a863ebf963042b0dfa25308d762b0c82 284157.pdf 6ebd4527ae32fa12c92d86c3ffae22210224ce24 284157.pdf a899178063dc6544cc5ed768a59b191a558e3f2a014a17da143cf5fd6e470468 284157.pdf Title: Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells Subject: Cellular and Molecular Life Sciences, https://doi.org/10.1007/s00018-019-03330-y Keywords: Cholesterol,Late endosomes,Rab7,NPC1,Annexin A6,Membrane contact sites Author: Elsa Meneses-Salas Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Thu Oct 24 11:51:48 2019 CEST ModDate: Thu Jun 25 10:23:36 2020 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 11509294 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C Custom yes no yes 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(2019-04-17) LastModified: 2023-11-06 11:24:37 CET Size: 11509294 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 977 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Annexin A6 modulates TBC1D15Rab7StARD3 axis to control endosomal cholesterol export in NPC1 cells Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Materials Item: Title: Cell culture and transfections Item: Title: Generation of CHO M12-A6ko cells using the CRISPRCas9 system Item: Title: Immunoblotting Item: Title: RNA extraction and quantitative real-time PCR Item: Title: Preparation of liver homogenates Item: Title: Immunoprecipitation Item: Title: Pull-down assays Item: Title: Subcellular fractionation Item: Title: Immunofluorescence Item: Title: LDL-cholesterol transport studies Item: Title: Live-cell LDL-BODIPY-cholesteryl linoleate transport assay Item: Title: Image analysis Item: Title: Electron microscopy Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Interaction of AnxA6 with the Rab7-GAP TBC1D15 Item: Title: AnxA6 interferes with Rab7 activity to impair late endosome-cholesterol egress Item: Title: AnxA6 depletion restores cholesterol trafficking in NPC1 mutant cells Item: Title: StARD3 is required to rescue late endosome-cholesterol export in NPC1 mutant cells lacking AnxA6 Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 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https://doi.org/10.1007/s00018-019-03330-y Springer International Publishing Cellular and Molecular Life Sciences, https://doi.org/10.1007/s00018-019-03330-y Cholesterol Late endosomes Rab7 NPC1 Annexin A6 Membrane contact sites Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells Elsa Meneses-Salas Ana García-Melero Kristiina Kanerva Patricia Blanco-Muñoz Frederic Morales-Paytuvi Júlia Bonjoch Josefina Casas Antonia Egert Syed S. Beevi Jaimy Jose Vicenta Llorente-Cortés Kerry-Anne Rye Joerg Heeren Albert Lu Albert Pol Francesc Tebar Elina Ikonen Thomas Grewal Carlos Enrich Carles Rentero 10.1007/s00018-019-03330-y 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00018-019-03330-y 10.1007/s00018-019-03330-y 1420-9071 77 14 2839 2857 journal Cellular and Molecular Life Sciences The Author(s) 2010-04-23 true 10.1007/s00018-019-03330-y noindex springer.com springerlink.com VoR uuid:8a35905d-7945-4896-8ef5-86fedc493dc4 uuid:9cd4742f-05a5-4937-bd54-a8bf7f2925ef default 1 converted uuid:e096d2da-20fc-4c8f-8bcd-3b7498a9752e converted to PDF/A-2b pdfToolbox 2020-06-25T13:52:37+05:30 2 B Thomas Grewal http://orcid.org/0000-0002-7937-8887 Carlos Enrich http://orcid.org/0000-0003-0382-2993 Carles Rentero http://orcid.org/0000-0003-4684-0278 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. 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