c848e105cd97ba967e695faa03d12c30  283708.pdf
38efa021a2771ad580a6c98db8ffedb4d3d8af10  283708.pdf
2fb7eb97e6b410f89b5a64a881022e9a4361349596cf5a12b08e0d03fdddb07f  283708.pdf

Creator:        Adobe InDesign CS6 (Windows)
Producer:       Adobe PDF Library 10.0.1
CreationDate:   Tue Apr 28 05:00:47 2020 CEST
ModDate:        Fri Oct 20 11:22:24 2023 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      546035 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ZEOXKU+ArialMT                       CID TrueType      Identity-H       yes yes yes    258  0
SFGUQI+HelveticaNeueLTStd-BdCn       Type 1C           Custom           yes yes yes    244  0
YXBWWW+HelveticaNeueLTStd-Bd         Type 1C           WinAnsi          yes yes yes    245  0
TNOSEG+HelveticaNeueLTStd-Roman      Type 1C           Custom           yes yes yes    246  0
JYOKUA+HelveticaLTStd-BoldCond       Type 1C           WinAnsi          yes yes yes    259  0
XPTYIY+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    260  0
UIKGSE+HelveticaNeueLTStd-CnO        Type 1C           Custom           yes yes yes    261  0
XBPLIY+NewBaskerville-Roman          Type 1C           WinAnsi          yes yes yes    274  0
Helvetica                            Type 1            WinAnsi          no  no  no     325  0
YXBWWW+BookAntiqua-Bold              TrueType          WinAnsi          yes yes yes    251  0
XPTYIY+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    310  0
UIKGSE+HelveticaNeueLTStd-CnO        Type 1C           Custom           yes yes yes    312  0
SFGUQI+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes    314  0
SWCHQI+Symbol                        Type 1C           Custom           yes yes yes    178  0
XPTYIY+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    176  0
UIKGSE+HelveticaNeueLTStd-CnO        Type 1C           Custom           yes yes yes    174  0
SFGUQI+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes    172  0
PPOPAO+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    183  0
XPTYIY+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes     49  0
UIKGSE+HelveticaNeueLTStd-CnO        Type 1C           Custom           yes yes yes     51  0
SFGUQI+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes     53  0
XPTYIY+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    190  0
UIKGSE+HelveticaNeueLTStd-CnO        Type 1C           Custom           yes yes yes    188  0
SFGUQI+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes    186  0
NMPDYS+HelveticaNeueLTStd-It         Type 1C           Custom           yes yes yes    194  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-10-21 02:46:59 CEST
 RepresentationInformation: 283708.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-10-20 11:24:00 CEST
  Size: 546035
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 368
   FreeObjects: 20
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Rationale and methodology for a European pooled analysis of postmarketing interventional and observational studies of insulin 最氀愀爀最椀渀攀 ㌀　　 唀⼀洀䰀 椀渀 搀椀愀戀攀琀攀猀㨀 瀀爀漀琀漀挀漀氀 漀昀 刀䔀䄀䰀䤀ꀀ瀀爀漀樀攀挀琩㸾੥湤潢樊㈰〠〠潢樊㰼⽄⠵㐱愶㍣㌭昹㝤ⴴ慡戭慢搸ⴷ㘹慣㑢ㄷ㔰㐮楮摤㩂潯歭慲欠ㄺ㈱ㄴ
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methods and analysis
        Children: 
         Item: 
          Title: Overall project design
         Item: 
          Title: Patient population
         Item: 
          Title: Outcomes
         Item: 
          Title: Statistical analyses
         Item: 
          Title: REALI project progress
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Strengths and limitations
         Item: 
          Title: ETHICS AND DISSEMINATION
          Children: 
           Item: 
            Title: Ethical considerations
           Item: 
            Title: Dissemination plan
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign CS6 (Windows)
    Producer: Adobe PDF Library 10.0.1
    CreationDate: Tue Apr 28 05:00:47 CEST 2020
    ModDate: Fri Oct 20 04:22:24 CEST 2023
   ID: 0x10b372be771f58468efdbc458bdeb8f0, 0x79b1cfead11db2110a00bd0810000000
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1184
      ImageHeight: 626
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1481
      ImageHeight: 637
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ZEOXKU+ArialMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: PPOPAO+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: XBPLIY+NewBaskerville-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 239
      FontDescriptor: 
       FontName: XBPLIY+NewBaskerville-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -205, -272, 1207, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SWCHQI+Symbol
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: SWCHQI+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NMPDYS+HelveticaNeueLTStd-It
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: NMPDYS+HelveticaNeueLTStd-It
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -214, 1106, 957
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JYOKUA+HelveticaLTStd-BoldCond
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: JYOKUA+HelveticaLTStd-BoldCond
       Flags: Nonsymbolic
       FontBBox: -169, -250, 1091, 991
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: XPTYIY+HelveticaNeueLTStd-Cn
      FontSubset: true
      FirstChar: 30
      LastChar: 233
      FontDescriptor: 
       FontName: XPTYIY+HelveticaNeueLTStd-Cn
       Flags: Nonsymbolic
       FontBBox: -164, -212, 1000, 932
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SFGUQI+HelveticaNeueLTStd-BdCn
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: SFGUQI+HelveticaNeueLTStd-BdCn
       Flags: Nonsymbolic
       FontBBox: -164, -224, 1066, 961
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Helvetica
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: UIKGSE+HelveticaNeueLTStd-CnO
      FontSubset: true
      FirstChar: 31
      LastChar: 116
      FontDescriptor: 
       FontName: UIKGSE+HelveticaNeueLTStd-CnO
       Flags: Nonsymbolic, Italic
       FontBBox: -171, -272, 1068, 932
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YXBWWW+HelveticaNeueLTStd-Bd
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: YXBWWW+HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TNOSEG+HelveticaNeueLTStd-Roman
      FontSubset: true
      FirstChar: 29
      LastChar: 239
      FontDescriptor: 
       FontName: TNOSEG+HelveticaNeueLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1076, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: YXBWWW+BookAntiqua-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: YXBWWW+BookAntiqua-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -134, -337, 1193, 1021
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ZEOXKU+ArialMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZEOXKU+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile2: true
     Font: 
      BaseFont: PPOPAO+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: PPOPAO+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.2.1-c043 52.389687, 2009/06/02-13:20:35        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:identifier>doi:bmjopen-2019-033659</dc:identifier>
         <dc:format>application/pdf</dc:format>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2020-04-28T04:00:47+01:00</xmp:CreateDate>
         <xmp:MetadataDate>2023-10-20T02:22:24-07:00</xmp:MetadataDate>
         <xmp:ModifyDate>2023-10-20T02:22:24-07:00</xmp:ModifyDate>
         <xmp:CreatorTool>Adobe InDesign CS6 (Windows)</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:InstanceID>uuid:eacfb273-1dd1-11b2-0a00-bf0038e3fdff</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:B2C59A163194E611BD009A7CB80B8EC7</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:C3E13874FC88EA11B9E1E5343423B0E7</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:C2E13874FC88EA11B9E1E5343423B0E7</stRef:instanceID>
            <stRef:documentID>xmp.did:12BEE6AC550DE8118634A2E26D244B8E</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:B2C59A163194E611BD009A7CB80B8EC7</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign CS6 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2020-04-28T04:00:47+01:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:jobID>541a63c3-f97d-4aab-abd8-769ac4b17504</pdfx:jobID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Adobe PDF Library 10.0.1</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 38, 34, 63, 18
      Annotation: 
       Subtype: Link
       Rect: 226, 557, 235, 544
      Annotation: 
       Subtype: Link
       Rect: 38, 197, 134, 174
      Annotation: 
       Subtype: Link
       Rect: 375, 147, 385, 135
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 446, 87, 457, 75
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 83, 723, 98, 711
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 235, 711, 239, 699
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 190, 603, 193, 591
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 268, 555, 277, 543
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 129, 507, 141, 495
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 136, 435, 152, 423
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 250, 399, 266, 387
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 71, 387, 77, 375
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 155, 315, 162, 303
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 253, 231, 260, 219
       ActionDest: 88
      Annotation: 
       Subtype: Link
       Rect: 235, 207, 242, 195
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 45, 195, 52, 183
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 151, 195, 158, 183
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 281, 111, 288, 99
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 352, 747, 359, 735
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 306, 217, 342, 206
       ActionDest: 36
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 204, 136, 211, 124
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 357, 159, 364, 147
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 166, 562, 182, 550
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 44, 334, 80, 322
       ActionDest: 60
      Annotation: 
       Subtype: Link
       Rect: 90, 229, 122, 217
       ActionDest: 81
      Annotation: 
       Subtype: Link
       Rect: 137, 169, 167, 157
       ActionDest: 81
      Annotation: 
       Subtype: Link
       Rect: 306, 663, 336, 651
       ActionDest: 81
      Annotation: 
       Subtype: Link
       Rect: 358, 567, 364, 555
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 523, 471, 530, 459
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 492, 315, 499, 303
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 147, 265, 135
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 135, 675, 142, 663
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 230, 627, 237, 615
       ActionDest: 125
      Annotation: 
       Subtype: Link
       Rect: 380, 538, 521, 529
      Annotation: 
       Subtype: Link
       Rect: 352, 511, 469, 502
      Annotation: 
       Subtype: Link
       Rect: 452, 452, 474, 443
      Annotation: 
       Subtype: Link
       Rect: 462, 427, 539, 418
      Annotation: 
       Subtype: Link
       Rect: 322, 393, 370, 384
      Annotation: 
       Subtype: Link
       Rect: 434, 359, 481, 350
      Annotation: 
       Subtype: Link
       Rect: 451, 333, 506, 324
      Annotation: 
       Subtype: Link
       Rect: 322, 299, 369, 290
      Annotation: 
       Subtype: Link
       Rect: 374, 265, 421, 256
      Annotation: 
       Subtype: Link
       Rect: 384, 248, 404, 239
      Annotation: 
       Subtype: Link
       Rect: 379, 223, 430, 214
      Annotation: 
       Subtype: Link
       Rect: 506, 206, 550, 197
      Annotation: 
       Subtype: Link
       Rect: 476, 163, 548, 154
      Annotation: 
       Subtype: Link
       Rect: 394, 121, 467, 112
      Annotation: 
       Subtype: Link
       Rect: 343, 78, 416, 69
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 211, 747, 258, 738
      Annotation: 
       Subtype: Link
       Rect: 102, 696, 174, 687
      Annotation: 
       Subtype: Link
       Rect: 101, 662, 174, 653
      Annotation: 
       Subtype: Link
       Rect: 144, 628, 191, 619
      Annotation: 
       Subtype: Link
       Rect: 175, 602, 221, 593
      Annotation: 
       Subtype: Link
       Rect: 235, 577, 282, 568
      Annotation: 
       Subtype: Link
       Rect: 187, 543, 235, 534
      Annotation: 
       Subtype: Link
       Rect: 228, 517, 275, 508
      Annotation: 
       Subtype: Link
       Rect: 469, 746, 543, 738
      Annotation: 
       Subtype: Link
       Rect: 322, 738, 536, 729
      Annotation: 
       Subtype: Link
       Rect: 322, 729, 542, 721
      Annotation: 
       Subtype: Link
       Rect: 322, 721, 385, 712
      Annotation: 
       Subtype: Link
       Rect: 358, 662, 430, 653
      Annotation: 
       Subtype: Link
       Rect: 509, 636, 550, 627
      Annotation: 
       Subtype: Link
       Rect: 322, 628, 361, 619
      Annotation: 
       Subtype: Link
       Rect: 322, 585, 395, 576
      Annotation: 
       Subtype: Link
       Rect: 423, 551, 464, 542
      Annotation: 
       Subtype: Link
       Rect: 517, 517, 549, 508
      Annotation: 
       Subtype: Link
       Rect: 322, 509, 361, 500
      Annotation: 
       Subtype: Link
       Rect: 508, 492, 554, 483
      Annotation: 
       Subtype: Link
       Rect: 322, 483, 355, 474
      Annotation: 
       Subtype: Link
       Rect: 576, 273, 587, 371
  Checksum: 293d5e6c
   Type: CRC32
  Checksum: c848e105cd97ba967e695faa03d12c30
   Type: MD5
  Checksum: 38efa021a2771ad580a6c98db8ffedb4d3d8af10
   Type: SHA-1