6a8b0cd33d0167987bea6120e757d3a1 284429.pdf 3f56f4c2c3db8d4d9ff79a7de243b00d56b70a85 284429.pdf 86542061bf5aa4a2ac0aa3a2f07b57cf61b1b2dd6396673f0e71cea1b1bf060c 284429.pdf Title: IgG Anti-High Density Lipoprotein Antibodies Are Elevated in Abdominal Aortic Aneurysm and Associated with Lipid Profile and Clinical Features Subject: High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA. Keywords: abdominal aortic aneurysm; autoantibodies; autoimmunity; HDLc Author: Javier Rodríguez-Carrio, Jes S. Lindholt, Marina Canyelles, Diego Martínez-López, Mireia Tondo, Luis M. Blanco-Colio, Jean-Baptiste Michel, Joan Carles Escolà-Gil, Ana Suárez and José Luis Martín-Ventura Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Dec 26 15:48:19 2019 CET ModDate: Thu Dec 26 15:48:19 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 518392 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LLNGWT+URWPalladioL-Ital Type 1 Custom yes yes no 83 0 RFSUTE+URWPalladioL-Bold Type 1 Custom yes yes no 84 0 JUXSQN+VnURWPalladioL-Bold Type 1 Custom yes yes no 85 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 86 0 XJTTIM+URWPalladioL-Roma Type 1 Custom yes yes no 87 0 EUNBMT+VnURWPalladioL Type 1 Custom yes yes no 88 0 NXPYWR+Pxsy Type 1 Builtin yes yes no 89 0 SYXPPI+Rpxr Type 1 Builtin yes yes no 90 0 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false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がちぢはひちぴはひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰えいがぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がちぢはひちぴはひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰えいがぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: がちぢはひちぴはひべぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰えいがぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰えいがぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰えいがぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐぬちびねちぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴど〭えいがぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ぁひづぜ〴ぜ〰ぉのっひづちびづつぜ〴ぜ〰どのぜ〴ぜ〰ぁぁぁぜ〴ぜ〰ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぉでぇぜ〴ぜ〰ぁのぴど〭えいがぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ぃちのぜ〴ぜ〰あづぜ〴ぜ〰いづぴづっぴづつぜ〴ぜ〰どのぜ〴ぜ〰ぁぁぁぜ〴ぜ〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぐぬちびねちぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰ぉでぇぜ〴ぜ〰ぁのぴど〭えいがぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ぁひづぜ〴ぜ〰ぉのっひづちびづつぜ〴ぜ〰どのぜ〴ぜ〰ぁぁぁぜ〴ぜ〰ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぉでぇぜ〴ぜ〰ぁのぴど〭えいがぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ぃちのぜ〴ぜ〰あづぜ〴ぜ〰いづぴづっぴづつぜ〴ぜ〰どのぜ〴ぜ〰ぁぁぁぜ〴ぜ〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉでぇぜ〴ぜ〰ぁのぴど〭えいがぜ〴ぜ〰ぁのぴどぢはつどづびぜ〴ぜ〰ぃちのぜ〴ぜ〰あづぜ〴ぜ〰いづぴづっぴづつぜ〴ぜ〰どのぜ〴ぜ〰ぁぁぁぜ〴ぜ〰ごどびびふづ〭ぃはのつどぴどはのづつぜ〴ぜ〰きづつどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: LLNGWT+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: LLNGWT+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RFSUTE+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: RFSUTE+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: 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