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02194476e065595ba87d48ea1d29c3b557157f68ffd573682a6465acdb0b97bf  pmc_33105758.pdf

Title:          Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
Subject:        Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies.-6pt
Keywords:       antioxidants; fatty-acids; intrauterine-growth-restriction; pregnancy; swine-model
Author:         Ana Heras-Molina, José Luis Pesantez-Pacheco, Susana Astiz, Consolación Garcia-Contreras, Marta Vazquez-Gomez, Teresa Encinas, Cristina Óvilo, Beatriz Isabel and Antonio Gonzalez-Bulnes
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      Title: Materials and Methods 
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        Title: Animals and Experimental Design 
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        Title: Evaluation of the Oxidant/Antioxidant Status of the Offspring 
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       Item: 
        Title: Effects of Maternal Supplementation on Postnatal Patterns of Growth and Development of Offspring 
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        Title: Effects of Maternal Supplementation on the Metabolic Status of Offspring 
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       Item: 
        Title: Effects of Maternal Supplementation on Fatty Acid Composition of the Offspring 
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     Item: 
      Title: Discussion 
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      Title: References
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   Info: 
    Title: Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
    Author: Ana Heras-Molina, José Luis Pesantez-Pacheco, Susana Astiz, Consolación Garcia-Contreras, Marta Vazquez-Gomez, Teresa Encinas, Cristina Óvilo, Beatriz Isabel and Antonio Gonzalez-Bulnes
    Subject: Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies.-6pt
    Keywords: antioxidants; fatty-acids; intrauterine-growth-restriction; pregnancy; swine-model
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   Type: CRC32
  Checksum: 2e548e4829dfd9a0a367ac1bad124a0c
   Type: MD5
  Checksum: 68939f3281c0022569194c38f01eb0794d73ab82
   Type: SHA-1