de568723d3d34ea564ada6194af9f8cb pmc_32899475.pdf b1c398846e7e29e565d592ed809eb593c4e38105 pmc_32899475.pdf 497c1c923e43d9b6c8f3eee3d29b032fc5e52e7e78d4a774419b3d824571e04a pmc_32899475.pdf Title: Maternal Transmission Ratio Distortion in Two Iberian Pig Varieties Subject: Transmission ratio distortion (TRD) is defined as the allele transmission deviation from the heterozygous parent to the offspring from the expected Mendelian genotypic frequencies. Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. Genotypes from a total of 247 families (dam and offspring) of Entrepelado (n = 129) and Retinto (n = 118) Iberian varieties were analyzed. The offspring were sired by both ungenotyped purebred Retinto and Entrepelado Iberian boars, regardless of the dam variety used. After quality control, 16,246 single-nucleotide polymorphisms (SNPs) in the Entrepelado variety and 9744 SNPs in the Retinto variety were analyzed. Maternal TRD was evaluated by a likelihood ratio test under SNP-by-SNP, adapting a previous model solved by Bayesian inference. Results provided 68 maternal TRD loci (TRDLs) in the Entrepelado variety and 24 in the Retinto variety (q < 0.05), with mostly negative TRD values, increasing the transmission of the minor allele. In addition, both varieties shared ten common TRDLs. No strong evidence of biological effects was found in genes with TRDLs. However, some biological processes could be affected by TRDLs, such as embryogenesis at different levels and lipid metabolism. These findings could provide useful insight into the genetic mechanisms to improve the swine industry, particularly in traditional breeds. Keywords: genome scan; maximum likelihood; segregation distortion; Sus scrofa; ungenotyped parents Author: Marta Vázquez-Gómez, Melani Martín de Hijas-Villalba, Luis Varona, Noelia Ibañez-Escriche, Juan Pablo Rosas, Sara Negro, José Luis Noguera and Joaquim Casellas Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Sep 5 09:11:40 2020 CEST ModDate: Sat Sep 5 09:11:40 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 736947 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNKYUY+URWPalladioL-Ital Type 1 Custom yes yes no 79 0 PFNHPI+URWPalladioL-Bold Type 1 Custom yes yes no 80 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 81 0 HCEXSC+URWPalladioL-Roma Type 1 Custom yes yes no 82 0 OPNYWB+VnURWPalladioL Type 1 Custom 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Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬび〬ぜ〴ぜ〰いちぴち〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅのひどっとねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁぶちどぬちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぁのどねちぬび〬ぜ〴ぜ〰いちぴち〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅのひどっとねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁぶちどぬちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅのひどっとねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁぶちどぬちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅのひどっとねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁぶちどぬちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いちぴちぜ〴ぜ〰ぁぶちどぬちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅびぴどねちぴづびぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰がはっどぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぐはびびどぢぬづぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰ぉねばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰がはっどぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぅびぴどねちぴづびぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰がはっどぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぐはびびどぢぬづぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰ぉねばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰がはっどぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぐはびびどぢぬづぜ〴ぜ〰あどはぬはでどっちぬぜ〴ぜ〰ぉねばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰げちぴどはぜ〴ぜ〰いどびぴはひぴどはのぜ〴ぜ〰がはっどぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PFNHPI+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 241 FontDescriptor: FontName: PFNHPI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GBLQZB+Rpxi 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