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Bittner MD MSPH Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 31th December 2019 ModDate: Tue Dec 31 07:07:35 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 576 x 773.972 pts Page rot: 0 File size: 663991 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BACGLJ+AdvOT61751f86 Type 1C WinAnsi yes yes no 779 0 BACGMJ+AdvPSSym Type 1C WinAnsi yes yes no 781 0 BACGHP+AdvOT5b669f61 Type 1C WinAnsi yes yes no 742 0 BACGIP+AdvOTa2a4c9ce Type 1C WinAnsi yes yes no 744 0 BACGJA+AdvOTe81213fa Type 1C WinAnsi yes yes no 747 0 BACGJB+AdvOT2986fa51 Type 1C WinAnsi yes yes no 752 0 BACGJC+AdvOT2986fa51+fb Type 1C Custom yes yes yes 756 0 BACGJD+AdvP4C4E74 Type 1C Custom yes yes yes 762 0 BACGJE+AdvOT2986fa51+20 Type 1C WinAnsi yes yes no 764 0 BACGKF+AdvOTe81213fa+20 Type 1C WinAnsi yes yes no 766 0 BACGKG+AdvOTe81213fa+fb Type 1C Custom yes yes yes 770 0 BACGLH+AdvOT8e266094.B Type 1C WinAnsi yes yes no 776 0 BACGLI+AdvOT8e266094.B+20 Type 1C WinAnsi yes yes no 783 0 BACGNK+AdvOT1a97e067.I Type 1C WinAnsi yes yes no 439 0 BACGNL+AdvOT1a97e067.I+20 Type 1C WinAnsi yes yes no 444 0 BACGOL+AdvOTd9ad3ae4.I Type 1C WinAnsi yes yes no 447 0 BACGOM+AdvOT61751f86+20 Type 1C WinAnsi yes yes no 450 0 BACGON+AdvOT78d326c7 Type 1C WinAnsi yes yes no 456 0 BACGPO+AdvOT8817665d Type 1C WinAnsi yes yes no 459 0 BACGPP+AdvOT8f503d4a Type 1C WinAnsi yes yes no 462 0 BACHAA+AdvOTc3f2c111.B Type 1C WinAnsi yes yes no 453 0 BACHAB+AdvOTc3f2c111.B+fb Type 1C Custom yes yes yes 454 0 BACHBC+AdvPS44A44B Type 1C WinAnsi yes yes no 471 0 BACHCC+AdvP4C4E51 Type 1C WinAnsi yes yes no 476 0 BACHED+AdvOTe60b6cd3.B Type 1C WinAnsi yes yes no 481 0 BACHFD+GuardianTextSans-Medium Type 1C Custom yes yes yes 483 0 BACHGE+GuardianTextSans-Bold Type 1C WinAnsi yes yes no 493 0 BACIEA+AdvOTc3f2c111.B+20 Type 1C WinAnsi yes yes no 505 0 BACIGP+AdvOTf2345705 Type 1C WinAnsi yes yes no 511 0 BACIHA+AdvOTf2345705+fb Type 1C Custom yes yes yes 512 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-12 02:23:17 CEST RepresentationInformation: 283349.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-11 11:09:54 CEST Size: 663991 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date Offset: 650736 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib31' cannot be found Offset: 633822 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 841 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Measurement of lipoproteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Baseline characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Baseline lipoprotein(a), cardiovascular events, and mortality in the placebo group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Effect of alirocumab on MACE stratified by baseline lipoprotein(a) quartile Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Effect of alirocumab on lipoprotein(a) levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Effect of alirocumab-induced changes in lipoprotein(a) and LDL-Ccorr on outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Study limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Info: Title: Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome Author: Vera A. 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Bittner MD MSPH Michael Szarek PhD Philip E. Aylward BM BCh PhD Deepak L. Bhatt MD MPH Rafael Diaz MD Jay M. Edelberg MD PhD Zlatko Fras MD Shaun G. Goodman MD Sigrun Halvorsen MD Corinne Hanotin MD Robert A. Harrington MD J. Wouter Jukema MD PhD Virginie Loizeau MS Patrick M. Moriarty MD Angèle Moryusef MD Robert Pordy MD Matthew T. Roe MD MHS Peter Sinnaeve MD Sotirios Tsimikas MD Robert Vogel MD Harvey D. White DSc Doron Zahger MD Andreas M. Zeiher MD Ph. Gabriel Steg MD Gregory G. Schwartz MD PhD ODYSSEY OUTCOMES Committees and Investigators acute coronary syndromes alirocumab low-density lipoprotein cholesterol major adverse cardiovascular events proprotein convertase subtilisin/kexin type 9 inhibition Journal of the American College of Cardiology, 75 (2020) 133-144. doi:10.1016/j.jacc.2019.10.057 Elsevier journal Journal of the American College of Cardiology © 2020 The Authors. 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