7ed62217b197fe157e41fdd8f966230b 283718.pdf d6e0281cac0f975094c8b59ccec8c1e2555f783b 283718.pdf b554379787360631e42029605186204e7381aa0b1645e704871410259b66fff4 283718.pdf Title: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-68848-9 Author: Yixin Gao Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jul 15 13:58:32 2020 CEST ModDate: Thu Jul 16 13:33:49 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1239661 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OXWDKQ+Corbel-Bold CID TrueType Identity-H yes yes yes 75 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 379 0 MinionPro-Regular Type 1C Custom yes no yes 82 0 Corbel-Bold2 TrueType WinAnsi yes no yes 78 0 Corbel2 TrueType WinAnsi yes no yes 80 0 TZLHCG+Corbel CID TrueType Identity-H yes yes yes 81 0 IGANMY+Wingdings-Regular Type 1C WinAnsi yes yes yes 380 0 Corbel2 TrueType WinAnsi yes no yes 415 0 UMUEMN+MinionPro-BoldIt Type 1C WinAnsi yes yes yes 76 0 MinionPro-It Type 1C Custom yes no yes 77 0 MinionPro-Bold Type 1C Custom yes no yes 79 0 SFIJOI+MinionPro-Regular4 Type 1C Custom yes yes no 126 0 SFIJOI+MinionPro-It4 Type 1C Custom yes yes no 127 0 SFIJOI+MTSYN3 Type 1C Custom yes yes no 128 0 SFIJOI+MTMI3 Type 1C Custom yes yes no 129 0 SFIJOI+MTSYN Type 1C Custom yes yes no 130 0 SFIJOI+MTMI4 Type 1C Custom yes yes no 131 0 SFIJOI+MinionPro-It2 Type 1C Custom yes yes no 132 0 SFIJOI+MTMI2 Type 1C Custom yes yes no 133 0 SFIJOI+MinionPro-Regular3 Type 1C Custom yes yes no 134 0 SFIJOI+MinionPro-Regular2 Type 1C Custom yes yes no 135 0 SFIJOI+MTSYN2 Type 1C Custom yes yes no 136 0 SFIJOI+MinionPro-It3 Type 1C Custom yes yes no 137 0 SFIJOI+MTMI Type 1C Custom yes yes no 138 0 SFIJOI+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 276 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-24 02:27:26 CEST RepresentationInformation: 283718.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-23 10:40:18 CEST Size: 1239661 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 445 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis Children: Item: Title: Anchor 2 Item: Title: Anchor 3 Item: Title: Materials and methods Children: Item: Title: GWAS data sources for LTL, ALS and other relevant traits. Item: Title: Causal effect estimation via two-sample Mendelian randomization. Item: Title: Mediation analysis to explore the mediation effect of lipids between LTL and ALSFTD. Item: Title: Results Children: Item: Title: Causal effect of LTL on ALS and FTD. Item: Title: Mediation analysis of the role between LTL, lipids and ALSFTD. Item: Title: Discussion Item: Title: Conclusions Item: Title: References Item: Title: Acknowledgements Info: Title: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis Author: Yixin Gao Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-68848-9 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jul 15 14:28:32 CEST 2020 ModDate: Thu Jul 16 13:33:49 CEST 2020 ID: 0x9ddc088f0aa0f1185e56fd07996b2be9, 0xb9255335e74473432778652b807513c2 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1993 ImageHeight: 662 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1069 ImageHeight: 660 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: TZLHCG+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: OXWDKQ+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: SFIJOI+MTSYN3 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTSYN3 Flags: Symbolic FontBBox: 0, -83, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTMI3 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTMI3 Flags: Symbolic FontBBox: 0, -207, 551, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTSYN FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTSYN Flags: Symbolic FontBBox: 0, -83, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTMI4 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTMI4 Flags: Symbolic FontBBox: 0, -207, 551, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MinionPro-It2 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-It2 Flags: Symbolic, SmallCap FontBBox: -1, -12, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTMI2 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTMI2 Flags: Symbolic FontBBox: 0, -207, 551, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MinionPro-Regular3 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-Regular3 Flags: Symbolic, SmallCap FontBBox: -2, -170, 687, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MinionPro-Regular2 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-Regular2 Flags: Symbolic, SmallCap FontBBox: -2, -170, 687, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTSYN2 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTSYN2 Flags: Symbolic FontBBox: 0, -83, 724, 736 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MinionPro-It3 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-It3 Flags: Symbolic, SmallCap FontBBox: -1, -12, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MTMI FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: SFIJOI+MTMI Flags: Symbolic FontBBox: 0, -207, 551, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UMUEMN+MinionPro-BoldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UMUEMN+MinionPro-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -230, -360, 1684, 1032 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IGANMY+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: IGANMY+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SFIJOI+MinionPro-Regular4 FontSubset: true FirstChar: 24 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-Regular4 Flags: Symbolic, SmallCap FontBBox: -2, -170, 687, 710 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SFIJOI+MinionPro-It4 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: SFIJOI+MinionPro-It4 Flags: Symbolic, SmallCap FontBBox: -1, -12, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true TrueType: Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SFIJOI+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: SFIJOI+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-Bold2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: TZLHCG+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TZLHCG+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: OXWDKQ+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OXWDKQ+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2020-07-15T17:28:32+05:30 Springer 2020-07-16T13:33:49+02:00 2020-07-16T13:33:49+02:00 application/pdf https://doi.org/10.1038/s41598-020-68848-9 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-020-68848-9 Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis Yixin Gao Ting Wang Xinghao Yu Raffaele Ferrari Dena G. Hernandez Michael A. Nalls Jonathan D. Rohrer Adaikalavan Ramasamy John B. J. Kwok Carol Dobson-Stone William S. Brooks Peter R. Schofield Glenda M. Halliday John R. Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J. Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Diego Albani Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R. A. Mackenzie Ging-Yuek R. Hsiung David M. A. Mann Jordan Grafman Christopher M. Morris Johannes Attems Timothy D. Griffiths Ian G. McKeith Alan J. Thomas Pietro Pietrini Edward D. Huey Eric M. Wassermann Atik Baborie Evelyn Jaros Michael C. Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B. Rowe Johannes C. M. Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M. Van Deerlin Murray Grossman John Q. Trojanowski Julie van der Zee Marc Cruts Christine Van Broeckhoven Stefano F. Cappa Isabelle Leber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E. Nielsen Lena E. Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N. Rossor Nick C. Fox Jason D. Warren Maria Grazia Spillantini Huw R. Morris Patrizia Rizzu Peter Heutink Julie S. Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C. Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W. Dickson Neill R. Graff-Radford Ronald C. Petersen David Knopman Keith A. Josephs Bradley F. Boeve Joseph E. Parisi William W. Seeley Bruce L. Miller Anna M. Karydas Howard Rosen John C. van Swieten Elise G. P. Dopper Harro Seelaar Yolande A. L. Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A. Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Thibaud Lebouvier Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B. Singleton John Hardy Parastoo Momeni Huashuo Zhao Ping Zeng 10.1038/s41598-020-68848-9 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-020-68848-9 10.1038/s41598-020-68848-9 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-020-68848-9 noindex springer.com springerlink.com VoR uuid:1ab8b643-c4cb-4fb6-8233-89088156f88a uuid:19814b01-1221-400f-89e7-c159e19a7c01 default 1 converted uuid:3efdc0bd-d271-4867-a6e0-52debb494c3f converted to PDF/A-2b pdfToolbox 2020-07-15T17:29:53+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 188, 284, 191, 271 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 194, 284, 197, 271 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 204, 274, 206, 261 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 516, 244, 519, 231 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 411, 214, 414, 201 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 282, 194, 284, 181 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 288, 194, 293, 181 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 437, 174, 443, 161 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 356, 164, 361, 151 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 386, 154, 390, 141 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 537, 134, 543, 121 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 199, 124, 205, 111 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 318, 124, 324, 111 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 481, 656, 556, 638 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 207, 471, 212, 459 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 192, 441, 197, 429 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 198, 441, 204, 429 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 460, 431, 466, 419 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 467, 431, 473, 419 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 352, 401, 357, 389 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 375, 391, 381, 379 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 384, 391, 390, 379 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 427, 381, 432, 369 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 435, 381, 441, 369 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 306, 279, 312, 267 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 246, 249, 251, 237 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 184, 229, 189, 217 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 378, 229, 384, 217 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 385, 229, 391, 217 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 394, 229, 399, 217 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 213, 179, 219, 167 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 224, 179, 319, 167 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 361, 169, 365, 157 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 437, 149, 442, 137 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 149, 451, 137 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 380, 139, 385, 127 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 191, 129, 197, 117 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 398, 99, 404, 87 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 438, 99, 444, 87 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 272, 79, 276, 67 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 391, 719, 396, 709 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 391, 707, 396, 698 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 391, 695, 396, 686 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 684, 396, 674 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 672, 396, 663 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 660, 393, 651 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 391, 649, 396, 639 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 391, 637, 396, 628 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 625, 396, 616 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 614, 393, 604 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 391, 602, 396, 593 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 590, 396, 581 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 579, 396, 569 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 567, 396, 557 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 391, 555, 396, 546 Flags: Print AppearanceDictionary: true Destination: 286 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 518, 107, 523, 95 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 526, 107, 532, 95 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 399, 97, 405, 85 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 506, 97, 511, 85 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 224, 87, 230, 75 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 296, 87, 302, 75 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 396, 87, 401, 75 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 403, 87, 408, 75 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 345, 67, 351, 55 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 295, 568, 301, 556 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 409, 558, 415, 546 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 416, 558, 422, 546 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 440, 481, 444, 472 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 446, 469, 450, 460 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 458, 450, 448 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 446, 450, 437 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 434, 450, 425 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 456, 423, 460, 413 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 444, 411, 448, 402 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 399, 450, 390 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 388, 450, 378 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 376, 450, 367 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 446, 364, 450, 355 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 456, 353, 460, 343 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 456, 341, 461, 331 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 444, 329, 448, 320 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 444, 318, 448, 308 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 444, 306, 448, 296 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 444, 294, 448, 285 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 444, 282, 449, 273 Flags: Print AppearanceDictionary: true Destination: 261 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 426, 528, 431, 516 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 434, 528, 440, 516 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 208, 508, 211, 496 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 212, 508, 218, 496 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 219, 508, 225, 496 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 175, 498, 181, 486 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 184, 498, 189, 486 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 330, 498, 336, 486 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 504, 498, 510, 486 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 325, 478, 329, 466 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 227, 468, 233, 456 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 260, 458, 265, 446 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 287, 406, 291, 394 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 180, 386, 184, 374 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 388, 386, 394, 374 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 395, 386, 401, 374 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 402, 386, 408, 374 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 309, 356, 313, 344 Flags: Print AppearanceDictionary: true Destination: 180 Annotation: Subtype: Link Rect: 304, 336, 308, 324 Flags: Print AppearanceDictionary: true Destination: 180 Annotation: Subtype: Link Rect: 528, 316, 533, 304 Flags: Print AppearanceDictionary: true Destination: 180 Annotation: Subtype: Link Rect: 417, 276, 422, 264 Flags: Print AppearanceDictionary: true Destination: 217 Annotation: Subtype: Link Rect: 306, 226, 312, 214 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 258, 216, 262, 204 Flags: Print AppearanceDictionary: true Destination: 180 Annotation: Subtype: Link Rect: 544, 124, 549, 112 Flags: Print AppearanceDictionary: true Destination: 217 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 523, 239, 527, 227 Flags: Print AppearanceDictionary: true Destination: 237 Annotation: Subtype: Link Rect: 262, 199, 267, 187 Flags: Print AppearanceDictionary: true Destination: 217 Annotation: Subtype: Link Rect: 271, 199, 275, 187 Flags: Print AppearanceDictionary: true Destination: 237 Annotation: Subtype: Link Rect: 536, 169, 554, 157 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 159, 290, 147 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 290, 159, 295, 147 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 544, 159, 548, 147 Flags: Print AppearanceDictionary: true Destination: 237 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 433, 226, 438, 214 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 542, 216, 545, 204 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 546, 216, 552, 204 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 275, 166, 281, 154 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 284, 166, 289, 154 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 259, 156, 262, 144 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 506, 106, 511, 94 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 515, 106, 520, 94 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 163, 304, 168, 292 Flags: Print AppearanceDictionary: true Destination: 282 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 486, 724, 492, 712 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 494, 724, 499, 712 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 501, 724, 506, 712 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 419, 674, 422, 662 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 423, 674, 426, 662 Flags: Print AppearanceDictionary: true Destination: 261 Annotation: Subtype: Link Rect: 298, 654, 303, 642 Flags: Print AppearanceDictionary: true Destination: 282 Annotation: Subtype: Link Rect: 306, 654, 312, 642 Flags: Print AppearanceDictionary: true Destination: 282 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 363, 272, 521, 259 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 242, 443, 229 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 357, 131, 516, 119 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Thumb: true Page: Sequence: 11 Thumb: true Page: Sequence: 12 Thumb: true Checksum: 15d4f92b Type: CRC32 Checksum: 7ed62217b197fe157e41fdd8f966230b Type: MD5 Checksum: d6e0281cac0f975094c8b59ccec8c1e2555f783b Type: SHA-1