4f7c7ba5b4d0bf524c0d55e96ca39737 283361.pdf 8de3a309444710a92b75e66b08b715fc2d31bc36 283361.pdf 064cf053d597bda0b19cf7d86dcf014d62d1ebb75c25f15a04e95ad0212e4ea3 283361.pdf Title: Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17 Subject: Although the advent of combined antiretroviral therapy has substantially improved the survival of HIV-1-infected individuals, non-AIDS-related diseases are becoming increasingly prevalent in HIV-1-infected patients. Persistent abnormalities in coagulation appear to contribute to excess risk for a broad spectrum of non-AIDS defining complications. Alterations in coagulation biology in the context of HIV infection seem to be largely a consequence of a chronically inflammatory microenvironment leading to endothelial cell (EC) dysfunction. A possible direct role of HIV-1 proteins in sustaining EC dysfunction has been postulated but not yet investigated. The HIV-1 matrix protein p17 (p17) is secreted from HIV-1-infected cells and is known to sustain inflammatory processes by activating ECs. The aim of this study was to investigate the possibility that p17-driven stimulation of human ECs is associated with increased production of critical coagulation factors. Here we show the involvement of autophagy in the p17-induced accumulation and secretion of von Willebrand factor (vWF) by ECs. In vivo experiments confirmed the capability of p17 to exert a potent pro-coagulant activity soon after its intravenous administration. Keywords: HIV-1; p17 matrix protein; coagulation; thrombin-antithrombin complex; AIDS-related diseases; autophagy Author: Antonella Bugatti, Stefania Marsico, Pietro Mazzuca, Kai Schulze, Thomas Ebensen, Cinzia Giagulli, Esther Peña, Lina Badimón, Mark Slevin, Arnaldo Caruso, Carlos A. Guzman and Francesca Caccuri Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Mar 16 13:10:28 2020 CET ModDate: Mon Mar 16 13:10:28 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3013679 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FCPYSM+URWPalladioL-Ital Type 1 Custom yes yes no 97 0 IEAIAW+URWPalladioL-Bold Type 1 Custom yes yes no 98 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 99 0 SOZKOC+VnURWPalladioL-Bold Type 1 Custom yes yes no 100 0 TQLOCI+URWPalladioL-Roma Type 1 Custom yes yes no 101 0 XWMAOK+Pxsy Type 1 Builtin yes yes no 102 0 FATHTC+Rpxr Type 1 Builtin yes yes no 103 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 108 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 109 0 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yes yes 431 0 Times New Roman TrueType WinAnsi no no no 432 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 470 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 471 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 472 0 Times New Roman TrueType WinAnsi no no no 473 0 EKJZNB+VnURWPalladioL Type 1 Custom yes yes no 642 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 643 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-12 02:22:45 CEST RepresentationInformation: 283361.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-11 13:44:47 CEST Size: 3013679 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰えぉざ〭〱ぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰ば〱〷ぜ〴ぜ〰ぉのつふっづびぜ〴ぜ〰ぶしうぜ〴ぜ〰ぃべぴはばぬちびねどっぜ〴ぜ〰ぁっっふねふぬちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぅぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁふぴはばとちでべぜ〴ぜ〰ぃはのぴひはぬびぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴ぜ〰さばはのぜ〴ぜ〰ば〱〷ぜ〴ぜ〰こぴどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどびぴどっぜ〴ぜ〰ぉのびどでとぴぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ば〱〷〭ごひどででづひづつぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐ〱〷〭ごひどででづひづつぜ〴ぜ〰ぶしうぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰げづぱふどひづびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐぉ〳かぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ごとづぜ〴ぜ〰えぉざ〭〱ぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰ば〱〷ぜ〴ぜ〰ぉのつふっづびぜ〴ぜ〰ぶしうぜ〴ぜ〰ぃべぴはばぬちびねどっぜ〴ぜ〰ぁっっふねふぬちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぅぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁふぴはばとちでべぜ〴ぜ〰ぃはのぴひはぬびぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴ぜ〰さばはのぜ〴ぜ〰ば〱〷ぜ〴ぜ〰こぴどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどびぴどっぜ〴ぜ〰ぉのびどでとぴぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ば〱〷〭ごひどででづひづつぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐ〱〷〭ごひどででづひづつぜ〴ぜ〰ぶしうぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰げづぱふどひづびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐぉ〳かぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁふぴはばとちでべぜ〴ぜ〰ぃはのぴひはぬびぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴ぜ〰さばはのぜ〴ぜ〰ば〱〷ぜ〴ぜ〰こぴどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどびぴどっぜ〴ぜ〰ぉのびどでとぴぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ば〱〷〭ごひどででづひづつぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐ〱〷〭ごひどででづひづつぜ〴ぜ〰ぶしうぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰げづぱふどひづびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐぉ〳かぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きづっとちのどびぴどっぜ〴ぜ〰ぉのびどでとぴぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ば〱〷〭ごひどででづひづつぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰はてぜ〴ぜ〰ぶしうぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐ〱〷〭ごひどででづひづつぜ〴ぜ〰ぶしうぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰げづぱふどひづびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐぉ〳かぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐ〱〷〭ごひどででづひづつぜ〴ぜ〰ぶしうぜ〴ぜ〰こぴはひちでづぜ〴ぜ〰ちのつぜ〴ぜ〰こづっひづぴどはのぜ〴ぜ〰げづぱふどひづびぜ〴ぜ〰ぁっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐぉ〳かぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごとひはねぢどのぜ〴ぜ〰ぁのぴどぴとひはねぢどのぜ〴ぜ〰ぜ〵ぜ〰ごぁごぜ〵ㅜ〰ぜ〴ぜ〰ぃはねばぬづへぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰しどぬつぜ〴ぜ〰ごべばづぜ〴ぜ〰ちのつぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰いづてどっどづのぴぜ〴ぜ〰きどっづぜ〴ぜ〰ごひづちぴづつぜ〴ぜ〰しどぴとぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰げづっはねぢどのちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰ちのつぜ〴ぜ〰ねぁぢぜ〴ぜ〰ぴはぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰ぶしうぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ぢべぜ〴ぜ〰びどげぎぁぜ〴ぜ〰ごづっとのどぱふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Children: Item: Title: げづっはねぢどのちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰ちのつぜ〴ぜ〰ねぁぢぜ〴ぜ〰ぴはぜ〴ぜ〰ば〱〷ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰ぶしうぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ぢべぜ〴ぜ〰びどげぎぁぜ〴ぜ〰ごづっとのどぱふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰ぶしうぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ぢべぜ〴ぜ〰びどげぎぁぜ〴ぜ〰ごづっとのどぱふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: うぬふはひづびっづのぴぜ〴ぜ〰ぶしうぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ぢべぜ〴ぜ〰びどげぎぁぜ〴ぜ〰ごづっとのどぱふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: こどぬづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぁふぴはばとちでべぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ぢべぜ〴ぜ〰びどげぎぁぜ〴ぜ〰ごづっとのどぱふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: えふねちのぜ〴ぜ〰ぶしうぜ〴ぜ〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きふひどのづぜ〴ぜ〰ごぁごぜ〴ぜ〰ぃはねばぬづへづびぜ〴ぜ〰ぢべぜ〴ぜ〰ぅがぉこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: 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