513889821e6db4dd7e3ad3fa7e2a5f34 283730.pdf 89b1aa660b4b51c47ad20886388332a80d849eff 283730.pdf cffcb90ce3f7bfee24137fbc381979f2e8cb57c1c2fe8822ae087e7cbe6a780d 283730.pdf Title: Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation–Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement Subject: Implementation Science, 2020, doi:10.1186/s13012-020-01036-5 Keywords: Clinical practice guidelines,Practice guidelines,Recommendations,Quality of health care,AGREE tool,Implementability Author: Ivan D. Florez Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Sep 16 04:20:32 2020 CEST ModDate: Fri Sep 18 13:19:20 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 339734 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 19 0 DOPAFE+NsthrkAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 17 0 DOPDDD+JlnscrAdvTTe45e47d2 Type 1C WinAnsi yes yes no 18 0 DOPDDE+RyvlndAdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 341 0 DOPDEF+HsfdklAdvTTb5929f4c Type 1C WinAnsi yes yes no 20 0 DOPDKD+VwskngAdvTT99c4c969 Type 1C WinAnsi yes yes no 22 0 DOPEJO+TbyhhdAdvTT7329fd89.I Type 1C WinAnsi yes yes no 24 0 DOPEPA+KppchjAdvTT86d47313+20 Type 1C WinAnsi yes yes no 13 0 DOPFAB+JkrprqAdvTT8861b38f.I Type 1C WinAnsi yes yes no 14 0 DOPENP+MnmlxfAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 15 0 DOPEOP+KcgxhkAdvTT86d47313 Type 1C WinAnsi yes yes no 16 0 DOPFBC+FxmjnpAdvP4C4E74 Type 1C Custom yes yes no 21 0 DOPFBD+TwxsfnAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 23 0 DOPFED+XvhwkcAdvTT83913201.I Type 1C WinAnsi yes yes no 88 0 DOPFEE+RlyjhkAdvTT43ccf47d Type 1C WinAnsi yes yes no 89 0 DOPFHD+DmqfmfAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 133 0 DOPFKE+KnhqgrAdvTT8861b38f.I+20 Type 1C WinAnsi yes yes no 6 0 DOPFLF+SjtxsjAdvTTb5929f4c+22 Type 1C Custom yes yes no 48 0 DOPFJE+XrnmctAdvTT86d47313+22 Type 1C Custom yes yes yes 39 0 DOPGCD+RqxkndAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 105 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-25 02:26:27 CEST RepresentationInformation: 283730.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-24 12:28:48 CEST Size: 339734 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab1' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab2' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab3' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab4' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab5' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab5' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 285399 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 285399 MIMEtype: application/pdf PDFMetadata: Objects: 371 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Objective Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Setting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Intervention Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Main outcome measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: CPGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: AGREE-RE-DX scores Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: AGREE II evaluations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Scoring Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Sample size calculation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Analytical framework Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: CPGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: AGREE-REX (see Table 4) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: AGREE-REX.D performance for all CPGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: AGREE-REX-D performance by type of organization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: AGREE-REX-D performance by country of CPG authoring group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: AGREE-REX-D performance by disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: AGREE II (see Table 5) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: AGREE II and AGREE-REX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Transparency Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Info: Title: Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement Author: Ivan D. Florez Subject: Implementation Science, 2020, doi:10.1186/s13012-020-01036-5 Keywords: Clinical practice guidelines,Practice guidelines,Recommendations,Quality of health care,AGREE tool,Implementability Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Sep 16 04:20:32 CEST 2020 ModDate: Fri Sep 18 13:19:20 CEST 2020 ID: 0xaaf77697780f2e96c0fde14362a892e6, 0xd737d2fa351c00274c2633375affd23c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DOPFHD+DmqfmfAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DOPFHD+DmqfmfAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFKE+KnhqgrAdvTT8861b38f.I+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DOPFKE+KnhqgrAdvTT8861b38f.I+20 Flags: Nonsymbolic FontBBox: -354, -218, 1385, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFJE+XrnmctAdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DOPFJE+XrnmctAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DOPGCD+RqxkndAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DOPGCD+RqxkndAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPEPA+KppchjAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: DOPEPA+KppchjAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFAB+JkrprqAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DOPFAB+JkrprqAdvTT8861b38f.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPENP+MnmlxfAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DOPENP+MnmlxfAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPEOP+KcgxhkAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DOPEOP+KcgxhkAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFLF+SjtxsjAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: DOPFLF+SjtxsjAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DOPAFE+NsthrkAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DOPAFE+NsthrkAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPDDD+JlnscrAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DOPDDD+JlnscrAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DOPDEF+HsfdklAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: DOPDEF+HsfdklAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPDDE+RyvlndAdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: DOPDDE+RyvlndAdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFBC+FxmjnpAdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DOPFBC+FxmjnpAdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: DOPDKD+VwskngAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DOPDKD+VwskngAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFBD+TwxsfnAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: DOPFBD+TwxsfnAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPEJO+TbyhhdAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: DOPEJO+TbyhhdAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFED+XvhwkcAdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DOPFED+XvhwkcAdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DOPFEE+RlyjhkAdvTT43ccf47d FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DOPFEE+RlyjhkAdvTT43ccf47d Flags: Serif, Nonsymbolic FontBBox: -20, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: Clinical practice guidelines,Practice guidelines,Recommendations,Quality of health care,AGREE tool,Implementability Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13012-020-01036-5 Implementation Science Implementation Science, 2020, doi:10.1186/s13012-020-01036-5 Clinical practice guidelines Practice guidelines Recommendations Quality of health care AGREE tool Implementability Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation–Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement Ivan D. Florez Melissa C. Brouwers Kate Kerkvliet Karen Spithoff Pablo Alonso-Coello Jako Burgers Francoise Cluzeau Beatrice Férvers Ian Graham Jeremy Grimshaw Steven Hanna Monika Kastner Michelle Kho Amir Qaseem Sharon Straus 2020-09-18T13:19:20+02:00 2020-09-18T13:19:20+02:00 2020-09-16T10:20:32+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:9998fa4f-10a0-4b2b-ae1a-8c9d5335fb32 uuid:3d575565-de43-408a-838d-e8fa6c8d1d6a default 1 converted uuid:9998fa4f-10a0-4b2b-ae1a-8c9d5335fb32 converted to PDF/A-2b pdfToolbox 2020-09-16T21:44:43+08:00 2 B Ivan D. Florez http://orcid.org/0000-0002-0751-8932 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 469, 133, 478 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 183, 186, 190 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 104, 93, 109, 103 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 115, 93, 120, 103 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 173, 69, 178, 79 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 69, 188, 79 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 193, 69, 198, 79 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 391, 481, 396, 491 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 402, 481, 407, 491 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 454, 421, 459, 431 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 448, 373, 453, 383 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 458, 373, 468, 383 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 505, 227, 510, 237 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 56, 597, 135, 606 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 101, 500, 111, 509 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 405, 657, 410, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 441, 533, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 497, 237, 502, 246 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 141, 489, 146, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 189, 91, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 112, 189, 117, 198 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 102, 561, 107, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 138, 489, 216, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 147, 452, 152, 461 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 384, 345, 389, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 358, 321, 363, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 378, 225, 383, 234 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 59, 381, 69, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 234, 309, 244, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 105, 285, 115, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 211, 261, 216, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 177, 285, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 657, 533, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 573, 531, 582 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 230, 684, 284, 692 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 675, 133, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 256, 246, 274, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 237, 140, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 501, 513, 532, 521 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 504, 376, 512 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 391, 306, 466, 314 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 04950154 Type: CRC32 Checksum: 513889821e6db4dd7e3ad3fa7e2a5f34 Type: MD5 Checksum: 89b1aa660b4b51c47ad20886388332a80d849eff Type: SHA-1