64f1ae50134ee8eb1a006c2a864dfb25 pmc_33019725.pdf 5c8ec9bd03a8eb7dc2dcb2ebdef1cca8a7d3b509 pmc_33019725.pdf 7707c398be1f6f2e183b03479647b63c32516e4dfc4162128dfa40b72d585629 pmc_33019725.pdf Title: Additional Metabolic Effects of Bariatric Surgery in Patients with a Poor Mid-Term Weight Loss Response: A 5-Year Follow-Up Study Subject: To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20.3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45.8% vs. poor WL, p = 0.005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained. Keywords: bariatric surgery; obesity; severe obesity; weight loss; weight regain; sleeve gastrectomy; gastric bypass Author: David Benaiges, Maria Bisbe, Juan Pedro-Botet, Aleix de Vargas-Machuca, Jose M. Ramon, Manuel Pera, Montserrat Villatoro, Laia Fontané, Helena Julià, Elisenda Climent, Olga Castañer, Juana A. Flores-Le Roux and Alberto Goday Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Oct 17 14:20:23 2020 CEST ModDate: Tue Oct 20 03:48:47 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1834788 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MWJZGO+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 IEFSKB+VnURWPalladioL Type 1 Custom yes yes no 15 0 FGIIOZ+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 HQSYUF+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 RQODNN+Rpxb Type 1 Builtin yes yes no 28 0 DOTYPJ+URWPalladioL-Roma Type 1 Custom yes yes no 32 0 SYXPPI+Rpxr Type 1 Builtin yes yes no 36 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 47 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 LDXHGM+Pxsy Type 1 Builtin yes yes no 87 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 94 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 139 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 146 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-13 02:36:32 CET RepresentationInformation: pmc_33019725.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-11-02 03:37:40 CET Size: 1834788 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 274 FreeObjects: 7 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Experimental Section Destination: section.2 Children: Item: Title: Study Protocol Destination: subsection.2.1 Item: Title: Anthropometric and Biochemical Measurements Destination: subsection.2.2 Item: Title: Surgical Techniques Destination: subsection.2.3 Item: Title: Study Power Calculation Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Additional Metabolic Effects of Bariatric Surgery in Patients with a Poor Mid-Term Weight Loss Response: A 5-Year Follow-Up Study Author: David Benaiges, Maria Bisbe, Juan Pedro-Botet, Aleix de Vargas-Machuca, Jose M. Ramon, Manuel Pera, Montserrat Villatoro, Laia Fontané, Helena Julià, Elisenda Climent, Olga Castañer, Juana A. Flores-Le Roux and Alberto Goday Subject: To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20.3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45.8% vs. poor WL, p = 0.005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained. 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