7f9f2a76159a5658563645801c86f69a 276013.pdf 1bcd186bfca3db1b30385a2b5107eb66a622f8a4 276013.pdf 2aa4b089febf054bd5d6d14e59b8e9e4636577469861a45e84ad124687d7a0d1 276013.pdf Title: Long-term safety data from the cladribine tablets clinical development program in multiple sclerosis Subject: Multiple Sclerosis and Related Disorders, 46 (2020) 102572. doi:10.1016/j.msard.2020.102572 Keywords: Cladribine tablets; Multiple sclerosis;, Safety; Long-term; Author: T. Leist Creator: Elsevier CreationDate: Tue Dec 1 07:20:44 2020 CET ModDate: Tue Dec 1 07:20:44 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 937828 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- APSUBX+CharisSIL CID Type 0C Identity-H yes yes yes 500 0 EITCUT+Calibri CID TrueType Identity-H yes yes yes 494 0 JKQDTF+CharisSIL Type 1C Custom yes yes yes 481 0 OOAZVP+UniversLTStd Type 1C Custom yes yes yes 482 0 UWMZUS+STIXGeneral-Regular Type 1C Custom yes yes yes 483 0 FSAFGY+CharisSIL-Italic Type 1C Custom yes yes yes 489 0 KMVCLD+CharisSIL-Italic CID Type 0C Identity-H yes yes yes 40 0 UHMJJG+CharisSIL-Bold Type 1C Custom yes yes yes 35 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-01 02:44:21 CEST RepresentationInformation: 276013.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-29 12:00:24 CEST Size: 937828 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 563 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Long-term safety data from the cladribine tablets clinical development program in multiple sclerosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2 Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: 2.1 Patients   monotherapy oral cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.2 Analysis of adverse events and serious adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.3 Serious adverse events of special interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 3.1 Patient characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3.2 Serious TEAEs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3.3 Serious adverse events of special interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 3.3.1 Lymphopenia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3.3.2 Infections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 3.3.3 Malignancy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 3.3.4 Skin and subcutaneous tissue disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Author statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Info: Title: Long-term safety data from the cladribine tablets clinical development program in multiple sclerosis Author: T. Leist Subject: Multiple Sclerosis and Related Disorders, 46 (2020) 102572. doi:10.1016/j.msard.2020.102572 Keywords: Cladribine tablets; Multiple sclerosis;, Safety; Long-term; Creator: Elsevier CreationDate: Tue Dec 01 07:20:44 CET 2020 ModDate: Tue Dec 01 07:20:44 CET 2020 ID: 0x69bb7124ab234b92e6620d9c90ad3b8a, 0x8c10e582729078459c9c6d45a14302bf Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 247 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: APSUBX+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: KMVCLD+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: EITCUT+Calibri Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: JKQDTF+CharisSIL FontSubset: true FirstChar: 1 LastChar: 95 FontDescriptor: FontName: JKQDTF+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OOAZVP+UniversLTStd FontSubset: true FirstChar: 1 LastChar: 23 FontDescriptor: FontName: OOAZVP+UniversLTStd Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UWMZUS+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: UWMZUS+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UHMJJG+CharisSIL-Bold FontSubset: true FirstChar: 1 LastChar: 38 FontDescriptor: FontName: UHMJJG+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FSAFGY+CharisSIL-Italic FontSubset: true FirstChar: 1 LastChar: 62 FontDescriptor: FontName: FSAFGY+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType0: Font: BaseFont: APSUBX+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: APSUBX+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true Font: BaseFont: KMVCLD+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KMVCLD+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true CIDFontType2: Font: BaseFont: EITCUT+Calibri CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: EITCUT+Calibri Flags: Nonsymbolic FontBBox: -476, -194, 1214, 952 FontFile2: true XMP: application/pdf doi:10.1016/j.msard.2020.102572 Long-term safety data from the cladribine tablets clinical development program in multiple sclerosis T. Leist S. Cook G. Comi X. Montalban G. Giovannoni A. Nolting D. Damian S. Syed A. Galazka Cladribine tablets Multiple sclerosis;, Safety Long-term Elsevier B.V. Multiple Sclerosis and Related Disorders, 46 (2020) 102572. doi:10.1016/j.msard.2020.102572 journal Multiple Sclerosis and Related Disorders © 2020 The Authors. 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