801d6fba48cdc808fe723c5750105bac  283584.pdf
a672cdea123a18c177caf6aeac8d181f92d1c2b8  283584.pdf
a7399916878978cd4558e44cfd3d5506f952997353164325312fc0e143357f6b  283584.pdf

Title:          A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants
Subject:        EBioMedicine, 53 (2020) 102675. doi:10.1016/j.ebiom.2020.102675
Keywords:       Familial pancreatic cancer; Panel sequencing; DNA repair and hereditary cancer genes; Pathogenic variants
Author:         Julie Earl
Creator:        Elsevier
Producer:       Acrobat Distiller 10.1.10 (Windows)
CreationDate:   Fri Mar 20 12:38:59 2020 CET
ModDate:        Fri Mar 20 12:39:17 2020 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      586795 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
FDEFKD+AdvOT5fa4e291+20              Type 1C           WinAnsi          yes yes no     376  0
FDEFKB+AdvOT5fa4e291+fb              Type 1C           Custom           yes yes yes    379  0
FDEFKC+AdvP4C4E74                    Type 1C           Custom           yes yes no     384  0
FDEFDB+AdvOT5fa4e291                 Type 1C           WinAnsi          yes yes no     388  0
FDEFJB+AdvOTf2586c63                 Type 1C           WinAnsi          yes yes no     391  0
FDEMGI+AdvPAC3D                      Type 1C           WinAnsi          yes yes no     394  0
FDEFJA+AdvP4C4E59                    Type 1C           Custom           yes yes yes    397  0
FDEMPF+AdvTTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     229  0
FDEMPG+AdvP4C9543                    Type 1C           Custom           yes yes yes    232  0
FDENAH+AdvOTf2586c63+fb              Type 1C           Custom           yes yes yes     29  0
FDENIG+AdvOT1be73566.B               Type 1C           WinAnsi          yes yes no     237  0
FDENCH+AdvP4C9542                    Type 1C           WinAnsi          yes yes no     240  0
FDEOMO+AdvP4A5FDB                    Type 1C           WinAnsi          yes yes no      81  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-10-20 02:29:08 CEST
 RepresentationInformation: 283584.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-10-19 12:30:46 CEST
  Size: 586795
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 485
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: 2. Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
        Children: 
         Item: 
          Title: 2.1. Recruitment of cases and high risk individuals
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: 2.2. Next generation sequencing of PDAC cases, high risk individuals and non-PDAC cases
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: 2.3. Identification of potentially pathogenic mutations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: 2.4. Validation of pathogenic and likely pathogenic variants
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
         Item: 
          Title: 2.5. Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
        Children: 
         Item: 
          Title: 3.1. Validation of the sequencing panel
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: 3.2. Identification of pathogenic, likely pathogenic variants and potentially pathogenic VUS in PDAC cases
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: 3.3. Potentially pathogenic VUS in cases with other cancer types and high risk individuals
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: 5. Conclusion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: Supplementary materials
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
        Children: 
         Item: 
          Title: References
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
   Info: 
    Title: A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants
    Author: Julie Earl
    Subject: EBioMedicine, 53 (2020) 102675. doi:10.1016/j.ebiom.2020.102675
    Keywords: Familial pancreatic cancer; Panel sequencing; DNA repair and hereditary cancer genes; Pathogenic variants
    Creator: Elsevier
    Producer: Acrobat Distiller 10.1.10 (Windows)
    CreationDate: Fri Mar 20 13:08:59 CET 2020
    ModDate: Fri Mar 20 13:09:17 CET 2020
   ID: 0xf8416262c244db03870af9635a795496, 0xd475fd868b90a488547442fe4e690c98
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 222
      ImageHeight: 299
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: FDEFKC+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FDEFKC+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: FDEFDB+AdvOT5fa4e291
      FontSubset: true
      FirstChar: 37
      LastChar: 248
      FontDescriptor: 
       FontName: FDEFDB+AdvOT5fa4e291
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEMPF+AdvTTb83ee1dd.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: FDEMPF+AdvTTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEFJB+AdvOTf2586c63
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: FDEFJB+AdvOTf2586c63
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEMPG+AdvP4C9543
      FontSubset: true
      FirstChar: 1
      LastChar: 163
      FontDescriptor: 
       FontName: FDEMPG+AdvP4C9543
       Flags: Symbolic
       FontBBox: 0, -947, 1041, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FDEMGI+AdvPAC3D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: FDEMGI+AdvPAC3D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEFJA+AdvP4C4E59
      FontSubset: true
      FirstChar: 2
      LastChar: 160
      FontDescriptor: 
       FontName: FDEFJA+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FDENIG+AdvOT1be73566.B
      FontSubset: true
      FirstChar: 49
      LastChar: 89
      FontDescriptor: 
       FontName: FDENIG+AdvOT1be73566.B
       Flags: Nonsymbolic
       FontBBox: -166, -239, 1114, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDENCH+AdvP4C9542
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: FDENCH+AdvP4C9542
       Flags: Nonsymbolic
       FontBBox: 0, -208, 979, 677
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEOMO+AdvP4A5FDB
      FontSubset: true
      FirstChar: 117
      LastChar: 117
      FontDescriptor: 
       FontName: FDEOMO+AdvP4A5FDB
       Flags: Nonsymbolic
       FontBBox: 0, -239, 979, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEFKD+AdvOT5fa4e291+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: FDEFKD+AdvOT5fa4e291+20
       Flags: Nonsymbolic
       FontBBox: 19, -208, 947, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDEFKB+AdvOT5fa4e291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: FDEFKB+AdvOT5fa4e291+fb
       Flags: Symbolic
       FontBBox: 40, 0, 572, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FDENAH+AdvOTf2586c63+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: FDENAH+AdvOTf2586c63+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2020-03-20T17:08:59+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2020-03-20T17:09:17+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2020-03-20T17:09:17+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.10 (Windows)</pdf:Producer>
         <pdf:Keywords>Familial pancreatic cancer,Panel sequencing,DNA repair and hereditary cancer genes,Pathogenic variants</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ebiom.2020.102675</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">EBioMedicine, 53 (2020) 102675. doi:10.1016/j.ebiom.2020.102675</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Familial pancreatic cancer</rdf:li>
               <rdf:li>Panel sequencing</rdf:li>
               <rdf:li>DNA repair and hereditary cancer genes</rdf:li>
               <rdf:li>Pathogenic variants</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Julie Earl</rdf:li>
               <rdf:li>Cristina Galindo-Pumariño</rdf:li>
               <rdf:li>Jessica Encinas</rdf:li>
               <rdf:li>Emma Barreto</rdf:li>
               <rdf:li>Maria E. Castillo</rdf:li>
               <rdf:li>Vanessa Pachón</rdf:li>
               <rdf:li>Reyes Ferreiro</rdf:li>
               <rdf:li>Mercedes Rodríguez-Garrote</rdf:li>
               <rdf:li>Silvia González-Martínez</rdf:li>
               <rdf:li>Teresa Ramon y Cajal</rdf:li>
               <rdf:li>Luis Robles Diaz</rdf:li>
               <rdf:li>Isabel Chirivella-Gonzalez</rdf:li>
               <rdf:li>Montse Rodriguez</rdf:li>
               <rdf:li>Eva Martínez de Castro</rdf:li>
               <rdf:li>David García-Seisdedos</rdf:li>
               <rdf:li>Gloria Muñoz</rdf:li>
               <rdf:li>Juan Manuel Rosa Rosa</rdf:li>
               <rdf:li>Mirari Marquez</rdf:li>
               <rdf:li>Nuría Malats</rdf:li>
               <rdf:li>Alfredo Carrato</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:c243bbef-2d62-4cfc-a403-6c184dbac298</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>© 2020 The Author(s). Published by Elsevier B.V.</prism:copyright>
         <prism:publicationName>EBioMedicine</prism:publicationName>
         <prism:issn>2352-3964</prism:issn>
         <prism:volume>53</prism:volume>
         <prism:doi>10.1016/j.ebiom.2020.102675</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ebiom.2020.102675</prism:url>
         <prism:startingPage>102675</prism:startingPage>
         <prism:pageRange>102675</prism:pageRange>
         <prism:coverDisplayDate>March 2020</prism:coverDisplayDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1016/j.ebiom.2020.102675</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:AuthoritativeDomain>
            <rdf:Bag>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Bag>
         </pdfx:AuthoritativeDomain>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:DOI>10.1016/j.ebiom.2020.102675</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 505, 601, 534, 629
      Annotation: 
       Subtype: Link
       Rect: 84, 560, 88, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 90, 560, 95, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 97, 555, 101, 565
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 234, 560, 238, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 240, 560, 245, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 320, 560, 324, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 398, 560, 402, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 484, 560, 488, 570
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 118, 547, 122, 557
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 124, 547, 129, 557
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 202, 547, 206, 557
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 350, 547, 354, 557
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 356, 547, 360, 557
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 162, 534, 166, 544
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 273, 534, 277, 544
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 358, 534, 363, 544
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 167, 521, 171, 531
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 263, 521, 266, 531
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 381, 521, 385, 531
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 155, 508, 159, 518
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 230, 508, 234, 518
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 349, 508, 352, 518
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 432, 508, 434, 518
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 436, 508, 440, 518
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 103, 495, 106, 505
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 108, 495, 112, 505
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 190, 495, 195, 505
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 196, 495, 201, 505
       Destination: 351
      Annotation: 
       Subtype: Link
       Rect: 392, 146, 559, 153
      Annotation: 
       Subtype: Link
       Rect: 99, 83, 178, 89
      Annotation: 
       Subtype: Link
       Rect: 42, 66, 173, 72
      Annotation: 
       Subtype: Link
       Rect: 397, 57, 546, 63
      Annotation: 
       Subtype: Link
       Rect: 256, 749, 348, 755
      Annotation: 
       Subtype: Link
       Rect: 328, 721, 379, 729
      Annotation: 
       Subtype: Link
       Rect: 281, 666, 402, 674
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 175, 236, 185, 244
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 54, 215, 64, 223
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 196, 183, 205, 191
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 133, 162, 142, 170
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 245, 162, 254, 170
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 145, 152, 154, 160
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 273, 152, 283, 160
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 249, 141, 258, 149
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 53, 110, 58, 118
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 60, 110, 69, 118
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 131, 79, 145, 87
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 119, 47, 128, 55
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 130, 47, 139, 55
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 304, 685, 313, 693
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 315, 685, 324, 693
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 517, 643, 526, 651
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 527, 643, 537, 651
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 538, 643, 548, 651
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 370, 517, 385, 525
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 338, 444, 347, 452
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 349, 444, 358, 452
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 323, 68, 475, 76
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 350, 185, 358
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 181, 78, 293, 86
      Annotation: 
       Subtype: Link
       Rect: 42, 68, 70, 76
      Annotation: 
       Subtype: Link
       Rect: 111, 68, 293, 76
      Annotation: 
       Subtype: Link
       Rect: 42, 57, 81, 65
      Annotation: 
       Subtype: Link
       Rect: 269, 57, 293, 65
      Annotation: 
       Subtype: Link
       Rect: 42, 47, 164, 55
      Annotation: 
       Subtype: Link
       Rect: 402, 570, 538, 578
      Annotation: 
       Subtype: Link
       Rect: 465, 538, 562, 546
      Annotation: 
       Subtype: Link
       Rect: 311, 528, 396, 536
      Annotation: 
       Subtype: Link
       Rect: 348, 381, 460, 389
      Annotation: 
       Subtype: Link
       Rect: 464, 235, 528, 243
      Annotation: 
       Subtype: Link
       Rect: 533, 235, 547, 243
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 464, 68, 490, 76
       Destination: 48
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 533, 219, 541
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 254, 439, 279, 447
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 165, 408, 190, 416
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 226, 313, 248, 321
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 228, 303, 250, 311
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 492, 315, 517, 323
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 335, 273, 358, 281
       Destination: 62
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 205, 319, 207, 325
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 213, 302, 215, 308
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 192, 276, 195, 282
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 210, 259, 212, 265
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 227, 242, 230, 248
       Destination: 62
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 434, 116, 442
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 148, 141, 157, 149
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 159, 141, 168, 149
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 170, 141, 179, 149
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 113, 47, 122, 55
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 124, 47, 133, 55
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 301, 612, 316, 619
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 301, 580, 316, 588
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 485, 559, 494, 567
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 496, 559, 505, 567
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 502, 538, 517, 546
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 418, 465, 432, 473
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 359, 381, 368, 389
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 440, 350, 454, 358
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 301, 298, 315, 306
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 505, 256, 552, 264
      Annotation: 
       Subtype: Link
       Rect: 301, 245, 491, 253
      Annotation: 
       Subtype: Link
       Rect: 457, 214, 471, 222
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 494, 162, 508, 170
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 453, 78, 468, 86
       Destination: 142
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 706, 291, 714
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 75, 632, 89, 640
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 168, 559, 177, 567
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 179, 559, 188, 567
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 59, 528, 68, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 70, 528, 79, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 81, 528, 90, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 92, 528, 101, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 103, 528, 112, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 114, 528, 123, 536
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 237, 496, 252, 504
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 128, 455, 143, 463
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 42, 235, 56, 243
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 473, 413, 513, 421
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 520, 413, 560, 421
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 311, 403, 352, 411
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 371, 403, 407, 411
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 411, 246, 519, 254
      Annotation: 
       Subtype: Link
       Rect: 326, 206, 562, 213
      Annotation: 
       Subtype: Link
       Rect: 326, 198, 562, 205
      Annotation: 
       Subtype: Link
       Rect: 326, 190, 371, 197
      Annotation: 
       Subtype: Link
       Rect: 326, 183, 562, 189
      Annotation: 
       Subtype: Link
       Rect: 326, 175, 562, 181
      Annotation: 
       Subtype: Link
       Rect: 326, 167, 371, 173
      Annotation: 
       Subtype: Link
       Rect: 326, 159, 562, 165
      Annotation: 
       Subtype: Link
       Rect: 326, 151, 562, 157
      Annotation: 
       Subtype: Link
       Rect: 326, 143, 506, 149
      Annotation: 
       Subtype: Link
       Rect: 326, 135, 562, 141
      Annotation: 
       Subtype: Link
       Rect: 326, 127, 562, 133
      Annotation: 
       Subtype: Link
       Rect: 326, 119, 478, 125
      Annotation: 
       Subtype: Link
       Rect: 326, 111, 562, 117
      Annotation: 
       Subtype: Link
       Rect: 326, 103, 562, 109
      Annotation: 
       Subtype: Link
       Rect: 326, 95, 449, 101
      Annotation: 
       Subtype: Link
       Rect: 507, 71, 562, 77
      Annotation: 
       Subtype: Link
       Rect: 326, 63, 449, 69
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 719, 222, 725
      Annotation: 
       Subtype: Link
       Rect: 202, 695, 280, 701
      Annotation: 
       Subtype: Link
       Rect: 224, 671, 283, 678
      Annotation: 
       Subtype: Link
       Rect: 48, 663, 68, 670
      Annotation: 
       Subtype: Link
       Rect: 79, 631, 279, 638
      Annotation: 
       Subtype: Link
       Rect: 209, 615, 283, 622
      Annotation: 
       Subtype: Link
       Rect: 48, 607, 141, 614
      Annotation: 
       Subtype: Link
       Rect: 48, 599, 283, 606
      Annotation: 
       Subtype: Link
       Rect: 48, 591, 283, 598
      Annotation: 
       Subtype: Link
       Rect: 48, 583, 121, 590
      Annotation: 
       Subtype: Link
       Rect: 79, 568, 245, 574
      Annotation: 
       Subtype: Link
       Rect: 48, 560, 283, 566
      Annotation: 
       Subtype: Link
       Rect: 48, 552, 283, 558
      Annotation: 
       Subtype: Link
       Rect: 48, 544, 184, 550
      Annotation: 
       Subtype: Link
       Rect: 48, 536, 283, 542
      Annotation: 
       Subtype: Link
       Rect: 48, 528, 207, 534
      Annotation: 
       Subtype: Link
       Rect: 48, 520, 283, 526
      Annotation: 
       Subtype: Link
       Rect: 48, 512, 283, 518
      Annotation: 
       Subtype: Link
       Rect: 48, 504, 222, 510
      Annotation: 
       Subtype: Link
       Rect: 233, 480, 283, 486
      Annotation: 
       Subtype: Link
       Rect: 48, 472, 163, 478
      Annotation: 
       Subtype: Link
       Rect: 48, 464, 283, 470
      Annotation: 
       Subtype: Link
       Rect: 48, 456, 283, 462
      Annotation: 
       Subtype: Link
       Rect: 48, 448, 156, 454
      Annotation: 
       Subtype: Link
       Rect: 127, 424, 260, 430
      Annotation: 
       Subtype: Link
       Rect: 94, 400, 230, 407
      Annotation: 
       Subtype: Link
       Rect: 65, 376, 149, 383
      Annotation: 
       Subtype: Link
       Rect: 48, 368, 141, 375
      Annotation: 
       Subtype: Link
       Rect: 144, 368, 283, 375
      Annotation: 
       Subtype: Link
       Rect: 48, 360, 283, 367
      Annotation: 
       Subtype: Link
       Rect: 48, 352, 281, 359
      Annotation: 
       Subtype: Link
       Rect: 138, 320, 274, 327
      Annotation: 
       Subtype: Link
       Rect: 48, 313, 283, 319
      Annotation: 
       Subtype: Link
       Rect: 48, 305, 283, 311
      Annotation: 
       Subtype: Link
       Rect: 48, 297, 243, 303
      Annotation: 
       Subtype: Link
       Rect: 193, 281, 283, 287
      Annotation: 
       Subtype: Link
       Rect: 48, 273, 103, 279
      Annotation: 
       Subtype: Link
       Rect: 400, 719, 546, 725
      Annotation: 
       Subtype: Link
       Rect: 502, 695, 552, 701
      Annotation: 
       Subtype: Link
       Rect: 317, 687, 409, 693
      Annotation: 
       Subtype: Link
       Rect: 317, 679, 552, 686
      Annotation: 
       Subtype: Link
       Rect: 317, 671, 552, 678
      Annotation: 
       Subtype: Link
       Rect: 317, 663, 501, 670
      Annotation: 
       Subtype: Link
       Rect: 478, 639, 552, 646
      Annotation: 
       Subtype: Link
       Rect: 317, 631, 385, 638
      Annotation: 
       Subtype: Link
       Rect: 334, 599, 480, 606
      Annotation: 
       Subtype: Link
       Rect: 317, 576, 552, 582
      Annotation: 
       Subtype: Link
       Rect: 317, 568, 552, 574
      Annotation: 
       Subtype: Link
       Rect: 317, 560, 429, 566
      Annotation: 
       Subtype: Link
       Rect: 317, 552, 552, 558
      Annotation: 
       Subtype: Link
       Rect: 317, 544, 552, 550
      Annotation: 
       Subtype: Link
       Rect: 317, 536, 552, 542
      Annotation: 
       Subtype: Link
       Rect: 317, 528, 405, 534
      Annotation: 
       Subtype: Link
       Rect: 317, 520, 552, 526
      Annotation: 
       Subtype: Link
       Rect: 317, 512, 552, 518
      Annotation: 
       Subtype: Link
       Rect: 317, 504, 374, 510
      Annotation: 
       Subtype: Link
       Rect: 317, 496, 552, 502
      Annotation: 
       Subtype: Link
       Rect: 317, 488, 552, 494
      Annotation: 
       Subtype: Link
       Rect: 317, 480, 385, 486
      Annotation: 
       Subtype: Link
       Rect: 317, 472, 552, 478
      Annotation: 
       Subtype: Link
       Rect: 317, 464, 552, 470
      Annotation: 
       Subtype: Link
       Rect: 317, 456, 392, 462
      Annotation: 
       Subtype: Link
       Rect: 317, 448, 552, 454
      Annotation: 
       Subtype: Link
       Rect: 317, 440, 552, 446
      Annotation: 
       Subtype: Link
       Rect: 317, 432, 552, 438
      Annotation: 
       Subtype: Link
       Rect: 317, 424, 358, 430
      Annotation: 
       Subtype: Link
       Rect: 317, 416, 552, 422
      Annotation: 
       Subtype: Link
       Rect: 317, 408, 552, 415
      Annotation: 
       Subtype: Link
       Rect: 317, 400, 552, 407
      Annotation: 
       Subtype: Link
       Rect: 317, 392, 352, 399
      Annotation: 
       Subtype: Link
       Rect: 317, 384, 552, 391
      Annotation: 
       Subtype: Link
       Rect: 317, 376, 552, 383
      Annotation: 
       Subtype: Link
       Rect: 317, 368, 549, 375
      Annotation: 
       Subtype: Link
       Rect: 317, 360, 552, 367
      Annotation: 
       Subtype: Link
       Rect: 317, 352, 552, 359
      Annotation: 
       Subtype: Link
       Rect: 317, 344, 552, 351
      Annotation: 
       Subtype: Link
       Rect: 317, 336, 344, 343
      Annotation: 
       Subtype: Link
       Rect: 317, 305, 402, 311
      Annotation: 
       Subtype: Link
       Rect: 317, 297, 552, 303
      Annotation: 
       Subtype: Link
       Rect: 317, 289, 552, 295
      Annotation: 
       Subtype: Link
       Rect: 317, 281, 425, 287
      Annotation: 
       Subtype: Link
       Rect: 317, 273, 552, 279
      Annotation: 
       Subtype: Link
       Rect: 317, 265, 552, 271
      Annotation: 
       Subtype: Link
       Rect: 317, 257, 419, 263
  Checksum: ea94bda3
   Type: CRC32
  Checksum: 801d6fba48cdc808fe723c5750105bac
   Type: MD5
  Checksum: a672cdea123a18c177caf6aeac8d181f92d1c2b8
   Type: SHA-1