bd968e7de06f140051382286b6f8a805 pmc_32932852.pdf ac3e0d02f2e835d7270aac39a4dab8a8229dee75 pmc_32932852.pdf bd33ab6c2d74866f9d475fbfd9b8b885f16ebddb3b9bcd6357a87494d014a277 pmc_32932852.pdf Title: Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity Subject: Menopause strongly increases incidence and consequences of obesity and non-communicable diseases in women, with recent research suggesting a very early onset of changes in lipid accumulation, dyslipidemia, and insulin resistance. However, there is a lack of adequate preclinical models for its study. The present trial evaluated the usefulness of an alternative method to surgical ovariectomy, the administration of two doses of a GnRH analogue-protein conjugate (Vacsincel®), for inducing ovarian inactivity in sows used as preclinical models of obesity and menopause. All the sows treated with the compound developed ovarian stoppage after the second dose and, when exposed to obesogenic diets during the following three months, showed changes in the patterns of fat deposition, in the fatty acids profiles at the different tissues and in the plasma concentrations of fructosamine, urea, -hydroxibutirate, and haptoglobin when compared to obese fed with the same diet but maintaining ovarian activity. Altogether, these results indicate that menopause early augments the deleterious effects induced by overfeeding and obesity on metabolic traits, paving the way for future research on physiopathology of these conditions and possible therapeutic targets using the swine model. Keywords: models; fatty-acids; insulin-resistance; menopause; obesity; swine Author: Ana Heras-Molina, José Luis Pesantez-Pacheco, Marta Vazquez-Gomez, Consolacion Garcia-Contreras, Susana Astiz, Beatriz Isabel and Antonio Gonzalez-Bulnes Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Sep 11 11:01:44 2020 CEST ModDate: Fri Sep 11 11:01:44 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1684240 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CVDNRL+URWPalladioL-Ital Type 1 Custom yes yes no 102 0 UZRFNH+URWPalladioL-Bold Type 1 Custom yes yes no 103 0 WOZBHT+Rpxb Type 1 Builtin yes yes no 104 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 105 0 KGNTLU+URWPalladioL-Roma Type 1 Custom yes yes no 106 0 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IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰こづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰くぶちひどちのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぅぴとどっびぜ〴ぜ〰こぴちぴづねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰くぶちひどちのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁのどねちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰くぶちひどちのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁびびづびびねづのぴぜ〴ぜ〰はてぜ〴ぜ〰くぶちひどちのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつびぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰あはつべぜ〴ぜ〰きちびびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはびどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰こふぢっふぴちのづはふびぜ〴ぜ〰ちのつぜ〴ぜ〰ざどびっづひちぬぜ〴ぜ〰うちぴぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎはの〭ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰きふびっぬづぜ〴ぜ〰ちのつぜ〴ぜ〰がどぶづひぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰あはつべぜ〴ぜ〰きちびびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはびどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰こふぢっふぴちのづはふびぜ〴ぜ〰ちのつぜ〴ぜ〰ざどびっづひちぬぜ〴ぜ〰うちぴぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎはの〭ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰きふびっぬづぜ〴ぜ〰ちのつぜ〴ぜ〰がどぶづひぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴちぴふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰こふぢっふぴちのづはふびぜ〴ぜ〰ちのつぜ〴ぜ〰ざどびっづひちぬぜ〴ぜ〰うちぴぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎはの〭ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰きふびっぬづぜ〴ぜ〰ちのつぜ〴ぜ〰がどぶづひぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰こふぢっふぴちのづはふびぜ〴ぜ〰ちのつぜ〴ぜ〰ざどびっづひちぬぜ〴ぜ〰うちぴぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎはの〭ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰きふびっぬづぜ〴ぜ〰ちのつぜ〴ぜ〰がどぶづひぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃとちのでづびぜ〴ぜ〰どのぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎはの〭ぁつどばはびづぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ぜ〵ぜ〰きふびっぬづぜ〴ぜ〰ちのつぜ〴ぜ〰がどぶづひぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: CVDNRL+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: CVDNRL+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UZRFNH+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: UZRFNH+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 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