da01f53bde2d699b26d127e9d337b30f  283564.pdf
01108cef933cbac238308a64af3fffc734d778cd  283564.pdf
ad1d9c05a0cb3fba5c864170c7f0862c0f1ec6c8e1d7ea828db6a3104fc57420  283564.pdf

Title:          Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depressio
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      634.32 x 833.04 pts
Page rot:       0
File size:      1547844 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EBEIII+OpenSans-Semibold             CID TrueType      Identity-H       yes yes yes    522  0
EBEIIH+OpenSans                      CID TrueType      Identity-H       yes yes yes    523  0
LMBODA+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     530  0
LMBOMG+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     531  0
LMBOMH+AdvPSMP13                     Type 1C           WinAnsi          yes yes no     532  0
LMBOMI+AdvOTc20ddc96                 Type 1C           WinAnsi          yes yes no     533  0
LMBPAH+AdvT001                       Type 1C           Custom           yes yes no     534  0
LMBPCH+AdvOT5fcf1b24+20              Type 1C           WinAnsi          yes yes no     535  0
LMBOHA+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no     536  0
LMBOHB+AdvP4C4E59                    Type 1C           Custom           yes yes yes    537  0
LMBOLA+AdvP4C4E74                    Type 1C           Custom           yes yes yes    538  0
LMBOLB+AdvOT5fcf1b24                 Type 1C           WinAnsi          yes yes no     539  0
LMBOLC+AdvOT2bda31c3.B               Type 1C           WinAnsi          yes yes no     540  0
LMBOLD+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     541  0
LMBOME+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     542  0
LMBOMF+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     543  0
LMBPDI+AdvOTd0125be5.BI              Type 1C           WinAnsi          yes yes no     559  0
LMBPJG+HelveticaNeueLTStd-Roman      Type 1C           Custom           yes yes yes    562  0
LMBPJH+HelveticaNeueLTStd-It         Type 1C           WinAnsi          yes yes no     563  0
LMBPJI+AdvOT5c7b8c86.I               Type 1C           WinAnsi          yes yes no     564  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-10-18 02:25:21 CEST
 RepresentationInformation: 283564.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-10-17 11:09:06 CEST
  Size: 1547844
  Format: PDF
  Version: 1.5
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-87
  InfoMessage: File header gives version as 1.5, but catalog dictionary gives version as 1.4
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF3' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF4' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF5' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF7' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF8' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF9' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF10' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF11' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF12' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF13' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF14' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF15' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF6' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0002' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0010' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0017' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0018' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0026' cannot be found
   Offset: 136001
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0028' cannot be found
   Offset: 136001
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 699
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
        Children: 
         Item: 
          Title: Study design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Patient-reported outcomes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: Statistics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: Pruritus
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Pain
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Sleep
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: Patient-reported symptoms of AD
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: Symptoms of anxiety and depression
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: Health-related quality of life
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Global assessment of disease status and treatment effect
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
         Item: 
          Title: Safety
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: Disclosure statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
   Info: 
    Title: Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depressio
   ID: 0xf82b36fb03ae1da1a98b430b0de75f39, 0xf82b36fb03ae1da1a98b430b0de75f39
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im10
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im13
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im14
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im11
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im12
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im17
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im18
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im15
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im16
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 200
      ImageHeight: 283
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Name: Im1
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im3
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3150
      ImageHeight: 746
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im2
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im5
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im4
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im7
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im6
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im9
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im8
   Fonts: 
    Type0: 
     Font: 
      BaseFont: EBEIII+OpenSans-Semibold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EBEIIH+OpenSans
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: LMBPDI+AdvOTd0125be5.BI
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: LMBPDI+AdvOTd0125be5.BI
       Flags: Nonsymbolic
       FontBBox: -95, -250, 930, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBODA+AdvOT46dcae81
      FontSubset: true
      FirstChar: 37
      LastChar: 184
      FontDescriptor: 
       FontName: LMBODA+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -46, -250, 838, 879
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBPJG+HelveticaNeueLTStd-Roman
      FontSubset: true
      FirstChar: 2
      LastChar: 177
      FontDescriptor: 
       FontName: LMBPJG+HelveticaNeueLTStd-Roman
       Flags: Symbolic
       FontBBox: -166, -214, 1076, 952
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LMBOMG+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: LMBOMG+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: -9, -205, 1126, 868
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBPJH+HelveticaNeueLTStd-It
      FontSubset: true
      FirstChar: 112
      LastChar: 112
      FontDescriptor: 
       FontName: LMBPJH+HelveticaNeueLTStd-It
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1106, 957
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOMH+AdvPSMP13
      FontSubset: true
      FirstChar: 97
      LastChar: 97
      FontDescriptor: 
       FontName: LMBOMH+AdvPSMP13
       Flags: Nonsymbolic
       FontBBox: 0, -302, 958, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBPJI+AdvOT5c7b8c86.I
      FontSubset: true
      FirstChar: 58
      LastChar: 112
      FontDescriptor: 
       FontName: LMBPJI+AdvOT5c7b8c86.I
       Flags: Nonsymbolic
       FontBBox: -111, -250, 834, 870
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOMI+AdvOTc20ddc96
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: LMBOMI+AdvOTc20ddc96
       Flags: Nonsymbolic
       FontBBox: -39, -250, 796, 886
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBPAH+AdvT001
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: LMBPAH+AdvT001
       Flags: Symbolic
       FontBBox: -197, -260, 1000, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: LMBPCH+AdvOT5fcf1b24+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: LMBPCH+AdvOT5fcf1b24+20
       Flags: Nonsymbolic
       FontBBox: -128, -205, 1059, 861
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOHA+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: LMBOHA+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -42, -250, 858, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOHB+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 160
      FontDescriptor: 
       FontName: LMBOHB+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LMBOLA+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 188
      FontDescriptor: 
       FontName: LMBOLA+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LMBOLB+AdvOT5fcf1b24
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: LMBOLB+AdvOT5fcf1b24
       Flags: Nonsymbolic
       FontBBox: -40, -250, 777, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOLC+AdvOT2bda31c3.B
      FontSubset: true
      FirstChar: 65
      LastChar: 89
      FontDescriptor: 
       FontName: LMBOLC+AdvOT2bda31c3.B
       Flags: Nonsymbolic
       FontBBox: -44, -250, 892, 905
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOLD+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 58
      LastChar: 118
      FontDescriptor: 
       FontName: LMBOLD+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -39, -250, 875, 897
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOME+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 112
      LastChar: 112
      FontDescriptor: 
       FontName: LMBOME+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -112, -250, 894, 873
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LMBOMF+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: LMBOMF+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: EBEIII+OpenSans-Semibold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBEIII+OpenSans-Semibold
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -583, -282, 1261, 1048
       FontFile2: true
     Font: 
      BaseFont: EBEIIH+OpenSans
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBEIIH+OpenSans
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -549, -270, 1204, 1047
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP toolkit 3.0.1-30, framework 1.6">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
            xmlns:iX="http://ns.adobe.com/iX/1.0/">
      <rdf:Description xmlns:pdf="http://ns.adobe.com/pdf/1.3/" rdf:about="">
         <pdf:Producer>Adobe LiveCycle PDFG ES</pdf:Producer>
         <pdf:Keywords/>
      </rdf:Description>
      <rdf:Description xmlns:photoshop="http://ns.adobe.com/photoshop/1.0/" rdf:about=""/>
      <rdf:Description xmlns:tiff="http://ns.adobe.com/tiff/1.0/" rdf:about=""/>
      <rdf:Description xmlns:xap="http://ns.adobe.com/xap/1.0/" rdf:about="">
         <xap:CreateDate>2020-08-07T21:10:53+05:30</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher</xap:CreatorTool>
         <xap:ModifyDate>2020-08-07T21:10:53+05:30</xap:ModifyDate>
         <xap:MetadataDate>2020-08-07T21:10:53+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/" rdf:about="">
         <xapMM:DocumentID>uuid:8addd02c-2a8d-4824-a074-0375b52bef83</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:9735c38c-787b-4f5b-aca7-e8422204bc96</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" rdf:about="">
         <prism:aggregationType>Journal</prism:aggregationType>
         <prism:publicationName>Journal of Dermatological Treatment</prism:publicationName>
         <prism:copyright>© 2019 The Author(s). Published with license by Taylor &amp; Francis Group, LLC</prism:copyright>
         <prism:issn>0954-6634</prism:issn>
         <prism:eissn>1471-1753</prism:eissn>
         <prism:volume>31</prism:volume>
         <prism:number>6</prism:number>
         <prism:issueName/>
         <prism:coverDate/>
         <prism:pageRange>606-614</prism:pageRange>
         <prism:startingPage>606</prism:startingPage>
         <prism:endingPage>614</prism:endingPage>
         <prism:doi>10.1080/09546634.2019.1612836</prism:doi>
         <prism:url>https://doi.org/10.1080/09546634.2019.1612836</prism:url>
      </rdf:Description>
      <rdf:Description xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1080/09546634.2019.1612836</dc:identifier>
         <dc:language>en-US</dc:language>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Taylor &amp; Francis</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Dermatological Treatment, 2019. doi: 10.1080/09546634.2019.1612836</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Cork Michael J.</rdf:li>
               <rdf:li>Eckert Laurent</rdf:li>
               <rdf:li>Simpson Eric L.</rdf:li>
               <rdf:li>Armstrong April</rdf:li>
               <rdf:li>Barbarot Sébastien</rdf:li>
               <rdf:li>Puig Luis</rdf:li>
               <rdf:li>Girolomoni Giampiero</rdf:li>
               <rdf:li>de Bruin-Weller Marjolein</rdf:li>
               <rdf:li>Wollenberg Andreas</rdf:li>
               <rdf:li>Kataoka Yoko</rdf:li>
               <rdf:li>Remitz Anita</rdf:li>
               <rdf:li>Beissert Stefan</rdf:li>
               <rdf:li>Mastey Vera</rdf:li>
               <rdf:li>Ardeleanu Marius</rdf:li>
               <rdf:li>Chen Zhen</rdf:li>
               <rdf:li>Gadkari Abhijit</rdf:li>
               <rdf:li>Chao Jingdong</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Atopic dermatitis</rdf:li>
               <rdf:li>dupilumab</rdf:li>
               <rdf:li>patient-reported outcomes</rdf:li>
               <rdf:li>quality of life</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description xmlns:jav="http://www.niso.org/schemas/jav/1.0/" rdf:about="">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description xmlns:crossmark="http://crossref.org/crossmark/1.0/" rdf:about="">
         <crossmark:DOI>10.1080/09546634.2019.1612836</crossmark:DOI>
         <crossmark:MajorVersionDate>2019-06-09</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" rdf:about="">
         <pdfx:doi>10.1080/09546634.2019.1612836</pdfx:doi>
         <pdfx:CrossmarkMajorVersionDate>2019-06-09</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>True</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 42, 476, 51
      Annotation: 
       Subtype: Link
       Rect: 365, 688, 516, 696
      Annotation: 
       Subtype: Link
       Rect: 120, 336, 274, 346
      Annotation: 
       Subtype: Link
       Rect: 202, 316, 427, 326
      Annotation: 
       Subtype: Link
       Rect: 106, 217, 124, 226
      Annotation: 
       Subtype: Link
       Rect: 131, 217, 286, 226
      Annotation: 
       Subtype: Link
       Rect: 106, 170, 122, 179
      Annotation: 
       Subtype: Link
       Rect: 131, 174, 230, 183
      Annotation: 
       Subtype: Link
       Rect: 326, 167, 344, 176
      Annotation: 
       Subtype: Link
       Rect: 351, 174, 452, 183
      Annotation: 
       Subtype: Link
       Rect: 106, 128, 124, 137
      Annotation: 
       Subtype: Link
       Rect: 131, 131, 297, 140
    Page: 
     Label: 606
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 109, 603, 113, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 183, 603, 187, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 261, 603, 265, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 342, 603, 346, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 436, 603, 440, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 500, 603, 502, 613
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 140, 591, 145, 601
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 264, 591, 269, 601
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 365, 591, 367, 601
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 433, 591, 435, 601
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 498, 591, 502, 601
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 107, 579, 109, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 169, 579, 175, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 259, 579, 266, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 321, 579, 328, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 400, 579, 406, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 406, 579, 412, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 503, 579, 510, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 510, 579, 515, 589
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 160, 204, 174, 213
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 120, 181, 124, 190
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 126, 181, 131, 190
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 221, 159, 225, 168
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 275, 148, 294, 157
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 70, 126, 75, 135
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 77, 126, 81, 135
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 83, 126, 92, 135
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 44, 103, 53, 112
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 55, 103, 64, 112
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 66, 103, 75, 112
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 77, 103, 86, 112
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 520, 240, 543, 249
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 405, 217, 410, 226
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 412, 217, 421, 226
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 423, 217, 432, 226
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 543, 195, 552, 204
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 554, 195, 563, 204
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 539, 160, 548, 169
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 550, 160, 559, 169
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 493, 103, 502, 112
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 505, 703, 567, 715
      Annotation: 
       Subtype: Link
       Rect: 444, 603, 453, 613
      Annotation: 
       Subtype: Link
       Rect: 506, 603, 516, 613
      Annotation: 
       Subtype: Link
       Rect: 425, 44, 564, 51
      Annotation: 
       Subtype: Link
       Rect: 465, 727, 567, 751
    Page: 
     Label: 607
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 676, 66, 685
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 68, 676, 90, 685
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 222, 538, 232, 547
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 96, 450, 105, 459
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 244, 306, 253, 315
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 255, 306, 264, 315
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 44, 262, 53, 271
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 44, 229, 53, 238
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 55, 229, 64, 238
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 234, 218, 244, 227
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 245, 218, 255, 227
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 184, 195, 193, 205
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 195, 195, 204, 205
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 44, 162, 53, 171
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 55, 162, 64, 171
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 172, 118, 181, 127
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 44, 52, 53, 61
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 536, 720, 545, 729
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 448, 698, 456, 707
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 396, 676, 405, 685
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 503, 587, 511, 596
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 409, 389, 419, 398
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 400, 284, 428, 293
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 426, 196, 456, 205
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 466, 118, 493, 127
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 498, 118, 528, 127
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 335, 52, 366, 61
       Destination: 12
    Page: 
     Label: 608
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 188, 136, 197
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 159, 154, 187, 163
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 44, 97, 72, 106
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 487, 177, 516, 186
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 334, 41, 362, 50
       Destination: 12
    Page: 
     Label: 609
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 129, 108, 138
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 442, 162, 471, 171
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 525, 127, 557, 136
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 470, 41, 498, 50
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 105, 699, 108, 707
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 690, 375, 698
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 496, 690, 498, 698
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 374, 681, 377, 689
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 497, 681, 500, 689
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 376, 672, 379, 680
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 499, 672, 502, 680
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 130, 663, 133, 671
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 645, 372, 653
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 645, 495, 653
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 370, 636, 371, 644
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 367, 627, 370, 635
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 627, 495, 635
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 609, 372, 617
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 609, 495, 617
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 488, 591, 492, 599
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 371, 582, 374, 590
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 494, 582, 497, 590
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 371, 564, 374, 572
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 494, 564, 497, 572
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 371, 546, 374, 554
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 494, 546, 497, 554
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 371, 528, 374, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 494, 528, 497, 536
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 183, 501, 186, 509
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 373, 510, 376, 518
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 496, 510, 499, 518
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 109, 474, 111, 482
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 373, 492, 376, 500
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 496, 492, 499, 500
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 178, 456, 180, 464
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 376, 465, 379, 473
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 499, 465, 502, 473
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 367, 447, 370, 455
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 493, 447, 495, 455
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 429, 372, 437
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 429, 495, 437
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 367, 402, 370, 410
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 490, 402, 494, 410
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 384, 372, 392
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 384, 495, 392
       Destination: null
    Page: 
     Label: 610
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 232, 198, 260, 207
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 209, 164, 240, 173
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 207, 75, 234, 84
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 429, 226, 461, 235
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 390, 159, 421, 168
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 339, 107, 348, 116
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 453, 96, 462, 105
       Destination: 16
    Page: 
     Label: 611
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 326, 138, 335
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 185, 314, 208, 323
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 210, 314, 219, 323
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 86, 292, 95, 301
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 97, 292, 106, 301
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 108, 292, 117, 301
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 119, 292, 128, 301
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 285, 269, 294, 278
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 44, 246, 53, 255
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 55, 246, 64, 255
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 130, 235, 139, 244
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 285, 178, 294, 187
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 285, 155, 294, 164
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 143, 75, 153, 84
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 358, 372, 367, 381
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 313, 350, 317, 359
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 553, 328, 563, 337
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 377, 251, 387, 260
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 335, 206, 340, 215
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 370, 162, 379, 171
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 377, 41, 386, 50
       Destination: 17
    Page: 
     Label: 612
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 664, 53, 673
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 315, 540, 319, 549
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 484, 319, 493
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 315, 462, 319, 471
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 418, 319, 427
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 373, 319, 382
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 340, 319, 349
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 307, 319, 316
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 274, 319, 283
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 315, 218, 319, 227
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 310, 174, 319, 183
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 310, 130, 319, 139
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 310, 85, 319, 94
       Destination: 9
    Page: 
     Label: 613
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 731, 51, 740
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 709, 51, 718
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 663, 51, 672
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 630, 51, 639
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 596, 51, 605
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 41, 562, 51, 571
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 41, 528, 51, 537
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 483, 51, 492
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 460, 51, 469
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 415, 51, 424
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 381, 51, 390
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 313, 51, 322
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 41, 279, 51, 288
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 41, 245, 51, 254
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 41, 189, 51, 198
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 41, 155, 51, 164
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 41, 87, 51, 95
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 731, 319, 740
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 664, 319, 673
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 620, 319, 629
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 575, 319, 584
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 531, 319, 540
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 486, 319, 495
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 442, 319, 451
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 419, 319, 428
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 386, 319, 395
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 341, 319, 350
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 308, 319, 317
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 310, 275, 319, 284
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 219, 319, 228
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 186, 319, 195
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 163, 319, 172
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 119, 319, 128
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 86, 319, 95
       Destination: 14
    Page: 
     Label: 614
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 731, 51, 740
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 41, 687, 51, 696
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 310, 731, 319, 740
       Destination: 14
  Checksum: b0a791e8
   Type: CRC32
  Checksum: da01f53bde2d699b26d127e9d337b30f
   Type: MD5
  Checksum: 01108cef933cbac238308a64af3fffc734d778cd
   Type: SHA-1