01e2dbee77deb3bc56994829469083d1  J_Assisted_Reproduction_and_Genetics_2020.pdf
7ed0fd3a60d64ca8d81344e1e612eca504642cd4  J_Assisted_Reproduction_and_Genetics_2020.pdf
a27b58b47c6d7a28b59e90c7dfc6101cfb53a2b6b01d888b29d1cecdc141bbd9  J_Assisted_Reproduction_and_Genetics_2020.pdf

Title:           ALWAYS ICSI? A SWOT analysis
Subject:         J Assist Reprod Genet, doi:10.1007/s10815-020-01836-0
Keywords:        Intracytoplasmic sperm injection (ICSI),In vitro fertilization (IVF),Severe non-male factor,Pregnancy,Assisted reproduction,Infertility
Author:          E. Bosch
Creator:         Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:        Acrobat Distiller 10.0.0 (Windows)
CreationDate:    Tue Jun 23 20:16:49 2020 CEST
ModDate:         Tue Jun 23 20:30:57 2020 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       441564 bytes
Optimized:       yes
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
DDDGGA+GhkgmsAdvTT99c4c969           Type 1C           WinAnsi          yes yes no     515  0
DDDHAN+CfxsbmAdvTT577c760c           Type 1C           WinAnsi          yes yes no     521  0
DDDHAO+NfdhjgAdvP0005                Type 1C           WinAnsi          yes yes no     522  0
DDDHAP+BbswfcAdvTTc488b0e6           Type 1C           WinAnsi          yes yes no     523  0
DDDHBA+YhlwbbAdvPi3                  Type 1C           WinAnsi          yes yes no     524  0
DDDHCB+LnksxlAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no     528  0
DDDHCC+TcxyrcAdvTT3713a231           Type 1C           WinAnsi          yes yes no     529  0
DDDHDC+GxvnfpAdvTT4ff65459           Type 1C           WinAnsi          yes yes no     534  0
DDDHGD+NmtlrnAdvTT50a2f13e.I         Type 1C           WinAnsi          yes yes no     168  0
DDDHGE+HxlvfrAdvTTa351d857.B         Type 1C           WinAnsi          yes yes no     171  0
DDDHFD+RkmmmhAdvTT3713a231+20        Type 1C           WinAnsi          yes yes no     174  0
DDDHKF+JxkpttAdvTT3713a231+22        Type 1C           Custom           yes yes yes    182  0
DDDHNF+KlsnrcAdvTT577c760c+20        Type 1C           WinAnsi          yes yes no     190  0
DDDIAE+MgghhwAdvTTb8864ccf.B         Type 1C           WinAnsi          yes yes no     220  0
DDDIEE+MqmphtAdvTTb8864ccf.B+20      Type 1C           WinAnsi          yes yes no     242  0
DDDIGE+LfbmfxAdvTT3713a231+03        Type 1C           Custom           yes yes yes    263  0
XbxwpfTimesNewRomanPS-BoldMT         Type 1C           WinAnsi          yes no  no     280  0
PQVCXU+PqvdxbArial                   Type 1C           WinAnsi          yes yes no     278  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-07-30 02:09:49 CEST
 RepresentationInformation: J_Assisted_Reproduction_and_Genetics_2020.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-07-29 12:10:50 CEST
  Size: 441564
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 602
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: ALWAYS ICSI? A SWOT analysis
      Destination: maintitle
      Children: 
       Item: 
        Title: Abstract
        Destination: Section11
       Item: 
        Title: Abstract
        Destination: Section12
       Item: 
        Title: Abstract
        Destination: Section13
       Item: 
        Title: Abstract
        Destination: Section14
       Item: 
        Title: Abstract
        Destination: Section15
       Item: 
        Title: Introduction
        Destination: Section16
       Item: 
        Title: Methods
        Destination: Section17
       Item: 
        Title: Results
        Destination: Section18
        Children: 
         Item: 
          Title: Strengths
          Destination: Section29
          Children: 
           Item: 
            Title: ICSI could increase fertilization rate and decrease fertilization failure in patients with unexplained infertility
            Destination: Section310
           Item: 
            Title: ICSI decreases fertilization failure in patients with mild male factor infertility or borderline semen
            Destination: Section311
           Item: 
            Title: Risk minimization for cycle cancelation due to total fertilization failure in couples with a prior failed fertilization using conventional insemination
            Destination: Section312
           Item: 
            Title: ICSI could improve embryo quality
            Destination: Section313
           Item: 
            Title: ICSI could increase pregnancy rates in patients with disordered zona pellucida–induced acrosome reaction
            Destination: Section314
           Item: 
            Title: Avoid possible contamination with DNA from spermatozoa in cases where PGT is performed for monogenic conditions
            Destination: Section315
         Item: 
          Title: Weakness
          Destination: Section216
          Children: 
           Item: 
            Title: No standardized guidelines to define “severe male factor” infertility
            Destination: Section317
           Item: 
            Title: Invasiveness of the technique
            Destination: Section318
           Item: 
            Title: Operator experience and technical factors are critical
            Destination: Section319
           Item: 
            Title: ICSI complications: imprinting defects and DNA methylation, possible sex ratio modification
            Destination: Section320
           Item: 
            Title: No benefit of ICSI on women-related factors of poor-prognosis
            Destination: Section321
           Item: 
            Title: No effect on reproductive outcomes
            Destination: Section322
           Item: 
            Title: No evidence of cost-benefit
            Destination: Section323
           Item: 
            Title: Lack of well-designed randomized controlled trials and inconsistencies in the results
            Destination: Section324
         Item: 
          Title: Opportunities
          Destination: Section225
          Children: 
           Item: 
            Title: Selection of the oocytes
            Destination: Section326
           Item: 
            Title: Sperm DNA fragmentation
            Destination: Section327
           Item: 
            Title: Technical improvements: selection of a good-quality semen with intact sperm genome (IMSI, PICSI, flow cytometry, reotaxis, swi洀ⴀ甀瀀㸾൥湤潢樍㔹㈠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀匀攀挀琀椀漀渀㌀㈀㜩⽆‰⽎數琠㔹ㄠ〠刯偡牥湴‵㜸‰⁒⽐牥瘠㔷㤠〠刯呩瑬攨Sperm DNA fragmentation
            Destination: Section328
           Item: 
            Title: Artificial oocyte activation
            Destination: Section329
           Item: 
            Title: Genome editing (CRISP/Cas9)
            Destination: Section330
         Item: 
          Title: Threats
          Destination: Section231
          Children: 
           Item: 
            Title: Predisposition to use ICSI (indiscriminate use/intolerance to fertilization failure)
            Destination: Section332
           Item: 
            Title: ICSI “overuse” during PGT
            Destination: Section333
           Item: 
            Title: Improvement of IVF
            Destination: Section334
           Item: 
            Title: Possible long-term effects of ICSI on children (infants, adults)
            Destination: Section335
       Item: 
        Title: Conclusion
        Destination: Section136
       Item: 
        Title: References
        Destination: Section137
   Info: 
    Title: ALWAYS ICSI? A SWOT analysis
    Author: E. Bosch
    Subject: J Assist Reprod Genet, doi:10.1007/s10815-020-01836-0
    Keywords: Intracytoplasmic sperm injection (ICSI),In vitro fertilization (IVF),Severe non-male factor,Pregnancy,Assisted reproduction,Infertility
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Tue Jun 23 20:16:49 CEST 2020
    ModDate: Tue Jun 23 20:30:57 CEST 2020
   ID: 0xb08e551c34fbe1307ea68bcdaae60d4e, 0x326f2f0dd49f754d86a15cd3c4d27f8a
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 1286
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: DDDGGA+GhkgmsAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 243
      FontDescriptor: 
       FontName: DDDGGA+GhkgmsAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDIGE+LfbmfxAdvTT3713a231+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: DDDIGE+LfbmfxAdvTT3713a231+03
       Flags: Symbolic
       FontBBox: -677, -229, 968, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DDDHGD+NmtlrnAdvTT50a2f13e.I
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: DDDHGD+NmtlrnAdvTT50a2f13e.I
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -208, 916, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHAN+CfxsbmAdvTT577c760c
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: DDDHAN+CfxsbmAdvTT577c760c
       Flags: Nonsymbolic
       FontBBox: -218, -250, 937, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHAO+NfdhjgAdvP0005
      FontSubset: true
      FirstChar: 32
      LastChar: 38
      FontDescriptor: 
       FontName: DDDHAO+NfdhjgAdvP0005
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1041, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHAP+BbswfcAdvTTc488b0e6
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: DDDHAP+BbswfcAdvTTc488b0e6
       Flags: Nonsymbolic
       FontBBox: -218, -250, 937, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHGE+HxlvfrAdvTTa351d857.B
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: DDDHGE+HxlvfrAdvTTa351d857.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 937, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHBA+YhlwbbAdvPi3
      FontSubset: true
      FirstChar: 32
      LastChar: 35
      FontDescriptor: 
       FontName: DDDHBA+YhlwbbAdvPi3
       Flags: Nonsymbolic
       FontBBox: -11, -345, 1373, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHFD+RkmmmhAdvTT3713a231+20
      FontSubset: true
      FirstChar: 32
      LastChar: 151
      FontDescriptor: 
       FontName: DDDHFD+RkmmmhAdvTT3713a231+20
       Flags: Nonsymbolic
       FontBBox: -468, -218, 1708, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHCB+LnksxlAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: DDDHCB+LnksxlAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHCC+TcxyrcAdvTT3713a231
      FontSubset: true
      FirstChar: 32
      LastChar: 246
      FontDescriptor: 
       FontName: DDDHCC+TcxyrcAdvTT3713a231
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -208, 927, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDIEE+MqmphtAdvTTb8864ccf.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: DDDIEE+MqmphtAdvTTb8864ccf.B+20
       Flags: Nonsymbolic
       FontBBox: -468, -208, 1666, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHDC+GxvnfpAdvTT4ff65459
      FontSubset: true
      FirstChar: 32
      LastChar: 42
      FontDescriptor: 
       FontName: DDDHDC+GxvnfpAdvTT4ff65459
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1354, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHKF+JxkpttAdvTT3713a231+22
      FontSubset: true
      FirstChar: 2
      LastChar: 22
      FontDescriptor: 
       FontName: DDDHKF+JxkpttAdvTT3713a231+22
       Flags: Symbolic
       FontBBox: 0, -270, 1052, 1020
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PQVCXU+PqvdxbArial
      FontSubset: true
      FirstChar: 0
      LastChar: 157
      FontDescriptor: 
       FontName: PQVCXU+PqvdxbArial
       Flags: Nonsymbolic
       FontBBox: -325, -159, 977, 491
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: XbxwpfTimesNewRomanPS-BoldMT
      FirstChar: 32
      LastChar: 148
      FontDescriptor: 
       FontName: XbxwpfTimesNewRomanPS-BoldMT
       Flags: Nonsymbolic
       FontBBox: -558, -328, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDIAE+MgghhwAdvTTb8864ccf.B
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: DDDIAE+MgghhwAdvTTb8864ccf.B
       Flags: Nonsymbolic
       FontBBox: -20, -208, 989, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DDDHNF+KlsnrcAdvTT577c760c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: DDDHNF+KlsnrcAdvTT577c760c+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1468, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>Intracytoplasmic sperm injection (ICSI),In vitro fertilization (IVF),Severe non-male factor,Pregnancy,Assisted reproduction,Infertility</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1007/s10815-020-01836-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Journal of Assisted Reproduction and Genetics</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">J Assist Reprod Genet, doi:10.1007/s10815-020-01836-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Intracytoplasmic sperm injection (ICSI)</rdf:li>
               <rdf:li>In vitro fertilization (IVF)</rdf:li>
               <rdf:li>Severe non-male factor</rdf:li>
               <rdf:li>Pregnancy</rdf:li>
               <rdf:li>Assisted reproduction</rdf:li>
               <rdf:li>Infertility</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">ALWAYS ICSI? A SWOT analysis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>E. Bosch</rdf:li>
               <rdf:li>J. J. Espinós</rdf:li>
               <rdf:li>F. Fabregues</rdf:li>
               <rdf:li>J. Fontes</rdf:li>
               <rdf:li>J. García-Velasco</rdf:li>
               <rdf:li>J. Llácer</rdf:li>
               <rdf:li>A. Requena</rdf:li>
               <rdf:li>M. A. Checa</rdf:li>
               <rdf:li>J. Bellver</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2020-06-24T02:16:49+08:00</xmp:CreateDate>
         <xmp:MetadataDate>2020-06-24T02:30:57+08:00</xmp:MetadataDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
         <xmp:ModifyDate>2020-06-24T02:30:57+08:00</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:DocumentID>uuid:ec94519a-69b6-4ee0-9e3e-8a9bd65ddf90</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:35075f8d-abbe-4c14-8a8a-634e64bf9a45</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:8e2134c2-d933-44a6-a3da-f66fed291f4e</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-06-24T02:30:57+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 489, 669, 544, 724
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 445, 261, 450, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 520, 224, 525, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 340, 174, 345, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 500, 124, 505, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 66, 293, 159, 301
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 522, 59, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 63, 522, 68, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 134, 360, 186, 370
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 244, 248, 249, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 118, 99, 122, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 478, 722, 488, 732
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 402, 709, 412, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 458, 684, 463, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 419, 572, 429, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 437, 472, 447, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 309, 348, 319, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 438, 311, 448, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 453, 311, 463, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 457, 248, 467, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 385, 186, 395, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 434, 243, 444
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 407, 471, 417, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 453, 409, 463, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 51, 685, 146, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 675, 159, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 665, 146, 673
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 585, 191, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 250, 535, 259, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 54, 472, 64, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 217, 472, 227, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 215, 385, 225, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 273, 298, 283, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 72, 99, 82, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 410, 709, 420, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 425, 709, 434, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 518, 535, 528, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 528, 385, 538, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 309, 273, 319, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 323, 273, 333, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 360, 174, 370, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 442, 99, 452, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 457, 99, 466, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 494, 74, 504, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 75, 634, 85, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 273, 585, 283, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 211, 435, 221, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 165, 410, 175, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 172, 385, 182, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 145, 298, 155, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 125, 174, 135, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 309, 684, 319, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 324, 684, 333, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 309, 672, 319, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 467, 672, 477, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 398, 547, 403, 557
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 446, 497, 456, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 351, 472, 361, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 493, 323, 503, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 309, 298, 319, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 324, 298, 333, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 368, 248, 378, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 506, 211, 516, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 379, 74, 389, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 195, 198, 205, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 273, 86, 283, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 467, 509, 476, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 387, 459, 397, 469
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 364, 410, 374, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 528, 336, 538, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 469, 286, 479, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 485, 286, 495, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 424, 261, 433, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 327, 223, 336, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 424, 161, 433, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 647, 248, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 95, 535, 105, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 253, 497, 262, 507
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 99, 460, 108, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 113, 460, 123, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 175, 336, 185, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 169, 211, 179, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 73, 149, 83, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 211, 149, 221, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 414, 722, 424, 732
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 429, 722, 439, 732
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 477, 709, 488, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 494, 709, 504, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 511, 709, 521, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 528, 709, 538, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 420, 634, 430, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 436, 634, 446, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 451, 634, 461, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 467, 634, 477, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 419, 560, 429, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 411, 136, 420, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 227, 659, 237, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 229, 522, 234, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 118, 410, 129, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 459, 659, 469, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 474, 659, 484, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 483, 634, 493, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 498, 634, 508, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 398, 597, 408, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 309, 535, 319, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 323, 535, 333, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 349, 510, 359, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 364, 510, 378, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 309, 435, 319, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 399, 410, 409, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 709, 69, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 74, 709, 90, 719
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 97, 572, 112, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 186, 547, 200, 557
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 69, 398, 84, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 461, 697, 466, 707
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 329, 125, 456, 134
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
  Checksum: 028feeeb
   Type: CRC32
  Checksum: 01e2dbee77deb3bc56994829469083d1
   Type: MD5
  Checksum: 7ed0fd3a60d64ca8d81344e1e612eca504642cd4
   Type: SHA-1
  Checksum: a27b58b47c6d7a28b59e90c7dfc6101cfb53a2b6b01d888b29d1cecdc141bbd9
   Type: SHA-256