e44f501daadc87fae4c322fce5a614eb pmc_32731455.pdf 1e2bb8544112e4858724dd253ada118a8f453010 pmc_32731455.pdf edfb9cdf669b0fea509fe22be5e913dd09c24c37850dac192c72e6502f77c67b pmc_32731455.pdf Title: High Effectiveness of a 14-Day Concomitant Therapy for Helicobacter pylori Treatment in Primary Care. An Observational Multicenter Study Subject: Background: The current cure rates with triple therapy combining a proton-pump inhibitor, amoxicillin and clarithromycin are unacceptably low. Aims: To evaluate the efficacy of a 14-day concomitant therapy as an empirical first-line treatment for curing Helicobacter pylori (Hp) infection in primary care. Methods: Patients from six primary care centers in Catalonia -Spain- were included consecutively. Hp status pre and post treatment was assessed according to local clinical practice protocol. A 14-day concomitant therapy (amoxicillin 1 g, clarithromycin 500 mg and metronidazole 500 mg plus omeprazole 20 mg, all drugs administered twice daily) was prescribed. Adherence to therapy and adverse events were assessed by personal interview. Results: 112 patients were enrolled. Mean age was 46.7 16.1 years. Main indication for treatment was non-investigated dyspepsia (83%). Hp eradication was achieved in 100 of the 112 patients. Eradication rates were 89.3% (95% CI: 81.7–94.1) by intention-to-treat (ITT) analysis and 91.7% (95% CI; 84.6–95.9) per protocol (PP). No major side effects were reported; 104 (92.8%) patients complete the treatment. Forty-seven patients (42%) complained of mild side effects (metallic taste, nausea). Low adherence to treatment (p = 0.004) and significant adverse events (p = 0.004) were the variables associated with treatment failure. Conclusions: In primary care, a 14-day concomitant therapy is highly effective and well tolerated. Keywords: Helicobacter; eradication; treatment; concomitant; primary care; multicenter Author: Llum Olmedo, Rafael Azagra, Amada Aguyé, Marta Pascual, Xavier Calvet and Emili Gené Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Jul 28 12:24:57 2020 CEST ModDate: Tue Jul 28 12:24:57 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 575958 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QGIXEP+URWPalladioL-Ital Type 1 Custom yes yes no 49 0 ZCFCCJ+URWPalladioL-Bold Type 1 Custom yes yes no 50 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 51 0 UJLZEY+URWPalladioL-BoldItal Type 1 Custom yes yes no 52 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 53 0 RGZQRI+URWPalladioL-Roma Type 1 Custom yes yes no 54 0 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