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object 'bm_CR67' cannot be found Offset: 1490194 MIMEtype: application/pdf PDFMetadata: Objects: 887 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: RNA quantification and eQTL discovery Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: eQTLs and i-eQTL target regions show high replication rates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: i-eQTLs and non-standard eQTLs are largely novel signals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Splicing eQTLs are enriched for neuronal information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: i-eQTLs are enriched for disease-relevant information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: ASE discovery and validation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: ASEs tag both gene level and splicing eQTLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: ASEs show biologically and disease-relevant enrichments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: Generation and processing of RNA sequencing data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: DNA extraction and genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: eQTL discovery and replication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Characterisation of unannotated transcribed intergenic regions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Validation of unannotated transcribed intergenic regions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Identification of redundant eQTLs by beta-hetereogeneity testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Identification of disease-relevant eQTLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: ASE signal discovery and replication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Characterisation of ASE signals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Investigation of the disease relevance of ASEs using randomisation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Assessment of brain cell type specificity for eQTLs and ASEs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Partitioned heritability analysis of ASE sites Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Author contributions Destination: 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Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information Sebastian Guelfi Karishma D’Sa Juan A. Botía Jana Vandrovcova Regina H. Reynolds David Zhang Daniah Trabzuni Leonardo Collado-Torres Andrew Thomason Pedro Quijada Leyton Sarah A. Gagliano Taliun Mike A. Nalls Alastair J. Noyce Aude Nicolas Mark R. Cookson Sara Bandres-Ciga J. Raphael Gibbs Dena G. Hernandez Andrew B. Singleton Xylena Reed Hampton Leonard Cornelis Blauwendraat Faraz Faghri Jose Bras Rita Guerreiro Arianna Tucci Demis A. Kia Henry Houlden Helene Plun-Favreau Kin Y Mok Nicholas W. Wood Ruth Lovering Lea R’Bibo Mie Rizig Viorica Chelban Manuela Tan Huw R. Morris Ben Middlehurst John Quinn Kimberley Billingsley Peter Holmans Kerri J. Kinghorn Patrick Lewis Valentina Escott-Price Nigel Williams Thomas Foltynie Alexis Brice Fabrice Danjou Suzanne Lesage Jean-Christophe Corvol Maria Martinez Anamika Giri Claudia Schulte Kathrin Brockmann Javier Simón-Sánchez Peter Heutink Thomas Gasser Patrizia Rizzu Manu Sharma Joshua M. Shulman Laurie Robak Steven Lubbe Niccolo E. Mencacci Steven Finkbeiner Codrin Lungu Sonja W. Scholz Ziv Gan-Or Guy A. Rouleau Lynne Krohan Jacobus J. van Hilten Johan Marinus Astrid D. Adarmes-Gómez Inmaculada Bernal-Bernal Marta Bonilla-Toribio Dolores Buiza-Rueda Fátima Carrillo Mario Carrión-Claro Pablo Mir Pilar Gómez-Garre Silvia Jesús Miguel A. Labrador-Espinosa Daniel Macias Laura Vargas-González Carlota Méndez-del-Barrio Teresa Periñán-Tocino Cristina Tejera-Parrado Monica Diez-Fairen Miquel Aguilar Ignacio Alvarez María Teresa Boungiorno Maria Carcel Pau Pastor Juan Pablo Tartari Victoria Alvarez Manuel Menéndez González Marta Blazquez Ciara Garcia Esther Suarez-Sanmartin Francisco Javier Barrero Elisabet Mondragon Rezola Jesús Alberto Bergareche Yarza Ana Gorostidi Pagola Adolfo López de Munain Arregui Javier Ruiz-Martínez Debora Cerdan Jacinto Duarte Jordi Clarimón Oriol Dols-Icardo Jon Infante Juan Marín Jaime Kulisevsky Javier Pagonabarraga Isabel Gonzalez-Aramburu Antonio Sanchez Rodriguez María Sierra Raquel Duran Clara Ruz Francisco Vives Francisco Escamilla-Sevilla Adolfo Mínguez Ana Cámara Yaroslau Compta Mario Ezquerra Maria Jose Marti Manel Fernández Esteban Muñoz Rubén Fernández-Santiago Eduard Tolosa Francesc Valldeoriola Pedro García-Ruiz Maria Jose Gomez Heredia Francisco Perez Errazquin Janet Hoenicka Adriano Jimenez-Escrig Juan Carlos Martínez-Castrillo Jose Luis Lopez-Sendon Irene Martínez Torres Cesar Tabernero Lydia Vela Alexander Zimprich Lasse Pihlstrom Sulev Koks Pille Taba Kari Majamaa Ari Siitonen Njideka U. Okubadejo Oluwadamilola O. Ojo Paola Forabosco Robert Walker Kerrin S. Small Colin Smith Adaikalavan Ramasamy John Hardy Michael E. Weale Mina Ryten Springer US Nature Communications, doi:10.1038/s41467-020-14483-x 10.1038/s41467-020-14483-x http://dx.doi.org/10.1038/s41467-020-14483-x journal Nature Communications © 2020, The Author(s) 2041-1723 10.1038/s41467-020-14483-x springer.com springerlink.com 2010-04-23 True 10.1038/s41467-020-14483-x springer.com springerlink.com Springer 2020-02-19T14:12:52+01:00 2020-02-15T14:12:48+05:30 2020-02-19T14:12:52+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:c2711a0a-fb11-4a46-a5bb-259b039838fb uuid:db4bbb3f-2fda-4ab7-ad42-24decc98f2e4 default 1 converted uuid:dee060b3-6011-4980-92f0-ae8f0990d312 converted to PDF/A-2b pdfToolbox 2020-02-15T14:14:09+05:30 2 B Regina H. Reynolds http://orcid.org/0000-0001-6470-7919 Daniah Trabzuni http://orcid.org/0000-0003-4826-9570 Leonardo Collado-Torres http://orcid.org/0000-0003-2140-308X Andrew Thomason http://orcid.org/0000-0001-8240-1614 Sarah A. Gagliano Taliun http://orcid.org/0000-0003-1306-1868 Kerrin S. Small http://orcid.org/0000-0003-4566-0005 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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