398a35e2a0ff725176a273dbc7869aed 284410.pdf dba1698dc5a8d56f66ba9f50ab01b9dfa6d44798 284410.pdf 1db3f3a3ff2d3300655d3fccb0631911229d05a0a700d3625b8ddb2e3cadd8f8 284410.pdf Title: ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients Subject: Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Keywords: ABCB1, P-glycoprotein, irinotecan (CPT-11), gastrointestinal toxicity, diarrhea, mucositis, biomarker, colorectal cancer Author: Pau Riera Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Sat Jun 27 02:07:28 2020 CEST ModDate: Sat Jun 27 02:52:41 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 480028 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IPAKPJ+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 574 0 IPAKPK+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 575 0 IPAKPL+AdvOT01861455.I Type 1C WinAnsi yes yes no 576 0 IPAKPM+AdvOT01861455.I+20 Type 1C WinAnsi yes yes no 577 0 IPAKPN+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 578 0 IPAKPO+AdvPSA18C Type 1C WinAnsi yes yes no 579 0 IPALAO+AdvOT1deab444.I Type 1C WinAnsi yes yes no 580 0 IPALAP+AdvPSA323 Type 1C WinAnsi yes yes no 581 0 IPALBA+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 582 0 IPALBB+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 583 0 IPALDB+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 592 0 IPALJA+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 210 0 IPALJB+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 207 0 IPALJC+AdvOTd877c31c+20 Type 1C Custom yes yes yes 208 0 IPALJD+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 181 0 IPALJE+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 184 0 IPALJF+AdvTT58d178b9+03 Type 1C Custom yes yes yes 187 0 IPALJG+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 192 0 IPALJH+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 199 0 IPALKI+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 197 0 IPALLI+AdvOTf94803d4 Type 1C WinAnsi yes yes no 216 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 212 0 IPAMDH+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 220 0 IPAMDI+AdvOT6e5d2ec0+22 Type 1C Custom yes yes yes 215 0 IPAMDJ+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 217 0 IPAMDK+AdvTTf90d833a.I+20 Type 1C Custom yes yes yes 213 0 IPAMGK+AdvOT1deab444.I+22 Type 1C Custom yes yes no 223 0 IPAMIK+AdvOT34fe1490.B+22 Type 1C Custom yes yes no 224 0 IPAMKK+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 225 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-10 02:35:37 CET RepresentationInformation: 284410.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-09 12:25:59 CET Size: 480028 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B19' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B26' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B22' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B20' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 454110 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 454110 MIMEtype: application/pdf PDFMetadata: Objects: 655 FreeObjects: 3 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: Patient Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Genetic Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: Associations Between ABCB1 Variants and Severe Side Effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Associations Between ABCB1 Haplotypes and Severe Side Effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients Author: Pau Riera Subject: Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Keywords: ABCB1, P-glycoprotein, irinotecan (CPT-11), gastrointestinal toxicity, diarrhea, mucositis, biomarker, colorectal cancer Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Sat Jun 27 02:07:28 CEST 2020 ModDate: Sat Jun 27 02:52:41 CEST 2020 ID: 0x35c873ea2daad0e136d639300f3ad668, 0x94120809910568449b84a1a5a4afd0d9 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1417 ImageHeight: 525 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: IPAKPL+AdvOT01861455.I FontSubset: true FirstChar: 42 LastChar: 122 FontDescriptor: FontName: IPAKPL+AdvOT01861455.I Flags: Nonsymbolic FontBBox: -125, -208, 1000, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALJG+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: IPALJG+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPAKPM+AdvOT01861455.I+20 FontSubset: true FirstChar: 134 LastChar: 134 FontDescriptor: FontName: IPAKPM+AdvOT01861455.I+20 Flags: Nonsymbolic FontBBox: -156, -156, 1010, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPAKPN+AdvOT01861455.I+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: IPAKPN+AdvOT01861455.I+01 Flags: Nonsymbolic FontBBox: -41, -166, 1125, 927 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: IPAKPO+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IPAKPO+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALAO+AdvOT1deab444.I FontSubset: true FirstChar: 40 LastChar: 241 FontDescriptor: FontName: IPALAO+AdvOT1deab444.I Flags: Nonsymbolic FontBBox: -135, -208, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALAP+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: IPALAP+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALKI+AdvOTb65e897d.B FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: IPALKI+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALBA+AdvOT6e5d2ec0 FontSubset: true FirstChar: 37 LastChar: 124 FontDescriptor: FontName: IPALBA+AdvOT6e5d2ec0 Flags: Nonsymbolic FontBBox: -62, -208, 895, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALBB+AdvOT6e5d2ec0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IPALBB+AdvOT6e5d2ec0+fb Flags: Symbolic FontBBox: 0, 0, 500, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPALJH+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: IPALJH+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALJB+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IPALJB+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPALDB+AdvOT1deab444.I+20 FontSubset: true FirstChar: 134 LastChar: 134 FontDescriptor: FontName: IPALDB+AdvOT1deab444.I+20 Flags: Nonsymbolic FontBBox: -156, -145, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALJC+AdvOTd877c31c+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IPALJC+AdvOTd877c31c+20 Flags: Symbolic FontBBox: -177, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPALJA+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: IPALJA+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HelveticaNeueLTStd-Bd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPAMDK+AdvTTf90d833a.I+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IPAMDK+AdvTTf90d833a.I+20 Flags: Symbolic FontBBox: -208, -208, 1020, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPAMDI+AdvOT6e5d2ec0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IPAMDI+AdvOT6e5d2ec0+22 Flags: Symbolic FontBBox: -156, -145, 718, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPALLI+AdvOTf94803d4 FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: IPALLI+AdvOTf94803d4 Flags: Nonsymbolic FontBBox: -41, -218, 937, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPAMDJ+AdvOT1deab444.I+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IPAMDJ+AdvOT1deab444.I+fb Flags: Symbolic FontBBox: 9, 0, 572, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPAMDH+AdvOT6e5d2ec0+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: IPAMDH+AdvOT6e5d2ec0+20 Flags: Nonsymbolic FontBBox: -156, -145, 1041, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPAMGK+AdvOT1deab444.I+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: IPAMGK+AdvOT1deab444.I+22 Flags: Nonsymbolic FontBBox: -156, -145, 739, 843 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IPAMIK+AdvOT34fe1490.B+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: IPAMIK+AdvOT34fe1490.B+22 Flags: Nonsymbolic FontBBox: -156, -166, 718, 864 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IPAMKK+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IPAMKK+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPALJD+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: IPALJD+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPALJE+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: IPALJE+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: IPALJF+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: IPALJF+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IPAKPJ+AdvOT6601a1b9.BI FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: IPAKPJ+AdvOT6601a1b9.BI Flags: Nonsymbolic FontBBox: -125, -208, 1020, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IPAKPK+AdvOT34fe1490.B FontSubset: true FirstChar: 37 LastChar: 183 FontDescriptor: FontName: IPAKPK+AdvOT34fe1490.B Flags: Nonsymbolic FontBBox: -52, -208, 937, 968 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 7.0 (Windows) ABCB1, P-glycoprotein, irinotecan (CPT-11), gastrointestinal toxicity, diarrhea, mucositis, biomarker, colorectal cancer 2020-06-27T08:52:41+08:00 2020-06-27T08:07:28+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2020-06-27T08:52:41+08:00 application/pdf ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients Pau Riera Alı´cia Artigas-Baleri Juliana Salazar Ana Sebio Anna C. Virgili Marı´a Jesu´ s Arranz David Pa´ ez Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. ABCB1 P-glycoprotein irinotecan (CPT-11) gastrointestinal toxicity diarrhea mucositis biomarker colorectal cancer uuid:52e31d8d-c2bd-484a-864b-d106cd44a2b6 uuid:476b895e-d2a7-40a5-b947-1a8f8789e78b Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 526, 447, 547 Annotation: Subtype: Link Rect: 175, 503, 499, 524 Annotation: Subtype: Link Rect: 175, 480, 496, 501 Annotation: Subtype: Link Rect: 175, 457, 420, 478 Annotation: Subtype: Link Rect: 175, 434, 335, 455 Annotation: Subtype: Link Rect: 175, 411, 216, 420 Annotation: Subtype: Link Rect: 336, 411, 398, 420 Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 448, 158, 456 Annotation: Subtype: Link Rect: 96, 299, 158, 306 Annotation: Subtype: Link Rect: 64, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 475, 728, 549, 735 Annotation: Subtype: Link Rect: 455, 720, 549, 727 Annotation: Subtype: Link Rect: 45, 719, 169, 753 Annotation: Subtype: Link Rect: 521, 678, 549, 706 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 267, 640, 289, 649 Destination: 122 Annotation: Subtype: Link Rect: 45, 628, 84, 638 Destination: 122 Annotation: Subtype: Link Rect: 48, 536, 112, 546 Destination: 122 Annotation: Subtype: Link Rect: 206, 525, 287, 534 Destination: null Annotation: Subtype: Link Rect: 45, 513, 131, 523 Destination: null Annotation: Subtype: Link Rect: 137, 513, 209, 523 Destination: null Annotation: Subtype: Link Rect: 216, 513, 283, 523 Destination: null Annotation: Subtype: Link Rect: 97, 410, 155, 419 Destination: null Annotation: Subtype: Link Rect: 160, 410, 245, 419 Destination: null Annotation: Subtype: Link Rect: 249, 410, 289, 419 Destination: null Annotation: Subtype: Link Rect: 45, 398, 63, 408 Destination: null Annotation: Subtype: Link Rect: 68, 398, 140, 408 Destination: 122 Annotation: Subtype: Link Rect: 145, 398, 197, 408 Destination: null Annotation: Subtype: Link Rect: 249, 375, 289, 385 Destination: null Annotation: Subtype: Link Rect: 45, 364, 87, 373 Destination: null Annotation: Subtype: Link Rect: 93, 364, 175, 373 Destination: null Annotation: Subtype: Link Rect: 186, 352, 272, 362 Destination: null Annotation: Subtype: Link Rect: 278, 352, 289, 362 Destination: null Annotation: Subtype: Link Rect: 45, 341, 83, 350 Destination: null Annotation: Subtype: Link Rect: 223, 329, 287, 339 Destination: null Annotation: Subtype: Link Rect: 45, 318, 120, 327 Destination: null Annotation: Subtype: Link Rect: 124, 318, 199, 327 Destination: 122 Annotation: Subtype: Link Rect: 203, 318, 257, 327 Destination: null Annotation: Subtype: Link Rect: 261, 318, 289, 327 Destination: null Annotation: Subtype: Link Rect: 45, 306, 63, 316 Destination: null Annotation: Subtype: Link Rect: 67, 306, 170, 316 Destination: null Annotation: Subtype: Link Rect: 351, 559, 422, 568 Destination: null Annotation: Subtype: Link Rect: 309, 398, 486, 408 Destination: 122 Annotation: Subtype: Link Rect: 372, 98, 457, 108 Destination: null Annotation: Subtype: Link Rect: 462, 98, 526, 108 Destination: null Annotation: Subtype: Link Rect: 478, 75, 544, 85 Destination: null Annotation: Subtype: Link Rect: 306, 64, 338, 73 Destination: 42 Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 143, 708, 233, 717 Destination: 122 Annotation: Subtype: Link Rect: 120, 616, 289, 626 Destination: 122 Annotation: Subtype: Link Rect: 45, 605, 63, 614 Destination: 122 Annotation: Subtype: Link Rect: 499, 662, 532, 671 Destination: 42 Annotation: Subtype: Link Rect: 390, 627, 418, 637 Destination: 71 Annotation: Subtype: Link Rect: 420, 345, 509, 355 Destination: 122 Annotation: Subtype: Link Rect: 503, 288, 533, 297 Destination: 103 Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 45, 352, 75, 362 Destination: 103 Annotation: Subtype: Link Rect: 136, 168, 221, 178 Destination: 122 Annotation: Subtype: Link Rect: 251, 134, 289, 143 Destination: null Annotation: Subtype: Link Rect: 45, 122, 289, 132 Destination: null Annotation: Subtype: Link Rect: 45, 111, 157, 120 Destination: null Annotation: Subtype: Link Rect: 514, 410, 549, 419 Destination: null Annotation: Subtype: Link Rect: 306, 398, 345, 408 Destination: null Annotation: Subtype: Link Rect: 349, 398, 411, 408 Destination: 122 Annotation: Subtype: Link Rect: 415, 398, 472, 408 Destination: null Annotation: Subtype: Link Rect: 346, 364, 409, 373 Destination: null Annotation: Subtype: Link Rect: 443, 329, 528, 339 Destination: null Annotation: Subtype: Link Rect: 533, 329, 549, 339 Destination: null Annotation: Subtype: Link Rect: 306, 318, 346, 327 Destination: null Annotation: Subtype: Link Rect: 350, 318, 401, 327 Destination: null Annotation: Subtype: Link Rect: 522, 272, 549, 281 Destination: null Annotation: Subtype: Link Rect: 306, 260, 348, 270 Destination: null Annotation: Subtype: Link Rect: 395, 203, 504, 212 Destination: null Annotation: Subtype: Link Rect: 446, 168, 525, 178 Destination: 122 Annotation: Subtype: Link Rect: 529, 168, 549, 178 Destination: 122 Annotation: Subtype: Link Rect: 306, 157, 344, 166 Destination: 122 Annotation: Subtype: Link Rect: 349, 157, 404, 166 Destination: null Annotation: Subtype: Link Rect: 408, 157, 464, 166 Destination: null Annotation: Subtype: Link Rect: 508, 111, 549, 120 Destination: null Annotation: Subtype: Link Rect: 306, 99, 323, 109 Destination: null Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 278, 404, 289, 414 Destination: 122 Annotation: Subtype: Link Rect: 45, 392, 113, 402 Destination: 122 Annotation: Subtype: Link Rect: 118, 392, 182, 402 Destination: 122 Annotation: Subtype: Link Rect: 187, 392, 246, 402 Destination: null Annotation: Subtype: Link Rect: 251, 392, 289, 402 Destination: null Annotation: Subtype: Link Rect: 45, 381, 63, 391 Destination: null Annotation: Subtype: Link Rect: 68, 381, 175, 391 Destination: null Annotation: Subtype: Link Rect: 227, 335, 289, 344 Destination: 122 Annotation: Subtype: Link Rect: 45, 324, 65, 333 Destination: 122 Annotation: Subtype: Link Rect: 224, 209, 289, 218 Destination: null Annotation: Subtype: Link Rect: 45, 197, 63, 206 Destination: null Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 318, 557, 549, 566 Annotation: Subtype: Link Rect: 306, 545, 411, 554 Annotation: Subtype: Link Rect: 181, 474, 244, 482 Annotation: Subtype: Link Rect: 105, 436, 203, 444 Annotation: Subtype: Link Rect: 114, 398, 212, 406 Annotation: Subtype: Link Rect: 163, 360, 246, 368 Annotation: Subtype: Link Rect: 120, 322, 213, 330 Annotation: Subtype: Link Rect: 263, 284, 289, 292 Annotation: Subtype: Link Rect: 55, 275, 126, 282 Annotation: Subtype: Link Rect: 261, 246, 289, 254 Annotation: Subtype: Link Rect: 55, 237, 108, 244 Annotation: Subtype: Link Rect: 263, 208, 289, 216 Annotation: Subtype: Link Rect: 55, 199, 105, 206 Annotation: Subtype: Link Rect: 68, 161, 124, 168 Annotation: Subtype: Link Rect: 169, 123, 236, 130 Annotation: Subtype: Link Rect: 198, 85, 256, 92 Annotation: Subtype: Link Rect: 344, 503, 434, 510 Annotation: Subtype: Link Rect: 366, 455, 439, 463 Annotation: Subtype: Link Rect: 329, 417, 405, 425 Annotation: Subtype: Link Rect: 523, 389, 549, 396 Annotation: Subtype: Link Rect: 316, 379, 369, 387 Annotation: Subtype: Link Rect: 329, 322, 412, 330 Annotation: Subtype: Link Rect: 329, 284, 388, 292 Annotation: Subtype: Link Rect: 524, 256, 549, 263 Annotation: Subtype: Link Rect: 316, 246, 357, 254 Annotation: Subtype: Link Rect: 441, 208, 504, 216 Annotation: Subtype: Link Rect: 369, 151, 436, 159 Annotation: Subtype: Link Rect: 498, 104, 549, 111 Annotation: Subtype: Link Rect: 316, 94, 351, 102 Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 261, 710, 289, 717 Annotation: Subtype: Link Rect: 55, 700, 120, 708 Annotation: Subtype: Link Rect: 263, 672, 289, 679 Annotation: Subtype: Link Rect: 55, 662, 85, 670 Annotation: Subtype: Link Rect: 105, 624, 205, 632 Annotation: Subtype: Link Rect: 192, 586, 289, 594 Annotation: Subtype: Link Rect: 55, 577, 74, 584 Annotation: Subtype: Link Rect: 263, 548, 289, 556 Annotation: Subtype: Link Rect: 55, 539, 107, 546 Annotation: Subtype: Link Rect: 68, 501, 124, 508 Annotation: Subtype: Link Rect: 342, 681, 397, 689 Annotation: Subtype: Link Rect: 492, 549, 549, 556 Annotation: Subtype: Link Rect: 306, 539, 387, 547 Annotation: Subtype: Link Rect: 45, 29, 123, 36 Annotation: Subtype: Link Rect: 131, 29, 189, 36 Annotation: Subtype: Link Rect: 436, 29, 549, 36 Checksum: ded8441b Type: CRC32 Checksum: 398a35e2a0ff725176a273dbc7869aed Type: MD5 Checksum: dba1698dc5a8d56f66ba9f50ab01b9dfa6d44798 Type: SHA-1