4badbe0e3eed7a7c576ba7e132859632 284616.pdf de15551625ac33da6345db7fa4e9dd0d8de52538 284616.pdf 355465966998be053ad62d60e38c245051189063d74c54aae3cde0ed0de1da6d 284616.pdf Author: Medwave - Mednet Creator: Microsoft Word CreationDate: Mon Dec 7 22:11:15 2020 CET ModDate: Mon Dec 7 22:11:15 2020 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 700487 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BCDEEE+Garamond TrueType WinAnsi yes yes no 5 0 TimesNewRomanPSMT TrueType WinAnsi no no no 9 0 BCDFEE+Garamond-Bold TrueType WinAnsi yes yes no 12 0 TimesNewRomanPS-BoldMT TrueType WinAnsi no no no 14 0 BCDGEE+Garamond-Italic TrueType WinAnsi yes yes no 22 0 BCDHEE+CambriaMath CID TrueType Identity-H yes yes yes 26 0 BCDIEE+Garamond CID TrueType Identity-H yes yes yes 31 0 SymbolMT CID TrueType Identity-H yes no yes 36 0 ArialMT TrueType WinAnsi no no no 41 0 BCDJEE+Calibri TrueType WinAnsi yes yes no 69 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-16 02:39:11 CET RepresentationInformation: 284616.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-15 13:43:10 CET Size: 700487 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1347 FreeObjects: 1150 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Research Destination: 1 Children: Item: Title: Francisca Verdugo-Paivaa,b,*, , María Paz Acuñac,d, , Iván Soláe,f,g, , Gabriel Radaa,b,h, , COVID-19 L OVE Working Group Destination: 1 Children: Item: Title: a Epistemonikos Foundation, Santiago, Chile b UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile c Unidad de Infectología, Hospital Dr Sótero del Río, Santiago, Chile d Unidad de Infectologí... Destination: 1 Children: Item: Title: Abstract Destination: 1 Children: Item: Title: Objective Destination: 1 Item: Title: Provide a timely, rigorous and continuously updated summary of the evidence on the role of remdesivir in the treatment of patients with COVID-19. Destination: 1 Children: Item: Title: Methods Destination: 1 Item: Title: Eligible studies were randomized trials evaluating the effect of remdesivir versus placebo or no treatment. We conducted searches in the special L OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in data... Destination: 1 Children: Item: Title: Results Destination: 1 Item: Title: Our search strategy yielded 574 references. Finally, we included three randomized trials evaluating remdesivir in addition to standard care versus standard care alone. The evidence is very uncertain about the effect of remdesivir on mortality (RR 0.7,... Destination: 1 Children: Item: Title: Conclusions Destination: 1 Item: Title: The evidence is insufficient for the outcomes critical for making decisions on the role of remdesivir in the treatment of patients with COVID-19, so it is impossible to balance potential benefits, if there are any, with the adverse effects and costs. Destination: 1 Item: Title: PROSPERO Registration number: CRD42020183384. Destination: 1 Item: Title: Introduction Destination: 1 Children: Item: Title: Methods Destination: 1 Item: Title: Notes Destination: 1 Children: Item: Title: Authorship contributions Destination: 1 Item: Title: All the review authors drafted and revised the manuscript, conducted article screening and data collection, and drafted and revised the review. Destination: 1 Item: Title: The COVID-19 L OVE Working Group was created by Epistemonikos and a number of expert teams in order to provide decision-makers with the best evidence related to COVID-19. Up-to-date information about the group and its member organizations is available... Destination: 1 Item: Title: Acknowledgments Destination: 1 Item: Title: The members of the COVID-19 L OVE Working Group and Epistemonikos Foundation have made it possible to build the systems and compile the information needed by this project. Epistemonikos is a collaborative effort, based on the ongoing volunteer work of... Destination: 1 Item: Title: Competing interest Destination: 1 Item: Title: All authors declare no financial relationships with any organization that might have a real or perceived interest in this work. There are no other relationships or activities that might have influenced the submitted work. Destination: 1 Item: Title: Funding Destination: 1 Item: Title: This This project was not commissioned by any organization and did not receive external funding. Destination: 1 Item: Title: Epistemonikos Foundation is providing training, support and tools at no cost for all the members of the COVID-19 L OVE Working Group. Destination: 1 Children: Item: Title: Ethics Destination: 1 Item: Title: As researchers will not access information that could lead to the identification of an individual participant, obtaining ethical approval was waived. Destination: 1 Children: Item: Title: Data sharing Destination: 1 Item: Title: All data related to the project will be available. Epistemonikos Foundation will grant access to data. Destination: 1 Children: Item: Title: PROSPERO registration Destination: 1 Item: Title: CRD42020183384 Destination: 1 Children: Item: Title: Appendix Destination: 1 Item: Title: Appendix 1. Destination: 1 Item: Title: Appendix 2. Destination: 1 Item: Title: Appendix 3. 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