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CID TrueType Identity-H yes yes yes 343 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:18:37 CEST RepresentationInformation: pmc_32784955.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:43:24 CEST Size: 4843046 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 555 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Experimental Section Destination: section.2 Children: Item: Title: Animal Studies Destination: subsection.2.1 Children: Item: Title: Topical ocular Treatment Destination: subsubsection.2.1.1 Item: Title: Electroretinogram Destination: subsubsection.2.1.2 Item: Title: Immunohistochemical Analysis for Glial Activation Assessment Destination: subsubsection.2.1.3 Item: Title: Immunohistochemical Analysis for Apoptosis Assessment Destination: subsubsection.2.1.4 Item: Title: Glutamate Quantification Destination: subsubsection.2.1.5 Item: Title: Immunohistochemistry for GLAST Destination: subsubsection.2.1.6 Item: Title: In Vitro and Ex Vivo Studies Destination: subsection.2.2 Children: Item: Title: Reagents and Antibodies Destination: subsubsection.2.2.1 Item: Title: Cell Culture Destination: subsubsection.2.2.2 Item: Title: Analysis of the Cellular Viability by Crystal Violet Staining Destination: subsubsection.2.2.3 Item: Title: Analysis of Nitrites (NO2-) Destination: subsubsection.2.2.4 Item: Title: Retinal Explants Destination: subsubsection.2.2.5 Item: Title: Analysis of Reactive Gliosis Immunofluorescence in Retinal Explants Destination: subsubsection.2.2.6 Item: Title: Cytokine Detection Assay Destination: subsubsection.2.2.7 Item: Title: Quantitative Real-Time PCR (RT-qPCR) Destination: subsubsection.2.2.8 Item: Title: Western Blot Destination: subsubsection.2.2.9 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Neurodegeneration Was Prevented in Retinas from db/db Mice Treated with SST Topically Administered Destination: subsection.3.1 Children: Item: Title: Müller Glial Cells Activation Destination: subsubsection.3.1.1 Item: Title: Microglial Activation Destination: subsubsection.3.1.2 Item: Title: Apoptosis Destination: subsubsection.3.1.3 Item: Title: ERG Abnormalities Destination: subsubsection.3.1.4 Item: Title: SST Prevents the Increase of Glutamate Induced by Diabetes by Inhibiting GLAST Downregulation Destination: subsection.3.2 Item: Title: SST Prevented the Pro-Inflammatory Response in Bv.2 Cells Stimulated with LPS Destination: subsection.3.3 Item: Title: Decreased iNOS Expression in Retinal Explants Exposed to Conditioned Medium (CM) from LPS-Stimulated Bv.2 Microglial Cells Pre-Treated with SST Destination: subsection.3.4 Item: Title: SST Decreases Reactive Gliosis in Retinal Explants from db/db Mice Destination: subsection.3.5 Item: Title: SST Decreased Inflammatory Markers Induced by Hypoxia and a Defined Diabetic Milieu in Bv.2 Microglia Cells Destination: subsection.3.6 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.4 Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Fri Aug 14 09:46:41 CEST 2020 ModDate: Fri Aug 14 09:46:41 CEST 2020 ID: 0x16978a396ab5fd0341f9f5600e36dadc, 0x16978a396ab5fd0341f9f5600e36dadc Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FATHTC+Rpxr FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: FATHTC+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: HIKPNZ+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 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