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Title:          Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases
Subject:        Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of “hypermutator P. aeruginosa strain”. This phenomenon has been observed in people with bronchiectasis, CF, and the “exacerbator” COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.
Keywords:       Pseudomonas aeruginosa; bronchiectasis; cystic fibrosis; COPD; asthma; chronic bronchial infection
Author:         Marta Garcia-Clemente, David de la Rosa, Luis Máiz, Rosa Girón, Marina Blanco, Casilda Olveira, Rafael Canton and Miguel Angel Martinez-García
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   Info: 
    Title: Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases
    Author: Marta Garcia-Clemente, David de la Rosa, Luis Máiz, Rosa Girón, Marina Blanco, Casilda Olveira, Rafael Canton and Miguel Angel Martinez-García
    Subject: Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of P. aeruginosa over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of “hypermutator P. aeruginosa strain”. This phenomenon has been observed in people with bronchiectasis, CF, and the “exacerbator” COPD phenotype. From a clinical point of view, a chronic bronchial infection of P. aeruginosa has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of P. aeruginosa infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.
    Keywords: Pseudomonas aeruginosa; bronchiectasis; cystic fibrosis; COPD; asthma; chronic bronchial infection
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  Checksum: e99d83f8
   Type: CRC32
  Checksum: dbb3a89c31c09f494f3048461ab28a97
   Type: MD5
  Checksum: 5b14fa4c3ea7264253a8f9d368b9c2ce82b76c01
   Type: SHA-1