4e3ddb1bcdac4b1e51abef29138901ba pmc_32650491.pdf a95a062c97bc4362dd38919fe08270805bcbb575 pmc_32650491.pdf 56bcb3f80efdf9b38b5e4be70ae90f31e8d1e3bf0998ef3e7d23084b7b08be36 pmc_32650491.pdf Title: Patterns of Antibiotic Prescription in Colombia: Are There Differences between Capital Cities and Municipalities? Subject: The use of antibiotics is the most important modifiable risk factor for the development of microorganism resistance. A cross-sectional study of outpatients receiving antibiotic prescriptions registered in a population database in Colombia was conducted. The characteristics of the consumption in capital cities and small municipalities was studied and the AWaRe classification was used. AWaRe classifies antibiotics into three stewardship groups: Access, Watch and Reserve, to emphasize the importance of their optimal use and potential harms of antimicrobial resistance. A total of 182,397 patients were prescribed an antibiotic; the most common were penicillins (38.6%), cephalosporins (30.2%) and fluoroquinolones (10.9%). ‘Access’ antibiotics (86.4%) were the most frequently prescribed, followed by ‘Watch’ antibiotics (17.0%). Being 18 or older, being male, living in a municipality, having one or more comorbidities and urinary, respiratory or gastrointestinal disorders increased the probability of receiving ‘Watch’ or ‘Reserve’ antibiotics. Penicillin and urinary antiseptic prescriptions predominated in cities, while cephalosporin and fluoroquinolone prescriptions predominated in municipalities. This analysis showed that the goal set by the WHO Access of mainly using Access antibiotics is being met, although the high use of Watch antibiotics in municipalities should be carefully studied to determine if it is necessary to design specific campaigns to improve antibiotics use. Keywords: antibiotic prescription; AWaRe classification; Colombia; rural/urban consumption; fluoroquinolones; cephalosporins; drug utilization study Author: Jorge Enrique Machado-Alba, Luis Fernando Valladales-Restrepo, Andrés Gaviria-Mendoza, Manuel Enrique Machado-Duque and Albert Figueras Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Jul 8 13:05:14 2020 CEST ModDate: Wed Jul 8 13:05:14 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 269358 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NMDEKH+URWPalladioL-Ital Type 1 Custom yes yes no 70 0 RFAHNX+URWPalladioL-Bold Type 1 Custom yes yes no 71 0 PQOKRE+Rpxb Type 1 Builtin yes yes no 72 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 73 0 SDLCNI+URWPalladioL-Roma 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