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Li Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Aug 21 15:46:33 2020 CEST ModDate: Thu Aug 27 07:59:08 2020 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 24 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2296581 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BOMLMG+AdvOTf23bb480+fb Type 1C Custom yes yes yes 360 0 BOMLMH+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 35 0 BOMLDD+AdvOTea1a7398 Type 1C WinAnsi yes yes no 37 0 BOMLJC+AdvTT2876772e+27 Type 1C Custom yes yes yes 593 0 BOMLJD+AdvOTea1a7398+fb Type 1C Custom yes yes yes 107 0 BOMLJE+AdvOTcb88df00 Type 1C WinAnsi yes yes no 42 0 Arial-BoldMT Type 1C WinAnsi yes no no 594 0 BOMLLF+AdvOTf23bb480 Type 1C WinAnsi yes yes no 364 0 BOMLOI+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 33 0 BOMLOJ+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 34 0 BOMLOH+AdvOT125c650c Type 1C WinAnsi yes yes no 36 0 BOMLPO+AdvTTab7e17fd+22 Type 1C Custom yes yes no 38 0 BOMLPP+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 39 0 BOMLPM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 40 0 BOMLPN+AdvTTab7e17fd Type 1C WinAnsi yes yes no 41 0 BOMLOK+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 43 0 BOMLOL+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 44 0 BOMNPH+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 103 0 Helvetica-Bold Type 1C WinAnsi yes no no 104 0 BOMNNF+Helvetica Type 1C WinAnsi yes yes no 105 0 BOMNOF+Helvetica-Oblique Type 1C WinAnsi yes yes no 106 0 BOMOBH+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 160 0 Symbol Type 1C Custom yes no yes 161 0 BONBOC+AdvOTcb88df00+fb Type 1C Custom yes yes yes 162 0 Helvetica-Oblique2 Type 1C WinAnsi yes no no 190 0 Helvetica-Bold2 Type 1C WinAnsi yes no no 191 0 Helvetica2 Type 1C WinAnsi yes no no 192 0 BONEEH+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 218 0 BONGLK+AdvP4C4E51 Type 1C WinAnsi yes yes no 267 0 BONGLL+AdvP4C4E46 Type 1C WinAnsi yes yes no 268 0 BONGKK+AdvP4C4E74 Type 1C Custom yes yes yes 269 0 BONGOL+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 324 0 BONHBL+AdvOTea1a7398+01 Type 1C Custom yes yes yes 361 0 BONHBM+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 362 0 BONHBN+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 363 0 BONIGG+AdvOTf23bb480+01 Type 1C Custom yes yes yes 459 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-17 17:12:07 CET RepresentationInformation: ICP02054.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-13 11:44:43 CET Size: 2296581 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 680 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Sex differences in oncogenic mutational processes Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Sex-biases in driver genes, mutation load and tumour evolution Destination: B1 Item: Title: Sex-biases in genome instability and CNAs Destination: B2 Item: Title: Sex-biases in mutational signatures Destination: B3 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: General statistical framework Destination: B4 Item: Title: Driver event analysis Destination: B5 Item: Title: Clonal structure and mutation timing analysis Destination: B6 Item: Title: SNV density analysis Destination: B7 Item: Title: Chromosome and genome instability analysis Destination: B8 Item: Title: Genome-spanning CNA analysis Destination: B9 Item: Title: Mutational signatures analysis Destination: B10 Item: Title: Reporting summary Destination: A4 Item: Title: Data availability Destination: M1 Item: Title: Code availability Destination: M2 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: Additional information Destination: M3 Info: Title: Sex differences in oncogenic mutational processes Author: Constance H. 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M. van Deurzen Marc J. van de Vijver L. van’t Veer Christian von Mering Springer US Nature Communications, doi:10.1038/s41467-020-17359-2 10.1038/s41467-020-17359-2 http://dx.doi.org/10.1038/s41467-020-17359-2 journal Nature Communications © 2020, The Author(s) 2041-1723 10.1038/s41467-020-17359-2 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-020-17359-2 springer.com springerlink.com Springer 2020-08-27T07:59:08+02:00 2020-08-21T19:16:33+05:30 2020-08-27T07:59:08+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:39f22a38-0b78-4b9d-9bac-fc583f071050 uuid:ccf6dec8-b7b6-4700-82a4-96094a05f787 default 1 converted uuid:b8b9390f-5eb4-4b80-ab73-e6816b2335af converted to PDF/A-2b pdfToolbox 2020-08-21T19:17:16+05:30 2 B Constance H. Li http://orcid.org/0000-0002-5487-7225 Stephenie D. Prokopec http://orcid.org/0000-0001-7936-8577 Paul C. 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