75b9bb9e4446895111dab166ae1a2f84 pmc_32824737.pdf 792dca4953dedaaba4d4181c70b04cd4f65e5df7 pmc_32824737.pdf 70fb89fa787a1a105c458e6165eec82393db1250e5a7f6bf7e771d30151281c4 pmc_32824737.pdf Title: Alcohol Induced Depression: Clinical, Biological and Genetic Features Subject: Background: In clinical practice, there is the need to have clinical and biological markers to identify induced depression. The objective was to investigate clinical, biological and genetic differences between Primary Major Depression (Primary MD) and Alcohol Induced MD (AI-MD). Methods: Patients, of both genders, were recruited from psychiatric hospitalisation units. The PRISM instrument was used to establish the diagnoses. Data on socio-demographic/family history, clinical scales for depression, anxiety, personality and stressful life events were recorded. A blood test was performed analysing biochemical parameters and a Genome Wide Association Study (GWAS) to identify genetic markers associated with AI-MD. Results: A total of 80 patients were included (47 Primary MD and 33 AI-MD). The AI-MD group presented more medical comorbidities and less family history of depression. There were differences in traumatic life events, with higher scores in the AI-MD (14.21 11.35 vs. 9.30 7.38; p = 0.021). DSM-5 criteria were different between groups with higher prevalence of weight changes and less anhedonia, difficulties in concentration and suicidal thoughts in the AI-MD. None of the genetic variants reached significance beyond multiple testing thresholds; however, some suggestive variants were observed. Conclusions: This study has found clinical and biological features that may help physicians to identify AI-MD and improve its therapeutic approach. Keywords: primary major depression; alcohol use disorder; alcohol induced major depression; biomarkers; comorbidity; clinical characteristics; GWAS Author: Adriana Farré, Judit Tirado, Nino Spataro, María Alías-Ferri, Marta Torrens and Francina Fonseca Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Aug 18 12:04:06 2020 CEST ModDate: Tue Aug 18 12:04:06 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1029142 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PJNWTZ+URWPalladioL-Ital Type 1 Custom yes yes no 130 0 TMKREN+URWPalladioL-Bold Type 1 Custom yes yes no 131 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 132 0 TGBEVB+URWPalladioL-Roma Type 1 Custom yes yes no 133 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes 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Subtype: Link Rect: 143, 121, 179, 131 Annotation: Subtype: Link Rect: 418, 82, 455, 92 Annotation: Subtype: Link Rect: 461, 82, 497, 92 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 100, 715, 137, 725 Annotation: Subtype: Link Rect: 325, 675, 363, 686 Annotation: Subtype: Link Rect: 181, 625, 219, 635 Annotation: Subtype: Link Rect: 453, 598, 490, 609 Annotation: Subtype: Link Rect: 319, 559, 357, 570 Annotation: Subtype: Link Rect: 318, 521, 355, 531 Annotation: Subtype: Link Rect: 304, 482, 341, 493 Annotation: Subtype: Link Rect: 348, 482, 384, 493 Annotation: Subtype: Link Rect: 426, 443, 464, 454 Annotation: Subtype: Link Rect: 470, 443, 506, 454 Annotation: Subtype: Link Rect: 136, 405, 174, 415 Annotation: Subtype: Link Rect: 180, 405, 216, 415 Annotation: Subtype: Link Rect: 205, 379, 242, 389 Annotation: Subtype: Link Rect: 248, 379, 284, 389 Annotation: Subtype: Link Rect: 136, 328, 174, 338 Annotation: Subtype: Link Rect: 227, 289, 265, 299 Annotation: 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Subtype: Link Rect: 409, 624, 447, 635 Annotation: Subtype: Link Rect: 453, 624, 489, 635 Annotation: Subtype: Link Rect: 219, 560, 257, 570 Annotation: Subtype: Link Rect: 136, 508, 174, 519 Annotation: Subtype: Link Rect: 239, 470, 276, 480 Annotation: Subtype: Link Rect: 172, 444, 210, 454 Annotation: Subtype: Link Rect: 323, 417, 360, 428 Annotation: Subtype: Link Rect: 76, 375, 166, 406 Annotation: Subtype: Link Rect: 234, 369, 407, 380 Checksum: 8a91271d Type: CRC32 Checksum: 75b9bb9e4446895111dab166ae1a2f84 Type: MD5 Checksum: 792dca4953dedaaba4d4181c70b04cd4f65e5df7 Type: SHA-1