dc2a73da1b8a2f68d03213817a6d101d pmc_33110094.pdf 79ccfe135ac69221eafb27721d5c8c2a217b2606 pmc_33110094.pdf e3368cea66b57c7d1c0e9070183b5dc5b50ac64ae0fdfb6ec6d576b9f8222c9e pmc_33110094.pdf Title: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-74947-4 Author: Marta Cáceres Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 20 17:55:03 2020 CEST ModDate: Wed Oct 21 10:59:49 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2883700 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XVVMYY+Wingdings-Regular Type 1C WinAnsi yes yes yes 312 0 MinionPro-Regular Type 1C Custom yes no yes 31 0 HCPWMZ+Corbel-Bold CID TrueType Identity-H yes yes yes 34 0 Corbel2 TrueType WinAnsi yes no yes 35 0 MZEFEP+Corbel CID TrueType Identity-H yes yes yes 36 0 MinionPro-Bold Type 1C Custom yes no yes 32 0 MinionPro-It Type 1C Custom yes no yes 33 0 AGUYSN+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 200 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-09-29 02:40:03 CEST RepresentationInformation: pmc_33110094.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-09 03:36:58 CET Size: 2883700 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 384 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice Children: Item: Title: Materials and methods Children: Item: Title: Study design. Item: Title: Surgical technique. Item: Title: Postoperative care and necropsy. Item: Title: Histological study. Item: Title: Gene expression assays. Item: Title: Microarray data processing and gene expression analysis. Item: Title: Human samples. Item: Title: Statistical analysis. Item: Title: Results Children: Item: Title: Model validation. Item: Title: The number of PanIN 1 lesions in the ligated pancreas is reduced. Item: Title: The number of HGPL in the ligated pancreas is reduced. Item: Title: The risk of developing HGPL is reduced in the ligated pancreas. Item: Title: Transcriptional analysis reveals downregulation of the acinar program in distal pancreas. Item: Title: Human experience in the ligated pancreas. Item: Title: Discussion Item: Title: References Item: Title: Acknowledgements Info: Title: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice Author: Marta Cáceres Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-74947-4 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 20 18:25:03 CEST 2020 ModDate: Wed Oct 21 10:59:49 CEST 2020 ID: 0x02407de3d1b4138cb7db118877e611f5, 0xcd4121dd4828e8f0b11964bfe2a8e9f8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 1114 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1659 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 1947 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 654 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1448 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1458 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1182 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: HCPWMZ+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: MZEFEP+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XVVMYY+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XVVMYY+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AGUYSN+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: AGUYSN+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: MZEFEP+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MZEFEP+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: HCPWMZ+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HCPWMZ+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2020-10-20T21:25:03+05:30 Springer 2020-10-21T10:59:49+02:00 2020-10-21T10:59:49+02:00 application/pdf https://doi.org/10.1038/s41598-020-74947-4 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-020-74947-4 Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice Marta Cáceres Rita Quesada Mar Iglesias Francisco X. 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