ad578d564d6c95dd9b44a6182115e143 284609.pdf 7d9a0fffe627cc46755f316d6e1e35f229b99f34 284609.pdf f646d39e0c0e8e13fa708ea78f6a1c45266076cbd413f0c007f265be7c42e78e 284609.pdf Title: Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register Subject: Arthritis Research & Therapy, 2020, doi:10.1186/s13075-020-02231-x Keywords: Rheumatoid arthritis,Ankylosing spondylitis,Psoriatic arthritis,Biologics,Elderly-onset rheumatoid arthritis Author: Paloma Vela Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jun 12 07:26:17 2020 CEST ModDate: Mon Jun 15 14:50:11 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 710621 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 17 0 GCKLLG+NldjlnAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 15 0 GCKPIA+JdlxptAdvTTe45e47d2 Type 1C WinAnsi yes yes no 16 0 GCKPIB+JtxthfAdvTTb5929f4c Type 1C WinAnsi yes yes no 144 0 GCKPOA+TqbxjlAdvTT99c4c969 Type 1C WinAnsi yes yes no 18 0 GCKPPB+HtwflqAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 174 0 GCLAPL+BknknhAdvTT7329fd89.I Type 1C WinAnsi yes yes no 19 0 GCLBDM+JxbltgAdvTT86d47313 Type 1C WinAnsi yes yes no 13 0 GCLBEM+QlltfpAdvTT86d47313+20 Type 1C WinAnsi yes yes no 14 0 GCLBIM+VxnscjAdvTT8861b38f.I Type 1C WinAnsi yes yes no 103 0 GCLBKM+LnwhbpAdvTT83913201.I Type 1C WinAnsi yes yes no 51 0 GCLBLN+PcrvbcAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 63 0 GCLEGO+PrqvyqAdvTTb5929f4c+03 Type 1C Custom yes yes yes 160 0 GCLECP+WmjkqcAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 162 0 GCLEKO+SwwwvgAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 166 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-15 02:41:20 CET RepresentationInformation: 284609.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-14 14:03:12 CET Size: 710621 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab1' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab2' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab3' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab4' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 559867 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 559867 MIMEtype: application/pdf PDFMetadata: Objects: 343 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Objectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Outcome variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: Factors related to the incidence of the first AE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Risk factors at the start of biological treatment on the time to a first AE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Info: Title: Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register Author: Paloma Vela Subject: Arthritis Research & Therapy, 2020, doi:10.1186/s13075-020-02231-x Keywords: Rheumatoid arthritis,Ankylosing spondylitis,Psoriatic arthritis,Biologics,Elderly-onset rheumatoid arthritis Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jun 12 07:26:17 CEST 2020 ModDate: Mon Jun 15 14:50:11 CEST 2020 ID: 0x7349e3299eda65b1afb91d6a58f8d342, 0x7314b1955ce858fc7d342001f81f2bd0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1182 ImageHeight: 859 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: GCLEGO+PrqvyqAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: GCLEGO+PrqvyqAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GCLECP+WmjkqcAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: GCLECP+WmjkqcAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLEKO+SwwwvgAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: GCLEKO+SwwwvgAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLBIM+VxnscjAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: GCLBIM+VxnscjAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLBDM+JxbltgAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: GCLBDM+JxbltgAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCKPPB+HtwflqAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GCKPPB+HtwflqAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLBEM+QlltfpAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: GCLBEM+QlltfpAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCKLLG+NldjlnAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: GCKLLG+NldjlnAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCKPIA+JdlxptAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: GCKPIA+JdlxptAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCKPIB+JtxthfAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: GCKPIB+JtxthfAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GCKPOA+TqbxjlAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: GCKPOA+TqbxjlAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLAPL+BknknhAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: GCLAPL+BknknhAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLBKM+LnwhbpAdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: GCLBKM+LnwhbpAdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GCLBLN+PcrvbcAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: GCLBLN+PcrvbcAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: Rheumatoid arthritis,Ankylosing spondylitis,Psoriatic arthritis,Biologics,Elderly-onset rheumatoid arthritis Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13075-020-02231-x Arthritis Research & Therapy Arthritis Research & Therapy, 2020, doi:10.1186/s13075-020-02231-x Rheumatoid arthritis Ankylosing spondylitis Psoriatic arthritis Biologics Elderly-onset rheumatoid arthritis Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register Paloma Vela Carlos Sanchez-Piedra Carolina Perez-Garcia María C. Castro-Villegas Mercedes Freire Lourdes Mateo Cesar Díaz-Torné Cristina Bohorquez Juan M. Blanco-Madrigal Inmaculada Ros-Vilamajo Silvia Gómez Rocio Caño Fernando Sánchez-Alonso Federico Díaz-González Juan J. Gómez-Reino 2020-06-15T14:50:11+02:00 2020-06-15T14:50:11+02:00 2020-06-12T13:26:17+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:847ab25c-6e76-43ad-8c8e-b32e616b6b5b uuid:d8616df6-9c64-49cc-9d0c-c44f76bb9ce8 default 1 converted uuid:847ab25c-6e76-43ad-8c8e-b32e616b6b5b converted to PDF/A-2b pdfToolbox 2020-06-12T15:56:36+08:00 2 B Federico Díaz-González http://orcid.org/0000-0002-4139-9295 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 519, 414, 528 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 183, 216, 190 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 91, 657, 96, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 133, 597, 138, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 597, 287, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 90, 501, 95, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 141, 477, 146, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 174, 417, 179, 426 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 100, 381, 105, 390 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 154, 321, 159, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 285, 147, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 152, 285, 162, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 91, 201, 100, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 102, 189, 112, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 141, 69, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 75, 141, 85, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 252, 117, 262, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 340, 459, 350, 468 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 423, 536, 432 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 273, 249, 278, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 378, 669, 383, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 501, 359, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 339, 453, 344, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 464, 178, 469, 187 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 481, 166, 486, 175 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 422, 225, 431, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 437, 225, 446, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 225, 461, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 225, 476, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 177, 451, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 403, 93, 413, 102 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 87, 333, 97, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 285, 179, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 245, 189, 255, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 262, 189, 271, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 278, 189, 288, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 177, 66, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 73, 177, 82, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 261, 165, 271, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 93, 117, 103, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 110, 117, 120, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 105, 269, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 105, 285, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 356, 321, 366, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 358, 261, 368, 270 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 435, 153, 445, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 153, 461, 162 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 59, 405, 69, 414 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 331, 393, 341, 402 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 194, 532, 202 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 185, 380, 193 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Thumb: true Checksum: c72148d5 Type: CRC32 Checksum: ad578d564d6c95dd9b44a6182115e143 Type: MD5 Checksum: 7d9a0fffe627cc46755f316d6e1e35f229b99f34 Type: SHA-1