d3981c169061d395b435339a9861d288 pmc_32962285.pdf db0fd69d42908ac601a2f5c87fd699fb7862e1dc pmc_32962285.pdf f3cadc64cabd0da073fd01295316344b8b3e438fa4c2144aac1faf4475b8ac35 pmc_32962285.pdf Title: Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use Subject: Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in animal models and biopsies from patients with irritable bowel syndrome (IBS). Therefore, mast cells and mast cell mediators are regarded as key components in IBS pathophysiology. IBS is a common functional gastrointestinal disorder affecting the quality of life of up to 20% of the population worldwide. It is characterized by abdominal pain and altered bowel habits, with heterogeneous phenotypes ranging from constipation to diarrhea, with a mixed subtype and even an unclassified form. Nutrient intake is one of the triggering factors of IBS. In this respect, certain components of the daily food, such as fatty acids, amino acids or plant-derived substances like flavonoids, have been described to modulate mast cells’ activity. In this review, we will focus on the effect of these molecules, either stimulatory or inhibitory, on mast cell degranulation, looking for a nutraceutical capable of decreasing IBS symptoms. Keywords: cannabidiol; fatty acids; heparin; histamine; irritable bowel syndrome; mast cells; nerve growth factor; nutraceuticals; polyphenols; visceral pain Author: José Antonio Uranga, Vicente Martínez and Raquel Abalo Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Sep 20 12:24:29 2020 CEST ModDate: Sun Sep 20 12:24:29 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 30 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 765325 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FITCUW+URWPalladioL-Ital Type 1 Custom yes yes no 103 0 QKQNTI+URWPalladioL-Bold Type 1 Custom yes yes no 104 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 105 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 106 0 FPRRUE+URWPalladioL-Roma Type 1 Custom yes yes no 107 0 TYUELJ+VnURWPalladioL Type 1 Custom yes 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ぃちののちぢどのはどつび〬ぜ〴ぜ〰ぃちののちぢどのはどつ〭げづぬちぴづつぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰ちのつぜ〴ぜ〰くぴとづひぜ〴ぜ〰がどばどつどっぜ〴ぜ〰きはぬづっふぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸱⸳ Item: Title: うちぴ〭こはぬふぢぬづぜ〴ぜ〰ざどぴちねどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぁねどのはぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぃちひはぴづのはどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぬべばとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸴⸱ Item: Title: ぁねどのはぜ〴ぜ〰ぁっどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぃちひはぴづのはどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぬべばとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸴⸱ Item: Title: ぃちひはぴづのはどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぬべばとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸴⸱ Item: Title: ぐはぬべばとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸴⸱ Children: Item: Title: うぬちぶはのはどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸴⸲ Item: Title: くぴとづひぜ〴ぜ〰ぐはぬべばとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰こばどっづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸵⸱ Item: Title: こばどっづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸵⸱ Children: Item: Title: ぃふひっふねどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸵⸲ Item: Title: ぃどののちねはのぜ〴ぜ〰ぅへぴひちっぴぜ〲㑜〰ぃどののちねちぬつづとべつづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡦楧畲攮捡灴楯渮㄰ Item: Title: げづてづひづのっづび Filters: 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