cc65f37bab5b67b4f6578e83ed59a683 pmc_33053631.pdf d03db0c2a46754a86a249793424d78c77408ce4e pmc_33053631.pdf aa8fe16d5d90384899dd1ca6ec197bc4e40c206ed0a15b3faa9e052f4f90deef pmc_33053631.pdf Title: Microbiota, Fiber, and NAFLD: Is There Any Connection? Subject: Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including diet, showing the possibility to modify components of gastrointestinal dysbiota towards healthy and multivariate microbiota to restore physiologic status. One of the main focuses has been dietary fiber (DF), in which most of its variants are prebiotics. The highest effective treatment for NAFLD is, so far, weight loss achieved by caloric restriction. DF supplementation with oligofructose facilitates weight loss, enhances the production of beneficial metabolites, decreases some pathogenic bacteria population by increasing Bifidobacteria, and has effects on intestinal barrier permeability. DF use has been associated with improvement in diverse metabolic diseases, including NAFLD, by modifying gut microbiota. Additionally, it has been shown that a higher insoluble fiber consumption (7.5 g/day) revealed improvements in 3 different scores of liver fibrosis. Further research is needed, but given the evidence available, it is reasonable to prescribe its consumption in early stages of NAFLD in order to prevent disease progression. Keywords: NAFLD; NASH; microbiota; fiber; prebiotics; diet Author: Alejandra Pérez-Montes de Oca, María Teresa Julián, Analía Ramos, Manel Puig-Domingo and Nuria Alonso Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Oct 13 10:59:00 2020 CEST ModDate: Tue Oct 13 11:01:18 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 294302 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KBGDTY+VnURWPalladioL Type 1 Custom yes yes no 10 0 ETPDKS+Pxsy Type 1 Builtin yes yes no 15 0 HAWHPF+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 ZRFVQI+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 KQFPNF+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 HAKARX+Rpxr Type 1 Builtin yes yes no 32 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 36 0 CUAJJQ+Pxbsy Type 1 Builtin yes yes no 40 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 70 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 74 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 78 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 88 0 MFIGJL+Rpxb Type 1 Builtin yes yes no 95 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 114 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-01 02:30:14 CEST RepresentationInformation: pmc_33053631.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-02 03:37:10 CET Size: 294302 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 302 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Intestinal Microbiota Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Dietary Fiber and Prebiotics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Dietary Fiber and NAFLD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Info: Title: Microbiota, Fiber, and NAFLD: Is There Any Connection? Author: Alejandra Pérez-Montes de Oca, María Teresa Julián, Analía Ramos, Manel Puig-Domingo and Nuria Alonso Subject: Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including diet, showing the possibility to modify components of gastrointestinal dysbiota towards healthy and multivariate microbiota to restore physiologic status. One of the main focuses has been dietary fiber (DF), in which most of its variants are prebiotics. The highest effective treatment for NAFLD is, so far, weight loss achieved by caloric restriction. DF supplementation with oligofructose facilitates weight loss, enhances the production of beneficial metabolites, decreases some pathogenic bacteria population by increasing Bifidobacteria, and has effects on intestinal barrier permeability. DF use has been associated with improvement in diverse metabolic diseases, including NAFLD, by modifying gut microbiota. Additionally, it has been shown that a higher insoluble fiber consumption (7.5 g/day) revealed improvements in 3 different scores of liver fibrosis. Further research is needed, but given the evidence available, it is reasonable to prescribe its consumption in early stages of NAFLD in order to prevent disease progression. 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