6e6d23ab51ac10bbcde4d7c747f73b4f  284156.pdf
df517508d57839252cf43a8fa6faa7deeec1de3a  284156.pdf
7db42217868de3d15c21dbcca1e385a47d30a07dd130d676c6f64a48c1fff8ea  284156.pdf

Title:          Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells
Subject:        Stem Cell Research, 47 (2020) 101899. doi:10.1016/j.scr.2020.101899
Keywords:       Mesenchymal stem cells; Integrin alpha 6; Clonogenicity; Proliferation; Protein kinase B; Migration; 
Author:         Nuria Nieto-Nicolau
Creator:        Elsevier
CreationDate:   Wed Aug 26 15:22:57 2020 CEST
ModDate:        Wed Aug 26 15:22:57 2020 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      5434142 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XVQCBU+CharisSIL                     CID Type 0C       Identity-H       yes yes yes    567  0
BCMGBL+AdvOT596495f2                 Type 1C           WinAnsi          yes yes no     541  0
BCMGDL+AdvOT0de51fd2                 Type 1C           WinAnsi          yes yes no     542  0
BCMGDM+AdvOT596495f2+03              Type 1C           Custom           yes yes yes    543  0
BCMGDN+AdvOT8608a8d1+20              Type 1C           Custom           yes yes yes    553  0
BCMGDO+AdvOT7fb33346.I               Type 1C           WinAnsi          yes yes no     554  0
BCMGDP+AdvOT596495f2+fb              Type 1C           Custom           yes yes yes    555  0
BCMGFA+AdvOT1efcda3b.B               Type 1C           WinAnsi          yes yes no     562  0
BCMGFB+AdvOT596495f2+20              Type 1C           Custom           yes yes yes    568  0
XVQCBU+CharisSIL-Italic              CID Type 0C       Identity-H       yes yes yes    203  0
BCMGGB+AdvOT596495f2+21              Type 1C           WinAnsi          yes yes no     200  0
BCMGGC+AdvOT7fb33346.I+fb            Type 1C           Custom           yes yes yes    195  0
BCMGID+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    215  0
BCNBEC+AdvOT596495f2+22              Type 1C           Custom           yes yes no     216  0
BCNIDI+AdvOT7fb33346.I+03            Type 1C           Custom           yes yes yes    217  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-11-07 02:42:20 CET
 RepresentationInformation: 284156.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-11-06 11:11:59 CET
  Size: 5434142
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0150' cannot be found
   Offset: 5402056
  ID: PDF-HUL-128
  InfoMessage: Outlines contain recursive references.
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 637
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
        Children: 
         Item: 
          Title: Ethical considerations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: Isolation and culture of cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: Spheroid and spheroid-derived MSC generation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
         Item: 
          Title: Multilineage differentiation experiments
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: Flow cytometry characterization and sorting
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: Colony forming efficiency assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: Adhesion assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: Migration assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
         Item: 
          Title: Proliferation assay
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
         Item: 
          Title: Small interfering mRNA transfection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
         Item: 
          Title: Immunofluorescence and confocal microscopy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
         Item: 
          Title: Western blot analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
         Item: 
          Title: Extraction of mRNA and quantitative polymerase chain reaction
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
        Children: 
         Item: 
          Title: ITGA6 was related to higher clonogenicity and migration but was lost with culture passages
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
         Item: 
          Title: MSC could retain mesenchymal phenotype although showed impaired clonogenicity or migration
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
         Item: 
          Title: ITGA6 selected smaller BM-MSC with greater proliferation, clonogenicity and differentiation potentials
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
         Item: 
          Title: Culture confluence regulated ITGA6 affecting proliferation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
         Item: 
          Title: Fibronectin enhanced more ITGA6 expression and CFE than laminin-111 at low densities
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207
         Item: 
          Title: Fibronectin improved more proliferation than laminin-111 activating AKT pathway
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d
         Item: 
          Title: Laminin-111 was more specific for ITGA6 binding although fibronectin enhanced the expression of growth factors
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d
         Item: 
          Title: Ethical considerations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f
       Item: 
        Title: Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468
       Item: 
        Title: CRediT authorship contribution statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765
       Item: 
        Title: Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8
   Info: 
    Title: Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells
    Author: Nuria Nieto-Nicolau
    Subject: Stem Cell Research, 47 (2020) 101899. doi:10.1016/j.scr.2020.101899
    Keywords: Mesenchymal stem cells; Integrin alpha 6; Clonogenicity; Proliferation; Protein kinase B; Migration; 
    Creator: Elsevier
    CreationDate: Wed Aug 26 15:22:57 CEST 2020
    ModDate: Wed Aug 26 15:22:57 CEST 2020
   ID: 0x4028d1d4e99985d41a3832131875d96c, 0x12992ea367020345b2fa56bb12f9ff0b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 272
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2042
      ImageHeight: 2281
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2070
      ImageHeight: 2628
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2010
      ImageHeight: 2507
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2070
      ImageHeight: 2654
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2069
      ImageHeight: 1863
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2070
      ImageHeight: 1501
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2070
      ImageHeight: 2051
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: XVQCBU+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: XVQCBU+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: BCMGGC+AdvOT7fb33346.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: BCMGGC+AdvOT7fb33346.I+fb
       Flags: Symbolic
       FontBBox: -130, -229, 907, 878
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCMGGB+AdvOT596495f2+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: BCMGGB+AdvOT596495f2+21
       Flags: Nonsymbolic
       FontBBox: 0, -229, 1623, 878
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BCMGDN+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BCMGDN+AdvOT8608a8d1+20
       Flags: Symbolic
       FontBBox: -970, -341, 2000, 1023
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCMGDO+AdvOT7fb33346.I
      FontSubset: true
      FirstChar: 38
      LastChar: 122
      FontDescriptor: 
       FontName: BCMGDO+AdvOT7fb33346.I
       Flags: Serif, Nonsymbolic
       FontBBox: -160, -257, 1000, 980
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BCMGDP+AdvOT596495f2+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: BCMGDP+AdvOT596495f2+fb
       Flags: Symbolic
       FontBBox: 27, 0, 921, 878
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCMGFA+AdvOT1efcda3b.B
      FontSubset: true
      FirstChar: 45
      LastChar: 241
      FontDescriptor: 
       FontName: BCMGFA+AdvOT1efcda3b.B
       Flags: Nonsymbolic
       FontBBox: -89, -257, 956, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BCMGID+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BCMGID+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -480, -367, 864, 928
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCMGFB+AdvOT596495f2+20
      FontSubset: true
      FirstChar: 2
      LastChar: 150
      FontDescriptor: 
       FontName: BCMGFB+AdvOT596495f2+20
       Flags: Symbolic
       FontBBox: -477, -355, 1103, 878
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCNBEC+AdvOT596495f2+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: BCNBEC+AdvOT596495f2+22
       Flags: Nonsymbolic
       FontBBox: 4, -257, 884, 878
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: BCNIDI+AdvOT7fb33346.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: BCNIDI+AdvOT7fb33346.I+03
       Flags: Symbolic
       FontBBox: -716, -533, 832, 1008
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCMGBL+AdvOT596495f2
      FontSubset: true
      FirstChar: 35
      LastChar: 252
      FontDescriptor: 
       FontName: BCMGBL+AdvOT596495f2
       Flags: Serif, Nonsymbolic
       FontBBox: -79, -257, 920, 984
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BCMGDL+AdvOT0de51fd2
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: BCMGDL+AdvOT0de51fd2
       Flags: Nonsymbolic
       FontBBox: -13, -250, 992, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BCMGDM+AdvOT596495f2+03
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: BCMGDM+AdvOT596495f2+03
       Flags: Symbolic
       FontBBox: -677, -533, 832, 1008
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
    CIDFontType0: 
     Font: 
      BaseFont: XVQCBU+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XVQCBU+CharisSIL
       Flags: Serif, Symbolic
       FontBBox: -692, -533, 3000, 1270
       FontFile3: true
     Font: 
      BaseFont: XVQCBU+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XVQCBU+CharisSIL-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -716, -533, 3058, 1270
       FontFile3: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.139439, 2010/09/27-13:37:26        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.scr.2020.101899</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Nuria Nieto-Nicolau</rdf:li>
               <rdf:li>Raquel M. de la Torre</rdf:li>
               <rdf:li>Oscar Fariñas</rdf:li>
               <rdf:li>Andrés Savio</rdf:li>
               <rdf:li>Anna Vilarrodona</rdf:li>
               <rdf:li>Ricardo P. Casaroli-Marano</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Mesenchymal stem cells</rdf:li>
               <rdf:li>Integrin alpha 6</rdf:li>
               <rdf:li>Clonogenicity</rdf:li>
               <rdf:li>Proliferation</rdf:li>
               <rdf:li>Protein kinase B</rdf:li>
               <rdf:li>Migration</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Stem Cell Research, 47 (2020) 101899. doi:10.1016/j.scr.2020.101899</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Stem Cell Research</prism:publicationName>
         <prism:copyright>© 2020 The Author(s). Published by Elsevier B.V.</prism:copyright>
         <prism:issn>1873-5061</prism:issn>
         <prism:volume>47</prism:volume>
         <prism:coverDisplayDate>August 2020</prism:coverDisplayDate>
         <prism:pageRange>101899</prism:pageRange>
         <prism:startingPage>101899</prism:startingPage>
         <prism:doi>10.1016/j.scr.2020.101899</prism:doi>
         <prism:url>https://doi.org/10.1016/j.scr.2020.101899</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.scr.2020.101899</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <DpairmweQnd6OmteGodr8msNNotaQlt_8mPmGzt-RnMuOywyJnPr9o9ePot-Ln9qSmMqTma/>
         <pdfx:doi>10.1016/j.scr.2020.101899</pdfx:doi>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2020-08-26T13:22:57Z</xmp:ModifyDate>
         <xmp:CreateDate>2020-08-26T13:22:57Z</xmp:CreateDate>
         <xmp:MetadataDate>2020-08-26T13:22:57Z</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>Mesenchymal stem cells; Integrin alpha 6; Clonogenicity; Proliferation; Protein kinase B; Migration; </pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:d38b8583-22ac-4255-9278-4af251c94c31</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:faea93c1-857e-48d7-9264-e23c51ba5797</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/BY-NC-ND/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 322, 723, 369, 731
      Annotation: 
       Subtype: Link
       Rect: 280, 668, 399, 676
      Annotation: 
       Subtype: Link
       Rect: 37, 730, 37, 742
      Annotation: 
       Subtype: Link
       Rect: 132, 580, 136, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 138, 580, 142, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 145, 580, 149, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 259, 580, 264, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 334, 580, 338, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 340, 580, 345, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 413, 580, 417, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 419, 580, 423, 591
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 121, 567, 125, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 127, 567, 132, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 267, 567, 271, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 274, 567, 278, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 280, 567, 284, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 286, 567, 291, 578
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 293, 568, 297, 579
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 101, 250, 158, 258
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 40, 198, 115, 206
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 190, 177, 267, 185
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 448, 281, 521, 289
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 309, 250, 373, 258
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 415, 240, 557, 248
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 306, 229, 348, 237
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 37, 75, 176, 82
      Annotation: 
       Subtype: Link
       Rect: 97, 92, 153, 99
      Annotation: 
       Subtype: Link
       Rect: 231, 747, 375, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 605, 536, 623
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 695, 119, 703
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 220, 684, 283, 692
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 197, 653, 288, 661
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 37, 642, 55, 650
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 269, 642, 288, 650
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 37, 632, 96, 640
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 154, 632, 267, 640
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 182, 193, 249, 201
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 173, 88, 283, 96
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 267, 78, 288, 86
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 37, 67, 120, 75
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 309, 580, 377, 588
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 309, 506, 380, 514
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 520, 276, 552, 284
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 435, 224, 508, 232
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 477, 182, 507, 190
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 306, 140, 538, 148
      Annotation: 
       Subtype: Link
       Rect: 306, 130, 345, 138
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 726, 179, 734
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 244, 580, 274, 588
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 202, 559, 233, 567
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 338, 684, 369, 692
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 501, 642, 557, 650
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 306, 632, 348, 640
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 525, 590, 557, 598
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 306, 580, 324, 588
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 398, 391, 429, 399
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 483, 318, 557, 326
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 306, 308, 353, 316
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 350, 140, 371, 148
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 343, 109, 364, 117
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 528, 67, 552, 75
       Destination: null
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 101, 149, 109
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 429, 101, 450, 109
       Destination: 37
    Page: 
     Label: 5
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 40, 569, 60, 577
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 152, 506, 183, 514
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 135, 396, 154, 404
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 89, 375, 109, 383
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 214, 365, 235, 373
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 40, 334, 60, 342
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 40, 172, 60, 180
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 257, 140, 278, 148
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 147, 119, 169, 127
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 194, 88, 214, 96
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 212, 78, 232, 86
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 353, 632, 373, 640
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 512, 621, 533, 629
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 330, 590, 351, 598
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 381, 558, 402, 566
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 356, 537, 376, 545
       Destination: 78
      Annotation: 
       Subtype: Link
       Rect: 410, 430, 431, 437
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 309, 419, 329, 427
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 340, 388, 360, 396
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 453, 367, 479, 375
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 462, 325, 486, 333
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 309, 206, 330, 214
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 392, 196, 413, 204
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 511, 144, 531, 152
       Destination: 97
    Page: 
     Label: 7
    Page: 
     Label: 8
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 631, 122, 639
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 221, 599, 241, 607
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 197, 578, 217, 586
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 380, 631, 402, 639
       Destination: 97
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 95, 226, 288, 234
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 37, 216, 55, 224
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 197, 205, 288, 213
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 37, 195, 101, 203
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 156, 174, 177, 182
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 87, 153, 108, 161
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 257, 142, 278, 150
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 106, 90, 126, 98
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 376, 257, 396, 265
       Destination: 116
      Annotation: 
       Subtype: Link
       Rect: 418, 151, 524, 159
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 436, 140, 519, 148
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 463, 88, 557, 96
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 306, 78, 324, 86
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 332, 46, 395, 54
       Destination: 123
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 74, 134, 82
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 138, 53, 218, 61
       Destination: 156
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 580, 113, 588
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 107, 569, 191, 577
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 171, 538, 288, 546
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 37, 527, 212, 535
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 178, 485, 257, 493
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 40, 454, 104, 462
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 40, 412, 101, 420
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 215, 402, 270, 410
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 76, 350, 140, 357
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 132, 329, 184, 337
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 73, 287, 123, 295
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 253, 255, 288, 263
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 37, 245, 79, 253
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 529, 493, 557, 501
      Annotation: 
       Subtype: Link
       Rect: 306, 483, 432, 491
      Annotation: 
       Subtype: Link
       Rect: 397, 426, 518, 432
      Annotation: 
       Subtype: Link
       Rect: 521, 402, 554, 408
      Annotation: 
       Subtype: Link
       Rect: 318, 394, 386, 400
      Annotation: 
       Subtype: Link
       Rect: 481, 354, 553, 360
      Annotation: 
       Subtype: Link
       Rect: 318, 346, 365, 352
      Annotation: 
       Subtype: Link
       Rect: 485, 322, 557, 328
      Annotation: 
       Subtype: Link
       Rect: 318, 314, 366, 320
      Annotation: 
       Subtype: Link
       Rect: 448, 282, 556, 289
      Annotation: 
       Subtype: Link
       Rect: 318, 274, 357, 281
      Annotation: 
       Subtype: Link
       Rect: 473, 242, 544, 249
      Annotation: 
       Subtype: Link
       Rect: 318, 234, 379, 241
      Annotation: 
       Subtype: Link
       Rect: 412, 210, 525, 217
      Annotation: 
       Subtype: Link
       Rect: 512, 187, 557, 193
      Annotation: 
       Subtype: Link
       Rect: 318, 179, 395, 185
      Annotation: 
       Subtype: Link
       Rect: 318, 147, 429, 153
      Annotation: 
       Subtype: Link
       Rect: 354, 115, 488, 121
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 384, 288, 390
      Annotation: 
       Subtype: Link
       Rect: 49, 376, 157, 382
      Annotation: 
       Subtype: Link
       Rect: 170, 344, 286, 350
      Annotation: 
       Subtype: Link
       Rect: 49, 336, 63, 342
      Annotation: 
       Subtype: Link
       Rect: 243, 320, 288, 326
      Annotation: 
       Subtype: Link
       Rect: 49, 312, 117, 318
      Annotation: 
       Subtype: Link
       Rect: 103, 280, 223, 287
      Annotation: 
       Subtype: Link
       Rect: 78, 248, 215, 255
      Annotation: 
       Subtype: Link
       Rect: 186, 232, 286, 239
      Annotation: 
       Subtype: Link
       Rect: 226, 208, 280, 215
      Annotation: 
       Subtype: Link
       Rect: 49, 200, 96, 207
      Annotation: 
       Subtype: Link
       Rect: 78, 169, 186, 175
      Annotation: 
       Subtype: Link
       Rect: 401, 703, 524, 709
      Annotation: 
       Subtype: Link
       Rect: 524, 687, 557, 693
      Annotation: 
       Subtype: Link
       Rect: 318, 679, 398, 685
      Annotation: 
       Subtype: Link
       Rect: 358, 631, 457, 637
      Annotation: 
       Subtype: Link
       Rect: 512, 607, 557, 613
      Annotation: 
       Subtype: Link
       Rect: 318, 599, 386, 605
      Annotation: 
       Subtype: Link
       Rect: 483, 575, 555, 581
      Annotation: 
       Subtype: Link
       Rect: 318, 567, 376, 573
      Annotation: 
       Subtype: Link
       Rect: 446, 543, 557, 550
      Annotation: 
       Subtype: Link
       Rect: 318, 535, 363, 542
      Annotation: 
       Subtype: Link
       Rect: 354, 503, 484, 510
      Annotation: 
       Subtype: Link
       Rect: 354, 487, 467, 494
      Annotation: 
       Subtype: Link
       Rect: 354, 463, 484, 470
      Annotation: 
       Subtype: Link
       Rect: 354, 432, 462, 438
      Annotation: 
       Subtype: Link
       Rect: 381, 400, 482, 406
      Annotation: 
       Subtype: Link
       Rect: 483, 376, 555, 382
      Annotation: 
       Subtype: Link
       Rect: 318, 368, 376, 374
      Annotation: 
       Subtype: Link
       Rect: 397, 352, 527, 358
      Annotation: 
       Subtype: Link
       Rect: 383, 328, 513, 334
      Annotation: 
       Subtype: Link
       Rect: 447, 288, 548, 295
      Annotation: 
       Subtype: Link
       Rect: 318, 256, 419, 263
      Annotation: 
       Subtype: Link
       Rect: 408, 232, 535, 239
      Annotation: 
       Subtype: Link
       Rect: 494, 208, 549, 215
      Annotation: 
       Subtype: Link
       Rect: 318, 200, 412, 207
      Annotation: 
       Subtype: Link
       Rect: 449, 177, 547, 183
  Checksum: b74f3f23
   Type: CRC32
  Checksum: 6e6d23ab51ac10bbcde4d7c747f73b4f
   Type: MD5
  Checksum: df517508d57839252cf43a8fa6faa7deeec1de3a
   Type: SHA-1