4289d990267136cffeb7ba91902034c8 283570.pdf 2b86cd8287fd47662931b9f98ded48f254287e6f 283570.pdf e1f3a3f615c747652beb2c1264b7e580379e9956eddf79b475f4e86636dae09d 283570.pdf Title: Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain Subject: Scientific Reports, doi:10.1038/s41598-020-59641-9 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Feb 10 18:23:15 2020 CET ModDate: Wed Feb 12 10:07:50 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1060855 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SCBEGO+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 73 0 KPMXYE+Corbel-Bold CID TrueType Identity-H yes yes yes 74 0 EuclidSymbol-Bold Type 1C Custom yes no yes 156 0 OKNCSA+Corbel-Bold2 Type 1C WinAnsi yes yes yes 77 0 ARLXVY+Corbel2 Type 1C WinAnsi yes yes yes 79 0 NBZUOY+Corbel CID TrueType Identity-H yes yes yes 80 0 MyriadPro-It Type 1C WinAnsi yes no yes 81 0 ARLXVY+Corbel2 Type 1C WinAnsi yes yes yes 314 0 EuclidSymbol Type 1C Custom yes no yes 75 0 MinionPro-Regular Type 1C Custom yes no yes 76 0 MinionPro-It Type 1C Custom yes no yes 78 0 MinionPro-Bold Type 1C Custom yes no yes 116 0 YWICHC+STIXGeneral-Regular Type 1C Custom yes yes yes 117 0 STIXGeneral-Italic Type 1C Custom yes no yes 157 0 NQROJY+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 185 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-19 02:27:33 CEST RepresentationInformation: 283570.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-18 11:45:40 CEST Size: 1060855 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_59641.indd: Table 1. Demographic description of the cohort. Description of the main characteristics of the cohort included in this analysis. NIHSS: National institute of Health Stroke Scale; HTN: Hypertension; DM: Diabetes Mellitus; ICH: In:40' cannot be found Offset: 854833 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_59641.indd:Figure 1. Mean dose requirements. Boxplot representing mean dose of acenocoumarol in mg/week (Y-axis) according to the genotype (X-axis) for (A) rs4889490, (B) rs749767, (C) rs1978487, and (D) rs889548.:41' cannot be found Offset: 854833 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_59641.indd: Table 1. Demographic description of the cohort. Description of the main characteristics of the cohort included in this analysis. NIHSS: National institute of Health Stroke Scale; HTN: Hypertension; DM: Diabetes Mellitus; ICH: I:45' cannot be found Offset: 854833 MIMEtype: application/pdf PDFMetadata: Objects: 344 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in ... Children: Item: Title: Results Item: Title: Discussion Item: Title: Methods Children: Item: Title: Study endpoints. Item: Title: Follow-up. Item: Title: Genome-wide association study, and selection of polymorphisms. Item: Title: Statistical analysis. Item: Title: Survival analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Mean dose requirements. Item: Title: Table 1 Demographic description of the cohort. Item: Title: Table 2 Statistically significant polymorphisms associated with maintenance dose. 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