and spine counting
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          Title: Electron microscopy
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          Title: DioListic staining and spine counting and morphology analysis
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          Title: Immunohistochemistry and immunofluorescence
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          Title: Confocal imaging
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          Title: Electrophysiology
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          Title: Western blotting
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          Title: Hippocampal primary cultures
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          Title: Construct generation and transfection
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          Title: Experimental design and statistical analysis
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        Title: Results
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          Title: Helios is localized in developing calbindin-positive pyramidal neurons of the CA1
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          Title: Normal neurological state in neonatal He−/− mice
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          Title: Specific spatial learning and memory deficits in adult he−/− mice
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          Title: Specific impairment of synaptic plasticity in the Schaffer collateral pathway but not in the cortico-striatal pathway in adult 䠀攢ሀ⼢ሀ 洀椀挀攩㸾൥湤潢樍ㄱ㤲‰扪഼㰯䑥獴⣾＀洀欀㨀䠀㈀开㈀㠩⽎數琠ㄱ㤱‰⁒⽐慲敮琠ㄱ㘴‰⁒⽐牥瘠ㄱ㤳‰⁒⽔楴汥⣾＀匀瀀攀挀椀昀椀挀 猀瀀愀琀椀愀氀 氀攀愀爀渀椀渀最 愀渀搀 洀攀洀漀爀礀 搀攀昀椀挀椀琀猀 椀渀 愀搀甀氀琀 栀攢ሀ⼢ሀ 洀椀挀攩㸾൥湤潢樍ㄱ㤳‰扪഼㰯䑥獴⣾＀洀欀㨀䠀㈀开㈀㜩⽎數琠ㄱ㤲‰⁒⽐慲敮琠ㄱ㘴‰⁒⽐牥瘠ㄱ㘵‰⁒⽔楴汥⣾＀一漀爀洀愀氀 渀攀甀爀漀氀漀最椀挀愀氀 猀琀愀琀攀 椀渀 渀攀漀渀愀琀愀氀 䠀攢ሀ⼢ሀ 洀椀挀攩㸾൥湤潢樍ㄠ〠潢樍㰼⽁湮潴獛㈠〠删㌠〠删㐠〠删㔠〠删㘠〠删㜠〠删㠠〠删㤠〠删㄰‰⁒‱ㄠ〠删ㄲ‰⁒‱㌠〠删ㄴ‰⁒‱㔠〠删ㄶ‰⁒‱㜠〠删ㄸ‰⁒‱㤠〠删㈰‰⁒′ㄠ〠删㈲‰⁒′㌠〠删㈴‰⁒′㔠〠删㈶‰⁒′㜠〠删㈸‰⁒′㤠〠删㌰‰⁒″ㄠ〠删㌲‰⁒″㌠〠删㌴‰⁒″㔠〠删㌶‰⁒″㜠〠删㌸‰⁒″㤠〠剝⽃潮瑥湴猠㐰‰⁒⽃牯灂潸嬰‰‵㤵⸲㜶‷㤳⸷〱崯䵥摩慂潸嬰‰‵㤵⸲㜶‷㤳⸷〱崯偡牥湴‱〱ㄠ〠刯光湳敲瑥搠瑲略⽒敳潵牣敳㰼⽃潬潲印慣攼㰯䍓〠ㄱ〰‰⁒㸾⽅硴䝓瑡瑥㰼⽇匰‱㄰ㄠ〠刯䝓ㄠㄱ㈶‰⁒㸾⽆潮琼㰯䌰弰‵ㄲ‰⁒⽃たㄠㄱ㈳‰⁒⽔ㅟ〠㄰㤷‰⁒⽔ㅟㄠㄱㄴ‰⁒⽔ㅟ㈠㔰㜠〠刯吱弳‵〳‰⁒⽔ㅟ㐠ㄱ〵‰⁒⽔ㅟ㔠ㄱ㈰‰⁒㸾⽐牯捓整嬯偄䘯呥硴崾㸯副瑡瑥‰⽔祰支偡来㸾൥湤潢樍㈠〠潢樍㰼⽂潲摥牛〠〠そ⽄敳琨bb0125
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         Item: 
          Title: Helios deficiency induces specific dendritic spine density and morphology alterations in calbindin-positive CA1 pyramidal neur漀渀猩㸾൥湤潢樍ㄱ㤱‰扪഼㰯䑥獴⣾＀洀欀㨀䠀㈀开㈀㤩⽎數琠ㄱ㤰‰⁒⽐慲敮琠ㄱ㘴‰⁒⽐牥瘠ㄱ㤲‰⁒⽔楴汥⣾＀匀瀀攀挀椀昀椀挀 椀洀瀀愀椀爀洀攀渀琀 漀昀 猀礀渀愀瀀琀椀挀 瀀氀愀猀琀椀挀椀琀礀 椀渀 琀栀攀 匀挀栀愀昀昀攀爀 挀漀氀氀愀琀攀爀愀氀 瀀愀琀栀眀愀礀 戀甀琀 渀漀琀 椀渀 琀栀攀 挀漀爀琀椀挀漀ⴀ猀琀爀椀愀琀愀氀 瀀愀琀栀眀愀礀 椀渀 愀搀甀氀琀He−/− mice
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          Title: Identification of VSNL1 as a core gene to mediate hippocampal maturation deficits in Helios deficient mice
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        Title: Discussion
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        Title: Ethics approval
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        Title: mk:H1_36
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        Title: Acknowledgements
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        Title: Supplementary data
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        Title: References
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    Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation
    Author: Albert Giralt
    Subject: Experimental Neurology, 323 (2019) 113095. doi:10.1016/j.expneurol.2019.113095
    Keywords: Long-term potentiation; VSNL1; Hippocampus; Memory; Development; Dendritic spines; 
    Creator: Elsevier
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      Annotation: 
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      Annotation: 
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      Annotation: 
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  Checksum: 27258827
   Type: CRC32
  Checksum: 029bc1f8eccd7cd8b8553699d1a7d306
   Type: MD5
  Checksum: 3d2e2302ab1555ad8feadeb13cc77cbdf938a0b2
   Type: SHA-1