5ea78f891ad522e2e7e2bd36023800f6 283571.pdf ed22ff950ded9997b793e0cc610c7228fb57e7bb 283571.pdf dbb28c1daf66f5f39b073ecdfb655cf9b240f8e041f1362f447525ccdc269780 283571.pdf Title: Usefulness of Clinical Definitions of Influenza for Public Health Surveillance Purposes Subject: This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case definition for ILI in all weeks (aDOR 2.69; 95% CI 2.42–2.99) and epidemic weeks (aDOR 2.20; 95% CI 1.90–2.54). The symptoms that were significant positive predictors for confirmed influenza were fever, cough, myalgia, headache, malaise, and sudden onset. Fever had the highest aDOR in all weeks (4.03; 95% CI 3.38–4.80) and epidemic weeks (2.78; 95% CI 2.21–3.50). All of the case definitions assessed performed better in patients with comorbidities than in those without. The performance of symptoms varied by age groups, with fever being of high value in older people, and cough being of high value in children. In patients with comorbidities, the performance of fever was the highest (aDOR 5.45; 95% CI 3.43–8.66). No differences in the performance of the case definition or symptoms in influenza cases according to virus type were found. Keywords: influenza; sentinel surveillance system; performance assessment; case definition; symptoms; primary healthcare physician Author: Àngela Domínguez, Núria Soldevila, Núria Torner, Ana Martínez, Pere Godoy, Cristina Rius, Mireia Jané and on behalf of the PIDIRAC Sentinel Surveillance Program of Catalonia Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Jan 22 08:44:30 2020 CET ModDate: Wed Jan 22 08:44:30 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 583426 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PJXEOJ+URWPalladioL-Ital Type 1 Custom yes yes no 66 0 RMQLHA+URWPalladioL-Bold Type 1 Custom yes yes no 67 0 MLBXOW+VnURWPalladioL-Bold Type 1 Custom yes yes no 68 0 CUAJJQ+Pxbsy Type 1 Builtin yes yes no 69 0 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