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Title:          In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
Subject:        Scientific Reports, doi:10.1038/s41598-020-64145-7
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Table 1. Description of the bacterial strains, plasmids and primers used in this study. Abbreviations: ST; multilocus sequence type.:104' cannot be found
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      Title: In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug r ...
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Identification of endolysins ElyA1 and ElyA2. 
         Item: 
          Title: Characterization of endolysin muralytic activity. 
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          Title: Combined activity of endolysin ElyA1 and colistin in in vitro assays. 
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        Title: Discussion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Strains and culture conditions. 
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          Title: Identification and purification of endolysins ElyA1 and ElyA2. 
         Item: 
          Title: Determination of the muralytic activity of endolysins ElyA1 and ElyA2. 
         Item: 
          Title: Antibacterial assays. 
         Item: 
          Title: Broth microdilution checkerboard assay and microdilution test to determine minimum inhibitory concentrations (MICs). 
         Item: 
          Title: Time kill curve assay. 
         Item: 
          Title: Galleria mellonella infection model. 
         Item: 
          Title: Mouse skin infection model. 
         Item: 
          Title: Mouse lung infection model. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Genome of the bacteriophages Ab105Φ1 (GenBank: KT588074.
       Item: 
        Title: Figure 2 Characterization of enzymatic activity: (a) Muralytic activity of ElyA1 was determined by spotting ElyA1 and endolysin buffer as a negative control in an overlay of two Gram-negative Acinetobacter baumannii clinical isolates, MAR001 and PAU002 (b
       Item: 
        Title: Figure 3 Specific activity of endolysin ElyA1 tested in clinical isolates from different mutlilocus sequence types (STs) of three Gram-negative members of the ESKAPE group: Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae.
       Item: 
        Title: Figure 4 In vitro bactericidal activity of colistin in combination with endolysin ElyA1 measured by MIC and time kill curves in Acinetobacter baumannii strains GMA001 (a) and PON001 (b) Pseudomonas aeruginosa strains AUS531 (c) and AUS601 (d) Klebsiella p
       Item: 
        Title: Figure 5 In vivo bactericidal activity of colistin in combination with endolysins ElyA1 and ElyA2.
       Item: 
        Title: Table 1 Description of the bacterial strains, plasmids and primers used in this study.
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                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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               </rdf:li>
               <rdf:li rdf:parseType="Resource">
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                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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                  </pdfaSchema:property>
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